VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation

European Journal of Neuroscience

Volumn 12, Issue 7, 2000, Pages 2243-2251

  Liu, Dong Mei ^a   Cuevas, Javier ^a,b   Adams, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Acetylcholine; Neuronal nicotinic receptor; Pituitary adenylate cyclase activating polypeptide; Vasoactive intestinal polypeptide

Indexed keywords

ACETYLCHOLINE; ANTIBODY; CHOLINERGIC RECEPTOR STIMULATING AGENT; GROWTH HORMONE RELEASING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NICOTINE; NICOTINIC RECEPTOR; PERTUSSIS TOXIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSIS; GANGLION; HEART NERVE; NONHUMAN; PARASYMPATHETIC NERVE CELL; PATCH CLAMP; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SUBMANDIBULAR GLAND; VOLTAGE CLAMP;

ACETYLCHOLINE; ANIMALS; ANTIBODIES; DRUG SYNERGISM; GANGLIA, PARASYMPATHETIC; GANGLIONIC STIMULANTS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEART; HETEROTRIMERIC GTP-BINDING PROTEINS; HORMONE ANTAGONISTS; MEMBRANE POTENTIALS; NEURONS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; NICOTINE; PATCH-CLAMP TECHNIQUES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RECEPTORS, NICOTINIC; SERMORELIN; SIGNAL TRANSDUCTION; SUBMANDIBULAR GLAND; VASOACTIVE INTESTINAL PEPTIDE; VASODILATOR AGENTS;

EID: 0033915951     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00116.x     Document Type: Article

References (41)

1. Adams, D.J., Cuevas, J. & Liu, D.-M. (1997) VIP potentiates nicotinic currents in parasymapthetic neurones from neonatal and adult rat intracardiac and submandibular ganglia. Proc. Aust. Neurosci. Soc., 8, 37.
2. Akasu, T., Gallagher, J.P., Hirai, K. & Shinnick-Gallagher, P. (1986) Vasoactive intestinal polypeptide depolarizations in cat bladder parasympathetic ganglia. J. Physiol. (Lond.), 374, 457-473.
3. Armour, J.A., Huang, M.H. & Smith, F.M. (1993) Peptidergic modulation of in situ canine intrinsic cardiac neurons. Peptides, 14, 191-202.
4. Basille, M., Gonzalez, B.J., Desrues, L., Demas, M., Fournier, A. & Vaudry, H. (1995) Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts. J. Neurochem., 65, 1318-1324.
5. Braas, K.M., May, V., Harakall, S.A., Hardwick, J.C. & Parsons, R.L. (1998) Pituitary adenylate cyclase-activating polypeptide expression and modulation of neuronal excitability in guinea pig cardiac ganglia. J. Neurosci., 18, 9766-9779.
6. 2+ currents by somatostatin in cultured ovine somatotrophs. J. Physiol. (Lond.), 491, 21-29.
7. Clapham, D.E. (1994) Direct G protein activation of ion channels? Annu. Rev. Neurosci., 17, 441-464.
8. Colquhoun, D. (1998) Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol, 125, 923-947.
9. Cuevas, J. & Adams, D.J. (1996) Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones. J. Physiol. (Lond.), 493, 503-515.
10. Della, N.G., Papka, R.E., Furness, J.B. & Costa, M. (1983) Vasoactive intestinal peptide-like immunoreactivity in nerves associated with the cardiovascular system of guinea pigs. Neuroscience, 9, 605-619.
11. Dubin, A.E., Rathouz, M.M., Mapp, K.S. & Berg, D.K. (1992) Cyclic AMP and the nicotinic response of bovine adrenal chromaffin cells. Brain Res., 586, 344-347.
12. Fieber, L.A. & Adams, D.J. (1991) Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia. J. Physiol. (Lond.), 434, 215-237.
13. Gourlet, P., Vandermeers, A., Vandermeers-Piret, M.C., Rathe, J., De Neef, P. & Robberecht, P. (1995) Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur. J. Pharmacol., 287, 7-11.
14. Gulbenkian, S., Edvinsson, L., Opgaard, O.S., Wharton, J., Polak, J.M. & David-Ferreira, J.F. (1990) Peptide containing nerve fibers in guinea-pig coronary arteries: immunohistochemistry, ultrastructure, and vasomotility. J. Auton. Nerv. Sys., 31, 153-168.
15. Gurantz, D., Harootunian, A.T., Tsien, R.Y., Dionne, V.E. & Margiotta, J.F. (1994) VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism. J. Neurosci., 14, 3540-3547.
16. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
17. Harmer, A.J., Arimura, A., Gozes, I., Journot, L., Laburthe, M., Pisegna, J.R., Rawlings, S.R., Robberecht, P., Said, S.I., Sreedharan, S.P., Wank, S.A. & Waschek, J.A. (1998) International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev., 50, 265-270.
18. Jeong, S.-W. & Wurster, R.D. (1997) Calcium channel currents in acutely dissociated intracardiac neurons from adult rats. J. Neurophysiol., 77, 1769-1778.
19. Jin, J.G., Katsoulis, S., Schmidt, W.E. & Grider, J.R. (1994) Inhibitory transmission in taenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors. J. Pharmacol. Exp. Therap., 270, 433-439.
20. Karasawa, Y., Furukawa, Y., Ren, L., Takei, M., Murakami, M., Narita, M. & Chiba, S. (1990) Cardiac responses to VIP and VIP-ergic-cholinergic interaction in isolated dog heart preparations. Eur. J. Pharmacol., 187, 9-17.
21. Kawatani, M., Rutigliano, M. & de Groat, W.C. (1985) Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide. Science, 229, 879-881.
22. Lichtman, J.W. (1977) The reorganization of synaptic connections in the rat submandibular ganglion during postnatal development. J. Physiol. (Lond.), 273, 155-175.
23. Liu, F., Wan, Q., Pristupa, Z.B., Yu, X.-M., Wang, Y.T. & Niznik, H.B. (2000) Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors. Nature, 403, 274-280.
24. Lundberg, J.M. (1981) Evidence for coexistence of vasoactive intestinal peptide (VIP) and acetylcholine in neurons of cat exocrine glands. Morphological, biochemical and functional aspects. Acta. Physiol. Scand., 112 (Suppl. 496), 1-57.
25. Margiotta, J.F. & Pardi, D. (1995) Pitutitary adenylate cyclase-activating polypeptide type 1 receptors mediate cyclic AMP-dependent enhancement of neuronal acetylcholine sensitivity. Mol. Pharmacol., 48, 63-71.
26. Mo, N. & Dun, N.J. (1984) Vasoactive intestinal polypeptide facilitates muscarinic transmission in mammalian sympathetic ganglia. Neurosci. Lett., 52, 19-23.
27. Mumby, S.M. & Gilman, A.G. (1991) Synthetic peptide antisera with determined specificity for G protein α or β subunits. Meth. Enzymol., 195, 215-233.
28. i1-2. J. Biol. Chem., 269, 15977-15980.
29. Pardi, D. & Margiotta, J.F. (1999) Pituitary adenylate cyclase-activating polypeptide activates a phospholipase C-dependent signal pathway in chick ciliary ganglion neurons that selectively inhibits α7-containing nicotinic receptors. J. Neurosci., 19, 6327-6337.
30. Poth, K., Nutter, T.J., Cuevas, J., Parker, M.J., Adams, D.J. & Luetje, C.W. (1997) Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. J. Neurosci., 17, 586-596.
31. Pusch, M. & Neher, E. (1988) Rates of diffusional exchange between small cells and a measuring patch pipette. Pflügers Arch., 411, 204-211.
32. Rawlings, S.R. & Hezareh, M. (1996) Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland. Endocrine Rev., 17, 4-29.
33. Rigel, D.F. (1988) Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT. Am. J. Physiol., 255, H311-H317.
34. Rubino, A., Hassall, C.J.S. & Burnstock, G. (1996) Autonomic control of the myocardium. Non-adrenergic non-cholinergic (N.A.N.C.) mechanisms. In Shepherd, J.T. & Vatner, S.F. (eds), Nervous Control of the Heart. Harwood Academic Publishers, The Netherlands, pp. 139-171.
35. Seabrook, G.R., Fieber, L.A. & Adams, D.J. (1990) Neurotransmission in neonatal rat cardiac ganglion in situ. Am. J. Physiol., 259, H997-H1005.
36. Seebeck, J., Schmidt, W.E., Kilbinger, H., Neumann, J., Zimmermann, N. & Herzig, S. (1996) PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 424-430.
37. Van Rampelbergh, J., Poloczek, P., Francoys, I., Delporte, C., Winand, J., Robberecht, P. & Waelbroeck, M. (1997) The pituitary adenylate cyclase activating polypeptide (PACAP I) and VIP (PACAP II VIP1) receptors stimulate inositol phosphate synthesis in transfected CHO cells through interaction with different G proteins. Biochim. Biophys. Acta., 1357, 249-255.
38. Vertongen, P., Velkeniers, B., Hooghe-Peters, E. & Robberecht, P. (1995) Differential alternative splicing of PACAP receptor in pituitary cell subpopulations. Molec. Cell. Endocrinol., 113, 131-135.
39. Weihe, F., Reinecke, M. & Forssmann, W.G. (1984) Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin-and substance P-like immunoreactive nerves. Cell Tissue Res., 236, 527-540.
40. Yonezawa, T., Furukawa, Y., Lajhe, M., Nagashima, Y., Hirose, M. & Chiba, S. (1996) PACAP-38 activates parasympathetic nerves in isolated, blood-perfused dog atria. Eur. J. Pharmacol., 315, 289-296.
41. 2+ channels sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. Neuron, 13, 657-669.