Maspin - A novel protease inhibitor with tumor-suppressing activity in breast cancer

Acta Oncologica

Volumn 39, Issue 8, 2000, Pages 931-934

  Maass, N ^a   Hojo, T ^a   Zhang, M ^a   Sager, R ^a   Jonat, W ^a   Nagasaki, K ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; COMPLEMENTARY DNA; CYTOSINE; MASPIN; PROTEIN P53; SERINE PROTEINASE INHIBITOR;

BREAST CANCER; BREAST EPITHELIUM; CANCER INHIBITION; CANCER THERAPY; CONFERENCE PAPER; DISEASE MARKER; DOWN REGULATION; GENE FUNCTION; GENETIC TRANSFECTION; HUMAN; HYBRIDIZATION; METASTASIS; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALS; BREAST NEOPLASMS; GENES, TUMOR SUPPRESSOR; HUMANS; PROTEIN BIOSYNTHESIS; PROTEINS; SERINE PROTEINASE INHIBITORS; SERPINS;

EID: 0034500705     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02841860050215909     Document Type: Conference Paper

References (40)

1. Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer
2. Structure and mechanism of action of serpins
3. The serpin superfamily of proteinase inhibitors: Structure, function and regulation
4. Membrane proteases: Role in tissue remodeling and tumor invasion
5. Immunohistochemical localizations of the plasminogen activator inhibitor-I in breast cancer
6. Clinical impact of the plasminogen activation system in tumor invasion and metastasis: Prognostic relevance and target for therapy
7. Both cytosols and detergent extract of breast cancer tissue are suited to evaluate the prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1
8. Production, purification, and characterization of recombinant maspin proteins
9. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
10. Positive selection of candidate tumor-suppressor genes by subtractive hybridisation
11. RNA genetics of breast cancer: Maspin as paradigm
12. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of human squamous cell carcinoma antigene
13. Report of the first international workshop on human chromosome 18 mapping
14. A somatic cell hybrid panel for regional mapping of human chromosome 18
15. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells
16. Maspin. A tumor suppressing serpin
17. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases
18. Seftor REB Biological function(s) of maspin
19. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface
20. Transactivation through Ets and Apl transcriptional sites determines the expression of the tumor-suppressing gene maspin
21. Transkriptionelle Regulierung von protease-inhibitor maspin in Brustepithel- u. Brusttumor-Zellen
22. Epigenetic silencing of maspin gene expression in human breast cancer
23. Function of maspin
24. mMaspin: The mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility
25. Gamma linolenic acid regulates expression of maspin and the motility of cancer cells
26. Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells
27. Maspin suppresses the invasive phenotype of human breast carcinoma
28. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin
29. Sensitive detection of circulating breast cancer cells by reverse-transcriptase polymerase chain reaction of maspin gene
30. Detection of circulating tumor cells by reverse transcriptase polymerase chain reaction of maspin in patients with breast cancer undergoing conventional-dose chemotherapy
31. p53 regulates the expression of tumor suppressor gene maspin
32. Maspin is an angiogenesis inhibitor
33. Angiogenesis as a predictor of clinical outcome in cancer patients
34. De-mystifying the mechanism(s) of maspin
35. Expression of tumor suppressor gene maspin in human breast cancer tissue
36. Characterizations of the extracellular matrix and proteinase inhibitor content of human myoepithelial tumors
37. The myoepithelial defence: A host defence against cancer
38. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
39. Expression genetics in cancer: Shifting the focus from DNA to RNA
40. Expression genetics: A different approach to cancer diagnosis and prognosis