Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/anion antiporter

Pharmaceutical Research

Volumn 15, Issue 3, 1998, Pages 411-416

  Yabuuchi, Hikaru ^a   Tamai, Ikumi ^a   Sai, Yoshimichi ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Anion exchanger; Benzoic acid; HEK 293; Intestinal transport; Monocarboxylic acid

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ANTIPORTER; BENZOIC ACID; BICARBONATE; BUTYRIC ACID; CARBOXYLIC ACID; CARRIER PROTEIN; CHLORIDE ION; NICOTINIC ACID; PROPIONIC ACID; VALPROIC ACID;

ANION EXCHANGE; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE BRUSH BORDER MEMBRANE; ISOTOPE LABELING; KINETICS; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACETIC ACID; ANIMALS; ANION TRANSPORT PROTEINS; ANTIPORTERS; BENZOATES; BENZOIC ACID; CELL LINE; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINES; ION TRANSPORT; MEMBRANE PROTEINS; MICE; MICROVILLI; NERVE TISSUE PROTEINS; TRANSFECTION;

EID: 0031949384     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011920213991     Document Type: Article

References (30)

1. +-cotransport mechanism versus pH-partition hypothesis. J. Pharm. Sci. 12:1123-1124 (1990).
2. M. T. Simanjutak, T. Terasaki, I. Tamai, and A. Tsuji. Participation of monocarboxylic anion and bicarbonate exchange system for the tranport of acetic and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles. J. Pharmacobio-Dyn. 14:501-508 (1991).
3. A. Tsuji, H. Takanaga, I. Tamai, and T. Terasaki. Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 11:30-37 (1994).
4. H. Takanaga, I. Tamai, and A. Tsuji. pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells. J. Pharm. Pharmacol. 46:567-570 (1994).
5. H. Takanaga, H. Maeda, H. Yabuuchi, I. Tamai, H. Higashida, and A. Tsuji. Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane. J. Pharm. Pharmacol. 48:1073-1077 (1996).
6. I. Tamai, H. Takanaga, H. Maeda, H. Yabuuchi, Y. Sai, Y. Suzuki, and A. Tsuji. Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms. J. Pharm. Pharmacol. 49:108-112 (1997).
7. I. Tamai, H. Takanaga, H. Maeda, T. Ogihara, M. Yoneda, and A. Tsuji. Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm. Res. 12:1727-1732 (1995).
8. I. Tamai, and A. Tsuji. Carrier-mediated approaches for oral drug delivery. Adv. Drug Delivery Rev. 20:5-32 (1996).
9. H. Takanaga, I. Tamai, S. Inaba, Y Sai, H. Higashida, H. Yamamoto, and A. Tsuji. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem. Biophys. Res. Commun. 217:370-377 (1995).
10. I. Tamai, H. Takanaga, H. Maeda, Y. Sai, T. Ogihara, H. Higashida, and A. Tsuji. Participation of a proton-cotransporter, MCTI, in the intestinal transport of monocarboxylic acids. Biochem. Biophys. Res. Commun. 214:482-489 (1995).
11. - exchanger. J. Biol. Chem. 265:462-471 (1990).
12. D. R. Demuth, L. C. Showe, M. Ballantine, A. Palumbo, P. J. Fraser, L. Cioe, G. Rovera, and P. J. Curtis. Cloning and structural characterization of human non-erythroid band 3-like protein. EMBO J. 5:1205-1214 (1986).
13. S. L. Alper, R. R. Kopito, S. M. Libresco, and H. F. Lodish. Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J. Biol. Chem. 263:17092-17099 (1988).
14. H. Gehrig, W. Muler, and H. Appelhans. Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. Biochim. Biophys. Acta 1130:326-328 (1992).
15. A. E. Lindsey, K. Schneider, D. M. Simmons, R. Baron, B. S. Lee, and R. R. Kopito. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc. Natl. Acad. Sci. USA 87:5278-5282 (1990).
16. A. Chow, J. W. Dobbins, P. S. Aronson, and P. Igarashi. cDNA cloning and localization of band 3-related protein from ileum. Am. J. Physiol. 263:G345-352 (1992).
17. R. C. Poole and A. P. Halestrap. Transport of lactate and other monocarboxylates across mammalian plasma membrane. Am. J. Physiol. 264:C761-C782 (1993).
18. N. Hamasaki, H. Matsuyama, and C. Hirota-Chigita. Characterization of phosphoenolpyruvate transport across the erythrocyte membrane. Eur. J. Biochem. 132:531-536 (1983).
19. Y. Matsumoto and M. Ohsako. Transport of drugs through human erythrocyte membranes: pH dependence of drug transport through labeled human erythrocytes in the presence of band 3 protein inhibitor. J. Pharm. Sci. 81:428-431 (1992).
20. T. Minami and D. J. Cutler. A kinetic study of the role of band 3 anion transport protein in the transport of salicylic acid and other hydroxybenzoic acids across the human erythrocyte membrane. J. Pharm. Sci. 81:424-427 (1992).
21. M. Ohsako, Y. Matsumoto, and S. Goto. Transport of aspirin and its metabolites through human erythrocyte membrane. Biol. Pharm. Bull. 16:154-157 (1993).
22. B. S. Lee, R. B. Gunn, and R. R. Kopito. Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line. J. Biol. Chem. 266:11448-11454 (1991).
23. F. L. Graham and J. Smiley. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-72 (1977).
24. F. L. Graham and A. J. van der Eb. A new technique for the assay of infectivity of human-adenovirus 5 DNA. Virology 52:456-467 (1973).
25. J. R. Sanes, J. L. R. Rubenatein, and J.-F. Nicolas. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 5:3133-3142 (1986).
26. S. Ruetz, A. E. Lindsey, C. L. Ward, and R. R. Kopito. Functional activation of plasma membrane anion exchangers occurs in a pregolgi compartment. J. Cell Biol. 121:37-48 (1993).
27. S.-T. Alan, C. Sardet, J. Pouyssegur, M. A. Schwartz, D. Brown, and S. L. Alper. Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. Am. J. Physiol. 266:C559-568 (1994).
28. I. Sekler, R. S. Lo, and R. R. Kopito. A conserved glutamate is responsible for ion selectivity and pH dependence of the mammalian anion exchanger AE1 and AE2. J. Biol. Chem. 270:28751-28758 (1995).
29. I. Sekler, S. Kobayashi, and R. R. Kopito. A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger Cell 86:929-935 (1996).
30. R. G. Knickelbein, P. S. Aronson, and J. W. Dobbins. Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum. J. Clin. Invest. 82:2158-2163 (1988).