Muscarinic receptors couple to modulation of nicotinic ACh receptor desensitization in myenteric neurons

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 1 48-1, 2003, Pages

  Brown, Erika N ^a   Galligan, James J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Electrophysiology; Enteric nervous system; Intracellular signaling

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE ACTIVATOR; FORSKOLIN; FORSKOLIN DERIVATIVE; GUANOSINE TRIPHOSPHATE; HEXAMETHONIUM; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; PHORBOL DIBUTYRATE; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; SCOPOLAMINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; GUINEA PIG; INTESTINE INNERVATION; MYENTERIC PLEXUS; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 0038678022     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00053.2003     Document Type: Article

References (27)

1. 2X channels in submucosal neurons. Am J Physiol Gastrointest Liver Physiol 283: G1238-G1248, 2002.
2. Bertrand PP and Galligan JJ. Signal transduction pathways causing slow synaptic excitation in myenteric AH neurons of guinea pig ileum. Am J Physiol Gastrointest Liver Physiol 269: G710-G720, 1995.
3. Cuevas J and Adams DJ. Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons. J Neurophysiol 84: 1961-1970, 2000.
4. Downing JE and Role LW. Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. Proc Natl Acad Sci USA 84: 7739-7743, 1997.
5. Fenster CP, Beckman ML, Parker JC, Sheffield EB, Whitworth TL, Quick MW, and Lester RA. Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C. Mol Pharmacol 55: 432-443, 1999.
6. Galligan JJ. Pharmacology of synaptic transmission in the enteric nervous system. Curr Opin Pharmacol 2: 623-629, 2002.
7. Galligan JJ, LePard KJ, Schneider DA, and Zhou X. Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system. J Auton Nerv Syst 81: 97-103, 2000.
8. Huganir RL, Delcour AH, Greengard P, and Hess GP. Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature 321: 774-776, 1986.
9. Khakh BS, Zhou X, Sydes J, Galligan JJ, and Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels. Nature 406: 405-410, 2000.
10. 2+ mobilization via protein kinase-C activation at the mouse neuromuscular junction. Br J Pharmacol 114: 461-467, 1995.
11. Liu DM, Cuevas J, and Adams DJ. VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. Eur J Neurosci 12: 2243-2251, 2000.
12. Lowes VL, Ip NY, and Wong YH. Integration of signals from receptor tyrosine kinases and G-protein-coupled receptors. Neurosignals 11: 5-19, 2002.
13. Lundberg JM. Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 48: 113-178, 1996.
14. McLarnon JG and Quastel DM. Thermodynamic parameters of end-plate channel blockade. J Neurosci 4: 939-944, 1984.
15. Nishizaki T and Sumikawa K. Direct action of 4-beta-phorbol-12,13-dibutyrate (PDBu) on nicotinic acetylcholine receptor channel independent of protein kinase C activation. Neurosci Lett 188: 129-131, 1995.
16. Nishizaki T and Sumikawa K. Effects of PKC and PKA phosphorylation on desensitization of nicotinic acetylcholine receptors. Brain Res 812: 242-245, 1998.
17. 2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system. J Physiol 368: 435-452, 1985.
18. North RA and Tokimasa T. Muscarinic synaptic potentials in guinea-pig myenteric plexus neurones. J Physiol 333: 151-156, 1982.
19. Peralta EG, Ashkenazi A, Winslow JW, Capon DJ, and Ramachandran J. Differential regulation of PI hydrolysis and adenlyl cyclase by muscarinic receptor subtypes. Nature 334: 434-437, 1988.
20. Quick MW and Lester RA. Desensitization of neuronal nicotinic receptors. J Neurobiol 53: 457-478, 2002.
21. Ron D and Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676, 1999.
22. Rossie S. Regulation of voltage-sensitive sodium and calcium channels by phosphorylation. Adv Second Messenger Phosphoprotein Res 33: 23-48, 1999.
23. Selbie LA and Hill SJ. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci 19: 87-93, 1998.
24. Soderling TR. The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem Sci 24: 232-236, 1999.
25. Wagoner PK and Pallotta BS. Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMP. Science 240: 1655-1657, 1988.
26. Zhou X and Galligan JJ. Non-additive interaction between nicotinic cholinergic and P2X purinergic receptors in guinea pig enteric neurons in culture. J Physiol 513: 685-697, 1998.
27. Zhou X, Ren J, Brown EN, Schneider D, Caraballo-Lopez Y, and Galligan JJ. Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons. J Pharmacol Exp Ther 302: 889-897, 2002.