Bcl-x(L) inhibits apoptosis and necrosis produced by Alzheimer's β-amyloid1-40 peptide in PC12 cells

Neuroscience Letters

Volumn 272, Issue 1, 1999, Pages 5-8

  Asoh, Sadamitsu ^a   Mori, Takashi ^a   Ohta, Shigeo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

amyloid; Alzheimer's disease; Apoptosis; Bcl 2; Bcl x(L); PC12 cell

Indexed keywords

AMYLOID BETA PROTEIN; NERVE GROWTH FACTOR; PROTEIN BCL 2; PROTEIN BCL X; AMYLOID BETA PROTEIN[1-40]; BCL2L1 PROTEIN, RAT; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; WESTERN BLOTTING; ANIMAL; CELL STRAIN; GENETIC TRANSFECTION; GENETICS; NECROSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BCL-X PROTEIN; NECROSIS; NERVE GROWTH FACTOR; PC12 CELLS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TRANSFECTION;

EID: 0033520151     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00525-X     Document Type: Article

References (17)

1. Arnold D., Feng L., Kim J., Heintz N. A strategy for the analysis of gene expression during neural development. Proc. Natl. Acad. Sci. USA. 91:1994;9970-9974.
2. Asoh S., Lee-Kwon W., Mouradian M.M., Nirenberg M. Selection of DNA clones with enhancer sequences. Proc. Natl. Acad. Sci. USA. 91:1994;6982-6986.
3. Barbin G., Manthorpe M., Varon S. Purification of the chick eye ciliary neuronotrophic factor. J. Neurochem. 43:1984;1468-1478.
4. Barde Y.A., Edger D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1:1982;549-553.
5. Chen D.F., Schneider G.E., Martinou J.C., Tonegawa S. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature. 385:1997;434-439.
6. Diekmann S., Nitsch R., Ohm T.G. The organotypic entorhinalhippocampal complex slice culture of adolescent rat. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders. J. Neural. Transm. (Suppl). 44:1994;61-71.
7. Duboise-Dauphin M., Frankowski H., Tsujimoto Y., Huarte J., Martinou J.C. Neonatal motoneurones over-expressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl. Acad. Sci. USA. 91:1994;3309-3313.
8. Ishibashi Y., Nishimaki K., Asoh S., Nanbu-Wakao R., Yamada T., Ohta S. Pore formation domain of human pro-apoptotic Bax induces mammalian apoptosis as well as bacterial death without antagonizing ant-apoptoic factors. Biochem. Biopys. Res. Commun. 243:1998;609-616.
9. Levi Montalcini. Developmental neurobiology and the natural history of nerve growth factor. Ann. Rev. Neurosci. 5:1982;341-362.
10. Lin L.F.H., Doherty D.H., Lile J.D., Bektesh S., Collins E. A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1132.
11. Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science. 247:1990;1446-1451.
12. Martinou J.C., Dubois-Dauphin M., Staple J.K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C., Huarte J. Overexpression of Bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030.
13. Merry D.E., Korsmeyer S.J. Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20:1997;245-267.
14. Sadoul R. Bcl-2 family members in the development and degenerative pathologies of the nervous system. Cell Death and Differentiation. 5:1998;805-815.
15. Sanford J.C., Smith F.D., Russel J.A. Optimizing the biolistic process for different biological applications. Methods Enzymol. 217:1993;483-509.
16. Shiraiwa N., Inohara N., Okada S., Yuzaki M., Shoji S., Ohta S. An additional form of rat Bcl-x, Bcl-xβ, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J. Biol. Chem. 271:1996;13258-13265.
17. Stoppini L., Buchs P-A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods. 37:1991;173-182.