Distinct mechanisms account for β-amyloid toxicity in PC12 and differentiated PC12 neuronal cells

Journal of Biomedical Science

Volumn 10, Issue 4, 2003, Pages 379-388

  Sung, Yen Jen ^a   Cheng, Chia Io ^b   Chen, Chaio Sung ^a   Huang, Hsien Bin ^c   Huang, Fong Lee ^a   Wu, Pei Chun ^a   Shiao, Ming Shi ^d   Tsay, Huey Jen ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHI MEI FOUNDATION HOSPITAL   (Taiwan)

^c NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Amyloid; Alzheimer's disease; Apoptosis; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTIOXIDANT; NERVE GROWTH FACTOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL PROTECTION; CELL STRAIN; CELL TYPE; CELL VIABILITY; CYTOTOXICITY; INCUBATION TIME; MICROSCOPY; MOLECULAR MECHANICS; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASES; CELL DIFFERENTIATION; CELL SURVIVAL; DNA FRAGMENTATION; NECROSIS; NERVE GROWTH FACTOR; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; REACTIVE OXYGEN SPECIES; VITAMIN E;

EID: 0038646319     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000071157     Document Type: Article

References (44)

1. Begley JG, Duan W, Chan S, Duff K, Mattson MP. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 72:1030-1039;1999.
2. Behl C, Davis JB, Klier FG, Schubert D. Amyloid β peptide induces necrosis rather than apoptosis. Brain Res 645:253-264;1994.
3. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-827;1994.
4. Cafe C, Torri C, Bertorelli L, Angeretti N, Lucca E, Forloni G, Marzatico F. Oxidative stress after acute and chronic application of β-amyloid fragment 25-35 in cortical cultures. Neurosci Lett 203:61-65;1996.
5. Cotman CW, Anderson AJ. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 10:19-45;1995.
6. Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 6:493-506;1996.
7. Ekinci FJ, Malik KU, Shea TB. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to β-amyloid. MAP kinase mediates β-amyloid-induced neurodegeneration. J Biol Chem 274:30322-30327;1999.
8. Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, Rydel RE. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant 'apoptotic' pattern of gene induction. J Neurosci 17:7736-7745;1997.
9. Funakoshi H, Yonemasu T, Nakano T, Matumoto K, Nakamura T. Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. J Neurosci Res 68:150-160;2002.
10. Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS. E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem 275:11553-11560;2000.
11. Good PF, Werner P, Hsu A, Olanow CW, Perl DP. Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149:21-28;1996.
12. Isacson O, Seo H, Lin L, Albeck D, Granholm AC. Alzheimer's disease and Down's syndrome: Roles of APP, trophic factors and ACh. Trends Neurosci 25:79-84;2002.
13. Kim HY, Akbar M, Lau A, Edsall L. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in anti-apoptotic effect. J Biol Chem 275:35215-35223;2000.
14. Li J, Lee JM, Johnson JA. Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 Cells. J Biol Chem 277:388-394;2001.
15. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK. β-Amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res 738:196-204;1996.
16. 25-35 peptide-mediated neurotoxicity in rat hippocampal cultures. J Neurosci Res 39:494-505;1994.
17. Lucca E, Angeretti N, Forloni G. Influence of cell culture conditions on the protective effect of antioxidants against β-amyloid toxicity: Studies with lazaroids. Brain Res 764:293-298;1997.
18. 2+ channel activity by β-amyloid (1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1β. J Biol Chem 275:4713-4718;2000.
19. Magnani E, Bettini E. Resazurin detection of energy metabolism changes in serum-starved PC12 cells and of neuroprotective agent effect. Brain Res Brain Res Protoc 5:266-272;2000.
20. Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23:134-147;1997.
21. Mattson MP, Partin J, Begley JG. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites. Brain Res 807:167-176;1998.
22. Murphy GM Jr, Yang L, Cordell B. Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J Biol Chem 273:20967-20971;1998.
23. Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci USA 89:1671-1675;1992.
24. Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci 17:1683-1690;1997.
25. Pereira C, Santos MS, Oliveira C. Involvement of oxidative stress on the impairment of energy metabolism induced by Aβ peptides on PC12 cells: Protection by antioxidants. Neurobiol Dis 6:209-219;1999.
26. Pike CJ, Ramezan-Arab N, Cotman CW. β-Amyloid neurotoxicity in vitro: Evidence of oxidative stress but not protection by antioxidants. J Neurochem 69:1601-1611;1997.
27. Praprotnik D, Smith MA, Richey PL, Vinters HV, Perry G. Plasma membrane fragility in dystrophic neurites in senile plaques of Alz-heimer's disease: An index of oxidative stress. Acta Neuropathol (Berl) 91:1-5;1996.
28. Pratico D, Uryu K, Leight S, Trojanoswki JQ, Lee VM. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 21:4183-4187;2001.
29. Raina AK, Takeda A, Nunomura A, Perry G, Smith MA. Genetic evidence for oxidative stress in Alzheimer's disease. Neuroreport 10:1355-1357;1999.
30. Rothe G, Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J Leukoc Biol 47:440-448;1990.
31. Satoh T, Sakai N, Kubo T, Enokido Y, Uchiyama Y, Hatanaka H. Flow cytometric analysis of serum deprivation-induced apoptosis of PC12 cells, with special reference to role of bcl-2. Neurosci Lett 201:119-122;1995.
32. Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81:741-766;2001.
33. Simonian NA, Coyle JT. Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36:83-106;1996.
34. Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochim Biophys Acta 1502:139-144;2000.
35. Sohal RS, Dubey A. Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic Biol Med 16:621-626;1994.
36. Subbarao KV, Richardson JS, Ang LC. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 55:342-345;1990.
37. L inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells. Neurosci Lett 272:5-8;1999.
38. Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 mediates neuronal cell death induced by β-amyloid. J Neurosci 20:1386-1392;2000.
39. 2+ channels: A possible involvement of free radicals. J Neurochem 68:265-271;1997.
40. Varadarajan S, Yatin S, Aksenova M, Butterfield DA. Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130:184-208;2000.
41. Wang CN, Chi CW, Lin YL, Chen CF, Shiao YJ. The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J Biol Chem 276:5287-5295;2001.
42. White AR, Zheng H, Galatis D, Maher F, Hesse L, Multhaup G, Beyreuther K, Masters CL, Cappai R. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-β toxicity and oxidative stress. J Neurosci 18:6207-6217;1998.
43. 2 generation. J Neurochem 67:1595-1606;1996.
44. Zhou Y, Gopalakrishnan V, Richardson JS. Actions of neurotoxic β-amyloid on calcium homeostasis and viability of PC12 cells are blocked by antioxidants but not by calcium channel antagonists. J Neurochem 67:1419-1425;1996.