Sleep-wake mechanisms and drug discovery: Sleep EEG as a tool for the development of CNS-acting drugs

Dialogues in Clinical Neuroscience

Volumn 4, Issue 4, 2002, Pages 342-350

  Staner, Luc ^a  

^a FORENAP   (France)

Author keywords

Acetylcholine; Depression; EEG; Rapid eye movement sleep; Slow wave sleep

Indexed keywords

ACETYLCHOLINE; AMFEBUTAMONE; AMINEPTINE; ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINESTERASE INHIBITOR; DONEPEZIL; EPLIVANSERIN; HYPNOTIC AGENT; MUSCARINIC AGENT; NEFAZODONE; NEUROLEPTIC AGENT; NOOTROPIC AGENT; PHYSOSTIGMINE; RITANSERIN; RIVASTIGMINE; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; TACRINE; TIANEPTINE; TRAZODONE; UNINDEXED DRUG; ZALEPLON; ZOLPIDEM; ZOPICLONE;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; BRAIN FUNCTION; CATECHOLAMINE DEPLETION; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; COGNITION; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; DRUG MECHANISM; DRUG RESEARCH; ELECTROENCEPHALOGRAM; HUMAN; INSOMNIA; NEUROTRANSMISSION; NEUROTRANSMITTER UPTAKE; NONHUMAN; NORADRENERGIC SYSTEM; POLYSOMNOGRAPHY; PSYCHOPHARMACOLOGY; REM SLEEP; SEROTONINERGIC SYSTEM; SLEEP DISORDER; SLEEP WAKING CYCLE; SLOW WAVE SLEEP;

EID: 0038670222     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (96)

1. Bixler EO, Kales A, Soldatos CR, Kales JD, Healy S. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry. 1979;136:1257-1262.
2. Mellinger GD, Balter MB, Uhlenhut EH. Insomnia and its treatment. Prevalence and correlates. Arch Gen Psychiatry. 1985;42;225-232.
3. Ohayon MM. Epidemiological study on insomnia in a general population. Sleep. 1996:S7-S15.
4. National Center for Health Statistics. Selected symptoms of psychological distress. US Public Health Service Publication 1000, series 11, Number 37. US Department of Health, Education and Welfare: Washington, DC; 1970.
5. Balter MB, Bauer ML. Patterns of prescribing and use of hypnotic drugs in the United States. In: Clift AD, ed. Sleep Disturbances and Hypnotic Drug Dependence. New York, NY: Excerpta Medica; 1975.
6. Johnson LC, Spinweber CL. Quality of sleep and performance in the navy: a longitudinal study of good and poor sleepers. In: Guilleminault C, Lugaresi E, eds. Sleep/wake Disorders: Natural History, Epidemiology and Long-term Evolution. New York, NY: Raven Press; 1983:13-28.
7. Hammond E, Garfinkel L. Coronary heart disease, stroke and aortic aneurysm. Factors in the etiology. Arch Environ Health.1969;19:167-182.
8. Belloc NB. Relationship between health practice and mortality. Prev Med. 1973;2:67-81.
9. Kripke DF, Garfinkel L, Wingard DL, Kauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002;59:131-136.
10. Sejnowski TJ, Destexhe A. Why do we sleep? Brain Res. 2000;886:208-223.
11. Steriade M. Corticothalamic resonance, states of vigilance and mentation. Neuroscience. 2000;101:243-276.
12. Saper CB, Chou TC, Scammel TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24:726-731.
13. Mignot E, Taheri S, Hishino S. Sleeping with the hypothalamus: emerging therapeutics targets for sleep disorders. Nat Neurosci. 2002;5:1071-1075.
14. Perry E, Walker M, Grace J, Perry R. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci. 1999;22:273-280.
15. Aserinsky E, Kleitman N. Regularly occurring episodes of eye motility and concomitant phenomena during sleep. Science. 1953;118:273-274.
16. Jouvet M. The role of monoamines and acetylcholine containing neurones in the regulation of sleep waking cycle. Ergebnisse der Physiologie. 1972;64:166-307.
17. Shiromani PJ, Gillin JC, Henriksen SJ. Acetylcholine and regulation of REM sleep: basic mechanisms and clinical implication for affective disorder and narcolepsy. Annu Rev Pharmacol Toxicol. 1987;27:137-156.
18. Hobson AJ, Stickgold R, Pare-Schott EF. The neuropsychology of REM sleep dreaming. Neuroreport. 1998;9:R1-R14.
19. Rye DB. Contributions of the pedunculopontine region to normal and altered REM sleep. Sleep. 1997;20:757-788.
20. Rao U, Lutchmansingh P, Poland RE. Age-related effects of scopolamine on REM sleep regulation in normal control subjects: relationship to sleep abnormalities in depression. Neuropsychopharmacology. 1999;21:723-730.
21. Sitaram N, Mendelson WB, Wyatt RJ, Gillin JC. The time-dependent induction of REM sleep and arousal by physostigmine infusion during normal human sleep. Brain Res. 1977;122:562-567.
22. Riemann D, Lis S, Fritsch-Montero R, et al. Effect of tetrahydroaminoacridine on sleep in healthy subjects. Biol Psychiatry. 1996;39:796-802.
23. Holsboer-Trachsler E, Hatzinger M, Stohler R, et al. Effects of the novel acetylcholinesterase inhibitor SDZ ENA 713 on sleep in man. Neuropsychopharmacology. 1993;8:87-92.
24. Schredl M, Weber B, Braus D, Heuser I. The effect of rivastigmine on sleep in elderly healthy subjects. Exp Gerontol. 2000;35:243-249.
25. Ringman JM, Simmons JH. Treatment of REM sleep behavior disorder with donepezil: a report of three cases. Neurology. 2000;55:870-871.
26. Tilley AJ, Wilkinson RT. The effects of a restricted sleep regime on the composition of sleep and performance. Psychophysiology. 1984;21:406-412.
27. Takahashi Y, Kipnis DM, Daughaday WH. Growth hormone secretion during sleep. J Clin Invest. 1968;47:2079-2090.
28. Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG. Human growth hormone release: relation to slow wave sleep and sleepwaking cycles. Science. 1969;165:513-515.
29. Nakanishi H, Sun Y, Nakamura RK, et al. Positive corelations between protein synthesis rates and deep sleep in Maccaca mulatta. Eur J Neurosci. 1997;9:271-279.
30. Trinder J, Kleinman J, Carrington M, et al. Autonomic activity during human sleep as a function of time and sleep stage. J Sleep Res. 2001;10:253-264.
31. Maquet P. Functional neuroimaging of normal human sleep by positron emission tomography. J Sleep Res. 2000;9:207-231.
32. Griffin WJ, Trinder J. Physical fitness, exercise and human sleep. Psychophysiology. 1978;15:447-450.
33. Bunnel DE, Bevier W, Horwarth SM. Effects of exhaustive exercise on sleep of men and women. Psychophysiology. 1983;20:50-58.
34. Edinger JD, Morey MC, Sullivan RJ, et al. Aerobic fitness, acute exercise and sleep in older men. Sleep. 1993;16:351-359.
35. Kattler H, Dijk DJ, Borbely AA. Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans. J Sleep Res. 1994;3:159-164.
36. Maquet P. The role of sleep in learning and memory. Science. 2001;294:1048-1052.
37. Jurado JL, Luna Villegas G, Buela-Casal G. Normal human subjects with slow reaction times and larger time estimations after waking have diminished delta sleep. EEG Clin Neurophysiol. 1989;73:124-128.
38. Crenshaw MC, Edinger JD. Slow-wave sleep and waking cognitive performance among older adults with and without insomnia complaints. Physiol Behav. 1999;66:485-492.
39. Miles LE, Dement WC. Sleep and aging. Sleep. 1980;3:119-220.
40. Agnew HW, Webb WB, Williams RL. Sleep patterns in late middle age males: an EEG study. EEG Clin Neurophysiol. 1967;23:168-171.
41. Knowles JB, McLean AW. Age-related changes in sleep in depressed and healthy subjects: a meta-analysis. Neuropsychopharmacology. 1990;3:257-259.
42. Carskadon MA, Brown ED, Dement WC. Sleep fragmentation in the elderly: relationship to daytime sleep tendency. Neurobiol Aging. 1982;3:321-327.
43. Prinz PN. Sleep patterns in healthy aged: relationship with intellectual function. J Gerontol. 1977;32:179-186.
44. Feinberg I. Changes in sleep cycle patterns with age. J Psychiatry Res. 1974;10:283-306.
45. Borbely AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1:195-204.
46. Dijk DJ, Duffy JF, Czeisler CA. Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases. Sleep. 2001;24:565-577.
47. Jouvet M, Denoyer M, Kitahama K, Sallanon M. Slow wave sleep and indolamines: a hypothalamic target. In: Wauquier A, Dugovic C, Radulovacki, eds. Slow Wave Sleep. Physiological, Pathophysiological and Functional Aspects. New York, NY: Raven Press; 1989:91-107.
48. Sharpley AL, Cowen PJ. Effects of pharmacologic treatment on the sleep of depressed patients. Biol Psychiatry. 1995;37:85-98.
49. Landolt HP, Meier V, Burgess HJ, et al. Serotonin-2 receptors and human sleep: effect of a selective antagonist on EEG power spectra. Neuropsychopharmacology. 1999;21:455-466.
50. Viola AU, Brandenberger G, Toussaint M, Bouhours P, Macher JP, Luthringer R. Ritanserin, a serotonin-2 receptor antagonist, improves ultradian sleep rythmicity in young poor sleepers. Clin Neurophysiology. 2002;113:429-434.
51. Nicholson AN, Bradley CM, Pascoe PA. Medication effects on sleep and wakefulness. In: Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. Philadelphia, Pa: Saunders; 1989.
52. Staner L, Luthringer R, Macher JP. Effects of antidepressant drugs on sleep EEG in patients with major depression. Mechanisms and therapeutic implications. CNS Drugs. 1999;11:49-60.
53. Gaillard JM. Sommeil et psychotropes. J Pharmacol. 1984;15:389-399.
54. Wagner J, Wagner ML, Hening WA. Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Ann Pharmacother. 1998;32:680-691.
55. Adam K, Oswald I. Protein synthesis, bodily renewal and the sleep-wake cycle. Clin Sci. 1983;65:561-567.
56. 2 receptor blocker, as add-on tretament in narcolepsy. Sleep. 1991;14:130-132.
57. 2A/2C antagonist ritanserin on driving performance, slow wave sleep and daytime sleepiness in healthy volunteers. Psychopharmacology. 2001;154:189-197.
58. Gronfier C, Luthringer R, Follenius M, et al. A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep. 1996;19:817-824.
59. Katsuda Y, Walsch AE, Ware CJ. meta-Chlorophenylpiperazine decreases slow wave sleep in humans. Biol Psychiatry. 1993;33:49-51.
60. 2C receptors in vivo. Biol Psychiatry. 2000;47:468-470.
61. Staner L, Granier F, Vandenhende F, Macher JP, Luthringer R. Repeated administration of olanzapine differentially affects slow wave sleep, sleep continuity and daytime sedation: a placebo-controlled study of morning versus evening dosing in healthy volunteers. Eur Neuropsychopharmacol. 2002;12(suppl 3):S325.
62. Lindberg N, Virkunnen M, Tani P, et al. Effect of a single-dose of olanzapine on sleep in healthy females and males. Int Clin Psychopharmacol. 2002;17:177-184.
63. Reynolds CF III, Kupfer DJ. Sleep research in affective illness: state of the art circa 1987. Sleep. 1987;10:199-215.
64. Buysse DJ, Kupfer DJ. Diagnostic and research applications of electroencephalographic sleep studies in depression: conceptual and methodological issues. J Nerv Ment Dis. 1990;178:405-414.
65. Kupfer DJ, Bulik CM, Grochocinski V. Relationship between EEG sleep measures and clinical ratings of depression. J Affect Disord. 1984;6:43-52.
66. Hubain P, Van Veeren C, Staner L, Mendlewicz J, Linkowski P. Neuroendocrine and sleep variables in major depressed patients: role of severity. Psychiatry Res. 1996;63:83-93.
67. Kerkhofs M, Kempenaers C, Linkowski P, De Martelaere V, Mendlewicz J. Multivariate study of sleep EEG in depression. Acta Psychiatrica Scand. 1988;77:463-468.
68. Fossion P, Staner L, Dramaix M, et al. Does sleep EEG data distinguish between UP, BPI or BPII depressions? An age- and gender-controlled study. J Affect Disord. 1998;49:181-187.
69. Hubain P, Souery D, Jönck L, et al. Relationship between the Newcastle scale and sleep polysomnographic variables in major depression: a controlled study. Eur Neuropsychopharmacol. 1995;5:129-134.
70. Stefos G, Staner L, Kerkhofs M, Hubain P, Mendlewicz J, Linkowski P. Shortened REM latency as a psychobiologic marker for psychotic depression? An age, gender and polarity controlled study. Biol Psychiatry. 1998;44:1314-1320.
71. Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49:651-668.
72. Insel TR, Gillin JC, Moore A, Mendelson WB, Loewenstein RJ, Murphy DL. The sleep of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1982;39:1372-1377.
73. Uhde TW, Roy-Byrne P, Gillin JC, et al. The sleep of patients with panic disorder. A preliminary report. Psychiatry Res. 1984;12:251-259.
74. Katz JL, Kuperberg A, Pollack CP, Walsch BT, Zumoff B, Weiner H. Is there a relationship between eating disorder and affective disorder? New evidence from sleep recordings. Am J Psychiatry. 1984;141:753-759.
75. Moeller FG, Gillin JC, Irwin M, Golshan S, Kripke DF, Schuckit M. A comparison of sleep EEGs in patients with primary major depression and major depression secondary to alcoholism. J Affect Disord. 1993;27:39-42.
76. Zarcone VP Jr, Benson KL, Berger PA. Abnormal rapid eye movement latencies in schizophrenia. Arch Gen Psychiatry. 1987;44:45-48.
77. McCarley RW. REM sleep and depression: common neurobiological control mechanisms. Am J Psychiatry. 1982;139:565-570.
78. Seeman R. Receptor Tables vol 2: Dissociation Constants for Neuroreceptors and Transporters. Toronto, Canada: SZ Research; 1993.
79. Hirschfeld RM. Efficacy of SSRIs and newer antidepressants in severe depression: comparison with TCA. J Clin Psychiatry. 1999;60:326-335.
80. Heninger GR, Delgado PL, Charney DS. The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry. 1996;29:2-11.
81. Coccaro EF, Kavoussi RJ, Cooper TB, Hauger R. Tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects. Psychopharmacology. 1998;138:9-15.
82. Bhatti T, Gillin JC, Seifritz E, et al. Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and sleep. Biol Psychiatry. 1998;43:52-59.
83. Moore P, Gillin JC, Bhatti T, et al. Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors. Arch Gen Psychiatry. 1998;55:534-539.
84. Vordeholzer U, Hornyak M, Thiel B, et al. Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects. Neuropsychopharmacology. 1998;18:112-124.
85. Landolt HP, Schnierow BJ, Kelsoe JR, Rappaport MH, Gillin JC. Phenelzine-induced suppression of REM sleep can be reversed by rapid tryptophan depletion. Sleep. 2000;23(suppl 2):A34.
86. Gaillard JM, de St Hilaire-Kafi S. Sleep, depression and the effects of antidepressant drugs. Acta Psychiatr Belg. 1985;85:561-567.
87. Winokur A, Gary AK, Rodner S, Rae-Red C, Fernando AT, Szuba MP. Depression, sleep physiology and antidepressant drugs. Depress Anxiety. 2001;14:19-28.
88. Luthringer R, Toussaint M, Schaltenbrand N, et al. A double-blind, placebocontrolled evaluation of the effects of orally administered venlafexine on sleep in inpatients with major depression. Psychopharmacol Bull. 1996;32:637-642.
89. Van Bemmel AL, Beersma DGM, Van Den Hoofdakker RH. Changes in EEG power density of NREM sleep in depressed patients during treatment with citalopram. J Sleep Res. 1993;2:156-162.
90. Van Bemmel AL, Beersma DGM, Van Den Hoofdakker RH. Changes in EEG power density of non-REM sleep in depressed patients during treatment with trazodone. J Affect Disord. 1995;35:11-19.
91. Schlosser R, Roschke J, Rossbach W, Benkert O. Conventional and spectral power analysis of all-night sleep EEG after subchronic treatment with paroxetine in helathy male volunteers. Eur Neuropsychopharmacol. 1998;8:273-278.
92. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 2000;886;172-189.
93. Aston-Jones G, Chen S, Zhu Y, Oshinsky ML. A neural circuit for circadian regulation of arousal. Nat Neurosci. 2001;4:732-738.
94. Dugovic C. Role of serotonin in sleep mechanisms. Rev Neurol (Paris). 2001;157:5S16-5S17.
95. Jouvet M. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999;21:24S-27S.
96. Cape EG, Jones BE. Differential modulation of high-frequency gammaelectroencephalogram activity and sleep-wake state by noradrenaline and serotonin microinjections into the region of cholinergic basalis neurons. J Neurosci. 1998;18:2653-2666.