Progressive impairment of brain oxidative metabolism reversed by reperfusion following middle cerebral artery occlusion in anaesthetized baboons

Brain Research

Volumn 767, Issue 1, 1997, Pages 17-25

  Touzani, Omar ^a   Young, Alan R ^a,b   Derlon, Jean Michel ^a,c   Baron, Jean Claude ^a,b   MacKenzie, Eric T ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b INSERM   (France)

^c CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

Baboon; Cerebral ischemia; Infarction; Neuroprotection; Oxidative metabolism; Positron emission tomography; Reperfusion; Stroke

Indexed keywords

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BABOON; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN NECROSIS; BRAIN PERFUSION; BRAIN PROTECTION; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STROKE;

ANALYSIS OF VARIANCE; ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BRAIN; CEREBRAL ARTERIAL DISEASES; DISEASE PROGRESSION; LINEAR MODELS; MALE; OXIDATION-REDUCTION; PAPIO; REPERFUSION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030826280     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00515-5     Document Type: Article

References (36)

1. Astrup J. Energy-requiring cell functions in the ischemic brain. J. Neurosurg. 56:1982;482-487.
2. DeGirolami U., Crowell R.M., Marcoux F.W. Selective necrosis and total necrosis in focal cerebral ischemia. Neuropathologic observations on experimental middle cerebral artery occlusion in the Macaque monkey. J. Neuropathol. Exp. Neurol. 43:1984;57-71.
3. 15O and positron emission tomography: theory, procedure and normal values. J. Comput. Assist. Tomogr. 4:1980;727-736.
4. Hallenbeck J.M., Dutka A.J. Background review and current concepts of reperfusion injury. Arch. Neurol. 47:1990;1245-1254.
5. Hudgins W.R., Garcia J.H. Transorbital approach to the middle cerebral artery of the squirrel monkey: a technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke. 1:1970;107-111.
6. Jobert A., Young A.R, Petit-Taboue M.C., Travere J., Payen D., MacKenzie E.T., Baron J.C. Effects of etomidate on regional cerebral blood flow, blood volume, oxygen consumption and oxygen extraction fraction in the baboon by means of positron emission tomography. Circ. Metab. Cerv. 12:1995;217-231.
7. Jones T.H., Morawetz R.B., Crowell R.M., Marcoux F.W., FitzGibbon S.J., DeGirolami U., Ojemann R.G. Thresholds of focal cerebral ischemia in awake monkeys. J. Neurosurg. 54:1981;773-782.
8. Kozuka M., Kobayashi K., Iwata N. Changes in glucose utilization in the rat brain after transient forebrain ischemia. Stroke. 24:1993;1568-1575.
9. Li Y., Choop M., Garcia J.H., Yoshida Y., Zhang Z.G., Levine S.R. Distribution of the 72-kd heat shock protein as a function of transient focal cerebral ischemia in rats. Stroke. 23:1992;1292-1298.
10. Marchal G., Beaudouin V., Rioux P., de la Sayette V., Le Dose F., Derlon J.M., Baron J.C. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke. 27:1996;599-606.
11. Marchal G., Beaudouin V., Serrati C., Rioux P., Viader F., Baron J.C. New automated analysis of metabolic PET images: application to acute ischemic stroke. Cerbrovasc. Dis. 2:1992;235.
12. Marchal G., Serrati C., Rioux P., Petit-Taboué M.C., Viader F., de la Sayette V., Le Doze F., Lochon P., Derlon J.M., Orgogozo J.M., Baron J.C. PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome. Lancet. 341:1993;2-4.
13. Mazoyer B., Trebossen R., Schoukroun C., Verry B., Syrota A., Vacher J., Lemasson P., Monnet O., Bouvier A., Lecomte J.L. Physical characteristics of TTV03, a new high spatial resolution time-of-flight positron tomograph. I.E.E.E. Trans. Nucl. Sci. 37:1990;778-782.
14. Memezawa H., Minamisawa H., Smith M.L., Siesjö B.K. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in rats. Exp. Brain Res. 89:1992;67-78.
15. Memezawa H., Smith M.L., Siesjö B.K. Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke. 23:1992;552-559.
16. Müller T.B., Haraldseth O., Unsgard G. Characterization of the microcirculation during ischemia and reperfusion in the penumbra of a rat model of temporary middle cerebral artery occlusion: a laser Doppler flowmetry study. Int. J. Microcirc. 14:1994;289-295.
17. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group Tissue plasminogen activator for acute ischemic stroke. New Engl. J. Med. 24:1995;1582-1587.
18. Nishigaya K., Yoshida Y., Sasuga M., Nukui H., Ooneda G. Effect of recirculation on exacerbation of ischemic vascular lesions in rat brain. Stroke. 22:1991;635-642.
19. Nowicki J.P., Assumel-Lurdin C., Duverger D., MacKenzie E.T. Temporal evolution of regional energy metabolism following focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 8:1988;462-473.
20. Overgaard K., Sereghy T., Pedersen H., Boysen G. Effect of delayed thrombolysis with rt-PA in a rat embolic stroke model. J. Cereb. Blood Flow Metab. 14:1994;472-477.
21. Overgaard K., Sperling B., Boysen G., Pedersen H., Gam J., Ellemann K., Karle A., Arlien-Soborg P., Olsen T.S., Videbaek C., Knudsen J.B. Thrombolytic therapy in acute ischemic stroke. A Danish pilot study. Stroke. 24:1993;1439-1446.
22. 15O. Eur. J. Nucl. Med. 10:1985;387-391.
23. Phillis J.W., O'Regan M.H., Estevez A.Y., Song A.Y., Vanderheide S.J. Cerebral energy metabolism during severe ischemia of varying duration and following reperfusion. J. Neurochem. 67:1996;1525-1531.
24. 2 changes in stroke: the associated metabolic and perfusion characteristics. J. Cereb. Blood Flow Metab. 7(Suppl. 1):1987;S55.
25. Preziosi P., Vacca M. Adrenocortical suppression and other endocrine effects of etomidate. Life Sci. 42:1988;477-489.
26. Riche D., Hantraye P., Guibert B., Naquet R., Loc'h C., Mazière B., Mazière M. Anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography. Brain Res. Bull. 20:1988;283-301.
27. Selman W.R., Crumrine R.C., Ricci A.J., LaManna J.C., Ratcheson R.A., Lust W.D. Impairment of metabolic recovery with increasing periods of middle cerebral artery occlusion in rats. Stroke. 21:1990;467-471.
28. Sette G., Baron J.C., Mazoyer B., Levasseur M., Pappata S., Crouzel C. Local brain haemodynamics and oxygen metabolism in cerebrovascular disease: positron emission tomography. Brain. 112:1989;931-951.
29. Slivka A., Murphy E., Horrocks L. Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat. Stroke. 26:1995;1061-1066.
30. Touzani O., Young A.R., Derlon J.M., Beaudouin V., Marchal G., Rioux P., Mézenge F., Baron J.C., MacKenzie E.T. Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion: a positron emission tomographic investigation in anaesthetized baboons. Stroke. 26:1995;2112-2119.
31. Traupe H., Kruse E., Heiss W.D. Reperfusion of focal ischemia of varying duration: postischemic hyper- and hypoperfusion. Stroke. 13:1982;615-622.
32. Wardlaw J.M., Dennis M.S., Lindley R.I., Warlow C.P., Sandercock P.A.G., Sellar R. Does early reperfusion of a cerebral infarct influence cerebral swelling in the acute stage or the final clinical outcome? Cerebrovasc. Dis. 3:1993;86-93.
33. Weinstein P.R., Anderson G.G., Telles D.A. Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats. Stroke. 17:1986;318-324.
34. Yang G.Y., Betz A.L. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke. 25:1994;1658-1665.
35. Young A.R., Sette G., Touzani O., Rioux P., Derlon J.M., MacKenzie E.T., Baron J.C. Relationships between high oxygen extraction fraction in the acute stage and final infarction in reversible middle cerebral artery occlusion. An investigation in anaesthetized baboons with positron emission tomography. J. Cereb. Blood Flow Metab. 16:1996;1176-1188.
36. Young A.R., Touzani O., Sette G., Derlon J.M., MacKenzie E.T., Baron J.C. Early reperfusion in the anaesthetized baboon reduces brain damage following middle cerebral artery occlusion: a quantitative analysis of infarction volume. Stroke. 28:1997;632-638.