Evidence-based neuroimaging in acute ischemic stroke

Neuroimaging Clinics of North America

Volumn 13, Issue 2, 2003, Pages 167-183

  Vo, Katie D ^a   Lin, Weili ^b   Lee, Jin Moo ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

BRAIN ANGIOGRAPHY; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; BRAIN RADIOGRAPHY; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CORRELATION ANALYSIS; COST BENEFIT ANALYSIS; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; EVIDENCE BASED MEDICINE; FUNCTIONAL ANATOMY; HUMAN; INTERMETHOD COMPARISON; MAGNETIC RESONANCE ANGIOGRAPHY; MEDICAL DECISION MAKING; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOMES RESEARCH; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT PLANNING;

EID: 0038729395     PISSN: 10525149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1052-5149(03)00027-3     Document Type: Review

References (143)

1. American Heart Association. 2002 Heart and stroke statistical update. Dallas (TX): AHA; 2001.
2. Sacco RL, Boden-Albala B, Gan R, Chen X, et al. Stroke incidence among white, black, and Hispanic residents of an urban community: the Northern Manhattan Stroke Study. Am J Epidemiol 1998;147: 259-68.
3. Taylor TN, Davis PH, Tomer JC, et al. Lifetime cost of stroke in the United States. Stroke 1996;27: 1459-66.
4. Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke Registry: analysis of 1000 consecutive patients with first stroke. Stroke 1988;19:1083-92.
5. NINDS. Tissue plasminogen activator for acute ischemic stroke: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581-7.
6. Kwiatkowski TG, Libman RB, Frankel M, et al. Effects of tissue plasminogen activator for acute ischemic stroke at one year. National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group. N Engl J Med 1999;340:1781-7.
7. Fagan SC, Morgenstern LB, Petitta A, et al. Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke: N1NDS rt-PA Stroke Study Group. Neurology 1998;50:883-90.
8. Hacke W, Kaste M, Fieschi C, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274:1017-25.
9. Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 1998;352:1245-51.
10. Clark WM, Wissman S, Albers GW, et al. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999;282:2019-26.
11. Marler JR, Tilley BC, Lu M, et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. Neurology 2000;55:1649-55.
12. Guyatt GH, Haynes RB, Jaeschke RZ, et al. Users' Guides to the Medical Literature. XXV. Evidencebased medicine: principles for applying the Users' Guides to patient care. Evidence-Based Medicine Working Group. JAMA 2000;284:1290-6.
13. Field AG, Wang E. Evaluation of the patient with nontraumatic headache: an evidence based approach. Emerg Med Clin North Am 1999;17:127-52.
14. New PF, Aronow S. Attenuation measurements of whole blood and blood fractions in computed tomography. Radiology 1976;121:635-40.
15. Smith Jr WP, Bamitzky S, Rengachary SS. Acute isodense subdural hematomas: a problem in anemic patients. AJR Am J Roentgenol 1981;136:543-6.
16. Culebras A, Kase CS, Masdeu JC, et al. Practice guidelines for the use of imaging in transient ischemic attacks and acute stroke: a report of the Stroke Council, American Heart Association. Stroke 1997;28: 1480-97.
17. Beauchamp Jr NJ, Barker PB, Wang PY, et al. Imaging of acute cerebral ischemia. Radiology 1999;212: 307-24.
18. Paxton R, Ambrose J. The EMI scanner. A brief review of the first 650 patients. Br J Radiol 1974;47: 530-65.
19. Jacobs L, Kinkel WR, Heffner Jr RR. Autopsy correlations of computerized tomography: experience with 6000 CT scans. Neurology 1976;26:1111-8.
20. Adams Jr HP, Kassell NF, Tomer JC, et al. CT and clinical correlations in recent aneurysmal subarachnoid hemorrhage: a preliminary report of the Cooperative Aneurysm Study. Neurology 1983;33:981-8.
21. van der Wee N, Rinkel GJ, Hasan D, et al. Detection of subarachnoid haemorrhage on early CT: is lumbar puncture still needed after a negative scan? J Neurol Neurosurg Psychiatry 1995;58:357-9.
22. Sames TA, Storrow AB, Finkelstein JA, et al. Sensitivity of new-generation computed tomography in subarachnoid hemorrhage. Acad Emerg Med 1996; 3:16-20.
23. Sidman R, Connolly E, Lemke T. Subarachnoid hemorrhage diagnosis: lumbar puncture is still needed when the computed tomography scan is normal. Acad Emerg Med 1996;3:827-31.
24. Bradley Jr WG. MR appearance of hemorrhage in the brain. Radiology 1993;189:15-26.
25. Gomori JM, Grossman RI, Goldberg HI, et al. Intracranial hematomas: imaging by high-field MR. Radiology 1985;157:87-93.
26. Edelman RR, Johnson K, Buxton R, et al. MR of hemorrhage: a new approach. AJNR Am J Neuroradiol 1986;7:751-6.
27. Thulbom K, Atlas S. Intracranial hemorrhage. New York (NY): Raven Press; 1991.
28. Schellinger PD, Jansen O, Fiebach JB, et al. A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage. Stroke 1999;30: 765-8.
29. Patel MR, Edelman RR, Warach S. Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging. Stroke 1996;27: 2321-4.
30. Linfante I, Llinas RH, Caplan LR, et al. MRI features of intracerebral hemorrhage within 2 hours from symptom onset. Stroke 1999;30:2263-7.
31. Bradley Jr WG, Schmidt PG. Effect of methemoglobin formation on the MR appearance of subarachnoid hemorrhage. Radiology 1985;156:99-103.
32. Noguchi K, Ogawa T, Seto H, et al. Subacute and chronic subarachnoid hemorrhage: diagnosis with fluid-attenuated inversion-recovery MR imaging. Radiology 1997;203:257-62.
33. Noguchi K, Ogawa T, Inugami A, et al. Acute subarachnoid hemorrhage: MR imaging with fluidattenuated inversion recovery pulse sequences. Radiology 1995;196:773-7.
34. Bakshi R, Kamran S, Kinkel PR, et al. Fluid-attenuated inversion-recovery MR imaging in acute and subacute cerebral intraventricular hemorrhage. AJNR Am J Neuroradiol 1999;20:629-36.
35. Bakshi R, Caruthers SD, Janardhan V, et al. Intraventricular CSF pulsation artifact on fast fluid-attenuated inversion-recovery MR images: analysis of 100 consecutive normal studies. AJNR Am J Neuroradiol 2000;21:503-8.
36. Dechambre SD, Duprez T, Grandin CB, et al. High signal in cerebrospinal fluid mimicking subarachnoid haemorrhage on FLAIR following acute stroke and intravenous contrast medium. Neuroradiology 2000;42:608-11.
37. Melhem ER, Jara H, Eustace S. Fluid-attenuated inversion recovery MR imaging: identification of protein concentration thresholds for CSF hyperintensity. AJR Am J Roentgenol 1997;169:859-62.
38. Ogawa T, Inugami A, Fujita H, et al. MR diagnosis of subacute and chronic subarachnoid hemorrhage: comparison with CT. AJR Am J Roentgenol 1995;165:1257-62.
39. Hesselink JR, Healy ME, Dunn WM, et al. Magnetic resonance imaging of hemorrhagic cerebral infarction. Acta Radiol Suppl 1986;369:46-8.
40. Kidwell CS, Saver JL, Villablanca JP, et al. Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002;33:95-8.
41. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003-11.
42. Libman RB, Wirkowski E, Alvir J, et al. Conditions that mimic stroke in the emergency department: implications for acute stroke trials. Arch Neurol 1995;52:1119-22.
43. Norris JW, Hachinski VC. Misdiagnosis of stroke. Lancet 1982;1:328-31.
44. Kothari RU, Brott T, Broderick JP, et al. Emergency physicians: accuracy in the diagnosis of stroke. Stroke 1995;26:2238-41.
45. Truwit CL, Barkovich AJ, Gean-Marton A, et al. Loss of the insular ribbon: another early CT sign of acute middle cerebral artery infarction. Radiology 1990;176:801-6.
46. Tomura N, Uemura K, Inugami A, et al. Early CT finding in cerebral infarction: obscuration of the lentiform nucleus. Radiology 1988;168:463-7.
47. Patel SC, Levine SR, Tilley BC, et al. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA 2001;286:2830-8.
48. von Kummer R, Meyding-Lamade U, Forsting M, et al. Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol 1994;15:9-15; discussion, 16-8.
49. Schriger DL, Kalafut M, Starkman S, et al. Cranial computed tomography interpretation in acute stroke: physician accuracy in determining eligibility for thrombolytic therapy. JAMA 1998;279:1293-7.
50. Grotta JC, Chiu D, Lu M, et al. Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. Stroke 1999;30:1528-33.
51. Toni D, Fiorelli M, Bastianello S, et al. Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on clinical outcome. Neurology 1996;46:341-5.
52. Larrue V, von Kummer R, del Zoppo G, et al. Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997;28:957-60.
53. Larrue V, von Kummer RR, Muller A, et al. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 2001;32:438-41.
54. von Kummer R, Allen KL, Holle R, et al. Acute stroke: usefulness of early CT findings before thrombolytic therapy. Radiology 1997;205:327-33.
55. Kucharczyk J, Mintorovitch J, Asgari HS, et al. Diffusion/perfusion MR imaging of acute cerebral ischemia. Magn Reson Med 1991;19:311-5.
56. Reith W, Hasegawa Y, Latour LL, et al. Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model. Neurology 1995;45:172-7.
57. Mintorovitch J, Moseley ME, Chileuitt L, et al. Comparison of diffusion- and T2-weighted MRI for the early detection of cerebral ischemia and reperfusion in rats. Magn Reson Med 1991;18:39-50.
58. Warach S, Gaa J, Siewert B, et al. Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 1995;37:231-41.
59. Moseley ME, Cohen Y, Mintorovitch J, et al. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med 1990;14:330-46.
60. Hoehn-Berlage M, Norris DG, Kohno K, et al. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 1995;15:1002-11.
61. Warach S, Boska M, Welch KM. Pitfalls and potential of clinical diffusion-weighted MR imaging in acute stroke. Stroke 1997;28:481-2.
62. Gonzalez RG, Schaefer PW, Buonanno FS, et al. Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 1999;210:155-62.
63. Lovblad KO, Laubach HJ, Baird AE, et al. Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol 1998;19:1061-6.
64. Fiebach JB, Schellinger PD, Jasen O, et al. CT and diffusion-weighted MR imaging in randomized order: diffusion-weighted imaging results in higher accuracy and lower interrator variability in the diagnosis of hyperacute ischemic stroke. Stroke 2002;33:2206-10.
65. Kidwell CS, Alger JR, Di Salle F, et al. Diffusion MRI in patients with transient ischemic attacks. Stroke 1999;30:1174-80.
66. Marks MP, de Crespigny A, Lentz D, et al. Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging. Radiology 1996;199:403-8.
67. Ay H, Buonanno FS, Rordorf G, et al. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999;52:1784-92.
68. Ebisu T, Tanaka C, Umeda M, et al. Discrimination of brain abscess from necrotic or cystic tumors by diffusion-weighted echo planar imaging. Magn Reson Imaging 1996;14:1113-6.
69. Ohta K, Funaki M, Tanaka M, et al. Early cerebellar involvement on diffusion-weighted magnetic resonance images in herpes simplex encephalitis. J Neurol 1999;246:736-8.
70. Sener RN. Herpes simplex encephalitis: diffusion MR imaging findings. Comput Med Imaging Graph 2001;25:391-7.
71. Bahn MM, Kido DK, Lin W, et al. Brain magnetic resonance diffusion abnormalities in Creutzfeldt-Jakob disease. Arch Neurol 1997;54:1411-5.
72. Gauvain KM, McKinstry RC, Mukherjee P, et al. Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol 2001;177:449-54.
73. Chen S, Ikawa F, Kurisu K, et al. Quantitative MR evaluation of intracranial epidermoid tumors by fast fluid-attenuated inversion recovery imaging and echo-planar diffusion-weighted imaging. AJNR Am J Neuroradiol 2001;22:1089-96.
74. Chu K, Kang DW, Kim JY, et al. Diffusion-weighted magnetic resonance imaging in nonconvulsive status epilepticus. Arch Neurol 2001;58:993-8.
75. Hasegawa Y, Formato JE, Latour LL, et al. Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water. Stroke 1996;27:1648-55; discussion, 1655-6.
76. Schwamm LH, Koroshetz WJ, Sorensen AG, et al. Time course of lesion development in patients with acute stroke: serial diffusion- and hemodynamic-weighted magnetic resonance imaging. Stroke 1998;29:2268-76.
77. Barber PA, Darby DG, Desmond PM, et al. Prediction of stroke outcome with echoplanar perfusionand diffusion-weighted MRI. Neurology 1998;51:418-26.
78. Lovblad KO, Baird AE, Schlaug G, et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997;42:164-70.
79. Tong DC, Yenari MA, Albers GW, et al. Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke. Neurology 1998;50:864-70.
80. van Everdingen KJ, van der Grond J, Kappelle LJ, et al. Diffusion-weighted magnetic resonance imaging in acute stroke. Stroke 1998;29:1783-90.
81. Villringer A, Rosen BR, Belliveau JW, et al. Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 1988;6:164-74.
82. Rosen BR, Belliveau JW, Buchbinder BR, et al. Contrast agents and cerebral hemodynamics. Magn Reson Med 1991;19:285-92.
83. Ostergaard L, Sorensen AG, Kwong KK, et al. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. Magn Reson Med 1996;36:726-36.
84. Ostergaard L, Weisskoff RM, Chesler DA, et al. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis. Magn Reson Med 1996;36:715-25.
85. Rosen BR, Belliveau JW, Vevea JM, et al. Perfusion imaging with NMR contrast agents. Magn Reson Med 1990;14:249-65.
86. Lin W, Celik A, Derdeyn C, et al. Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study. J Magn Reson Imaging 2001;14:659-67.
87. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 1981;12: 723-5.
88. Baird AE, Benfield A, Schlaug G, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 1997;41:581-9.
89. Beaulieu C, de Crespigny A, Tong DC, et al. Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann Neurol 1999;46:568-78.
90. Perkins CJ, Kahya E, Roque CT, et al. Fluid-attenuated inversion recovery and diffusion- and perfusion-weighted MRI abnormalities in 117 consecutive patients with stroke symptoms. Stroke 2001;32:2774-81.
91. Warach S, Pettigrew LC, Dashe JF, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging: Citicoline 010 Investigators. Ann Neurol 2000;48:713-22.
92. Clark WM, Wechsler LR, Sabounjian LA, et al. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 2001;57:1595-602.
93. Uno M, Harada M, Yoneda K, et al. Can diffusion and perfusion-weighted magnetic resonance imaging evaluate the efficacy of acute thrombolysis in patients with internal carotid artery or middle cerebral artery occlusion? Neurosurgery 2002;50:28-34; discussion, 34-5.
94. Minematsu K, Li L, Sotak CH, et al. Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats. Stroke 1992; 23:1304-10; discussion, 1310-1.
95. Hasegawa Y, Fisher M, Latour LL, et al. MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia. Neurology 1994;44: 1484-90.
96. Kidwell CS, Saver JL, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000;47:462-9.
97. Fiehler J, Foth M, Kucinski T, et al. Severe ADC decreases do not predict irreversible tissue damage in humans. Stroke 2002;33:79-86.
98. Grohn OH, Kauppinen RA. Assessment of brain tissue viability in acute ischemic stroke by BOLD MRI. NMR Biomed 2001;14:432-40.
99. 2 obtained with MRI in determining ischemic brain tissue at risk [abstract 252]. Presented at the 26th International Stroke Conference. 2001.
100. Powers WJ, Grubb RL, Darriet D, et al. Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 1985;5:600-8.
101. Touzani O, Young AR, Derlon JM, et al. Progressive impairment of brain oxidative metabolism reversed by reperfusion following middle cerebral artery occlusion in anaesthetized baboons. Brain Res 1997;767:17-25.
102. Gur D, Good WF, Wolfson Jr SK, et al. In vivo mapping of local cerebral blood flow by xenon-enhanced computed tomography. Science 1982;215:1267-8.
103. Wolfson Jr SK, Clark J, Greenberg JH, et al. Xenonenhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons. Stroke 1990;21:751-7.
104. DeWitt DS, Fatouros PP, Wist AO, et al. Stable xenon versus radiolabeled microsphere cerebral blood flow measurements in baboons. Stroke 1989;20:1716-23.
105. Firlik AD, Kaufmann AM, Wechsler LR, et al. Quantitative cerebral blood flow determinations in acute ischemic stroke: relationship to computed tomography and angiography. Stroke 1997;28:2208-13.
106. Firlik AD, Yonas H, Kaufmann AM, et al. Relationship between cerebral blood flow and the development of swelling and life-threatening hemiation in acute ischemic stroke. J Neurosurg 1998;89:243-9.
107. Pindzola RR, Balzer JR, Nemoto EM, et al. Cerebrovascular reserve in patients with carotid occlusive disease assessed by stable xenon-enhanced CT cerebral blood flow and transcranial Doppler. Stroke 2001;32: 1811-7.
108. Webster MW, Makaroun MS, Steed DL, et al. Compromised cerebral blood flow reactivity is a predictor of stroke in patients with symptomatic carotid artery occlusive disease. J Vasc Surg 1995;21:338-44; discussion, 344-5.
109. Plougmann J, Astrup J, Pedersen J, et al. Effect of stable xenon inhalation on intracranial pressure during measurement of cerebral blood flow in head injury. J Neurosurg 1994;81:822-8.
110. Lev MH, Segal AZ, Farkas J, et al. Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome. Stroke 2001;32:2021-8.
111. Mayer TE, Hamann GF, Baranczyk J, et al. Dynamic CT perfusion imaging of acute stroke. AJNR Am J Neuroradiol 2000;21:1441-9.
112. Baron JC, Frackowiak RS, Herholz K, et al. Use of PET methods for measurement of cerebral energy metabolism and hemodynamics in cerebrovascular disease. J Cereb Blood Flow Metab 1989;9:723-42.
113. Baron JC, Bousser MG, Rey A, et al. Reversal of focal "misery-perfusion syndrome" by extra-intracranial arterial bypass in hemodynamic cerebral ischemia: a case study with 150 positron emission tomography. Stroke 1981;12:454-9.
114. Furlan M, Marchal G, Viader F, et al. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 1996;40:216-26.
115. Heiss WD, Huber M, Fink GR, et al. Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 1992;12:193-203.
116. Wise RJ, Bemardi S, Frackowiak RS, et al. Serial observations on the pathophysiology of acute stroke: the transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain 1983;106(Pt 1): 197-222.
117. Grubb Jr RL, Derdeyn CP, Fritsch SM, et al. Importance of hemodynamic factors in the prognosis of symptomatic carotid occlusion. JAMA 1998;280:1055-60.
118. Heiss WD, Grond M, Thiel A, et al. Tissue at risk of infarction rescued by early reperfusion: a positron emission tomography study in systemic recombinant tissue plasminogen activator thrombolysis of acute stroke. J Cereb Blood Flow Metab 1998;18:1298-307.
119. Brass LM, Walovitch RC, Joseph JL, et al. The role of single photon emission computed tomography brain imaging with 99mTc-bicisate in the localization and definition of mechanism of ischemic stroke. J Cereb Blood Flow Metab 1994;14(Suppl 1):S91-8.
120. Giubilei F, Lenzi GL, Di Piero V, et al. Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke. Stroke 1990; 21:895-900.
121. Sasaki O, Takeuchi S, Koizumi T, et al. Complete recanalization via fibrinolytic therapy can reduce the number of ischemic territories that progress to infarction. AJNR Am J Neuroradiol 1996;17:1661-8.
122. Caplan LR, Mohr JP, Kistler JP, et al. Should thrombolytic therapy be the first-line treatment for acute ischemic stroke? Thrombolysis - not a panacea for ischemic stroke. N Engl J Med 1997;337:1309-10; discussion, 1313.
123. del Zoppo GJ, Poeck K, Pessin MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 1992;32:78-86.
124. Lewandowski CA, Frankel M, Tomsick TA, et al. Combined intravenous and intra-arterial R-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 1999;30:2598-605.
125. von Kummer R, Hacke W. Safety and efficacy of intravenous tissue plasminogen activator and heparin in acute middle cerebral artery stroke. Stroke 1992;23:646-52.
126. Fieschi C, Argentino C, Lenzi GL, et al. Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours. J Neurol Sci 1989;91:311-21.
127. Ringelstein EB, Biniek R, Weiller C, et al. Type and extent of hemispheric brain infarctions and clinical outcome in early and delayed middle cerebral artery recanalization. Neurology 1992;42:289-98.
128. Bozzao L, Fantozzi LM, Bastianello S, et al. Early collateral blood supply and late parenchymal brain damage in patients with middle cerebral artery occlusion. Stroke 1989;20:735-40.
129. ACAS. Endarterectomy for asymptomatic carotid artery stenosis: Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273:1421-8.
130. Knauth M, von Kummer R, Jansen O, et al. Potential of CT angiography in acute ischemic stroke. AJNR Am J Neuroradiol 1997;18:1001-10.
131. Wildermuth S, Knauth M, Brandt T, et al. Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke. Stroke 1998; 29:935-8.
132. Shrier DA, Tanaka H, Numaguchi Y, et al. CT angiography in the evaluation of acute stroke. AJNR Am J Neuroradiol 1997;18:1011-20.
133. Katz DA, Marks MP, Napel SA, et al. Circle of Willis: evaluation with spiral CT angiography, MR angiography, and conventional angiography. Radiology 1995;195:445-9.
134. Verro P, Tanenbaum LN, Borden NM, et al. CT angiography in acute ischemic stroke: preliminary results. Stroke 2002;33:276-8.
135. Stock KW, Radue EW, Jacob AL, et al. Intracranial arteries: prospective blinded comparative study of MR angiography and DSA in 50 patients. Radiology 1995;195:451-6.
136. Korogi Y, Takahashi M, Mabuchi N, et al. Intracranial vascular stenosis and occlusion: diagnostic accuracy of three-dimensional, Fourier transform, time-of-flight MR angiography. Radiology 1994;193:187-93.
137. Husson B, Rodesch G, Lasjaunias P, et al. Magnetic resonance angiography in childhood arterial brain infarcts: a comparative study with contrast angiography. Stroke 2002;33:1280-5.
138. Liberopoulos K, Kaponis A, Kokkinis K, et al. Comparative study of magnetic resonance angiography, digital subtraction angiography, duplex ultrasound examination with surgical and histological findings of atherosclerotic carotid bifurcation disease. Int Angiol 1996;15:131-7.
139. Cloft HJ, Murphy KJ, Prince MR, et al. 3D gadolinium-enhanced MR angiography of the carotid arteries. Magn Reson Imaging 1996;14:593-600.
140. Willig DS, Turski PA, Frayne R, et al. Contrast-enhanced 3D MR DSA of the carotid artery bifurcation: preliminary study of comparison with unenhanced 2D and 3D time-of-flight MR angiography. Radiology 1998;208:447-51.
141. Okumura A, Araki Y, Nishimura Y, et al. The clinical utility of contrast-enhanced 3D MR angiography for cerebrovascular disease. Neurol Res 2001;23:767-71.
142. Alberts MJ, Hademenos G, Latchaw RE, et al. Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. JAMA 2000;283: 3102-9.
143. Baird AE, Warach S. Magnetic resonance imaging of acute stroke. J Cereb Blood Flow Metab 1998;18: 583-609.