The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity

Journal of Experimental Medicine

Volumn 197, Issue 11, 2003, Pages 1551-1561

  Westgaard, Ingunn H ^a   Dissen, Erik ^a   Torgersen, Knut M ^b   Lazetic, Sasha ^c   Lanier, Lewis L ^c,d   Phillips, Joseph H ^c   Fossum, Sigbjørn ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Immunological receptors; Lymphocytes; Molecular sequence data; Natural immunity; Protein tyrosine phosphatase

Indexed keywords

CD3 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G; INTERLEUKIN 2; LECTIN RECEPTOR; PERVANADATE; PROTEIN; PROTEIN ITIM; PROTEIN KLRE1; PROTEIN TYROSINE PHOSPHATASE SHP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; IMMUNORECEPTOR TYROSINE BASED INHIBITORY MOTIF; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; RAT; STRAIN DIFFERENCE; T LYMPHOCYTE SUBPOPULATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CLONING, MOLECULAR; COS CELLS; DNA, COMPLEMENTARY; FEMALE; KILLER CELLS, NATURAL; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; PHYLOGENY; RATS; RATS, INBRED STRAINS; RECEPTORS, MITOGEN; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSFECTION;

EID: 0038620458     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021253     Document Type: Article

References (47)

1. Biron, C.A., K.B. Nguyen, G.C. Pien, L.P. Cousens, and T.P. Salazar-Mather. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189-220.
2. Cerwenka, A., and L.L. Lanier. 2001. Natural killer cells, viruses and cancer. Nat. Rev. Immunol. 1:41-49.
3. Rolstad, B., J.T. Vaage, C. Naper, D. Lambracht, K. Wonigeit, E. Joly, and G.W. Butcher. 1997. Positive and negative MHC class I recognition by rat NK cells. Immunol. Rev. 155:91-104.
4. Lanier, L.L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359-393.
5. Diefenbach, A., and D.H. Raulet. 2001. Strategies for target cell recognition by natural killer cells. Immunol. Rev. 181:170-184.
6. Karlhofer, F.M., R.K. Ribaudo, and W.M. Yokoyama. 1992. MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature. 358:66-70.
7. Arase, H., E.S. Mocarski, A.E. Campbell, A.B. Hill, and L.L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 296:1323-1326.
8. Moretta, A., S. Sivori, M. Vitale, D. Pende, L. Morelli, R. Augugliaro, C. Bottino, and L. Moretta. 1995. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J. Exp. Med. 182:875-884.
9. Mason, L.H., S.K. Anderson, W.M. Yokoyama, H.R. Smith, R. Winkler-Pickett, and J.R. Ortaldo. 1996. The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184:2119-2128.
10. Lanier, L.L., B. Corliss, J. Wu, and J.H. Phillips. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 8:693-701.
11. Bruhns, P., P. Marchetti, W.H. Fridman, E. Vivier, and M. Daeron. 1999. Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors. J. Immunol. 162:3168-3175.
12. Burshtyn, D.N., A.M. Scharenberg, N. Wagtmann, S. Rajagopalan, K. Berrada, T. Yi, J.P. Kinet, and E.O. Long. 1996. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity. 4:77-85.
13. Olcese, L., P. Lang, F. Vely, A. Cambiaggi, D. Marguet, M. Blery, K.L. Hippen, R. Biassoni, A. Moretta, L. Moretta, et al. 1996. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol. 156:4531-4534.
14. Fry, A.M., L.L. Lanier, and A. Weiss. 1996. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J. Exp. Med. 184:295-300.
15. Campbell, K.S., M. Dessing, M. Lopez-Botet, M. Cella, and M. Colonna. 1996. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. J. Exp. Med. 184:93-100.
16. Nakamura, M.C., E.C. Niemi, M.J. Fisher, L.D. Shultz, W.E. Seaman, and J.C. Ryan. 1997. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J. Exp. Med. 185:673-684.
17. Brown, M.G., S. Fulmek, K. Matsumoto, R. Cho, P.A. Lyons, E.R. Levy, A.A. Scalzo, and W.M. Yokoyama. 1997. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics. 42:16-25.
18. Dissen, E., J.C. Ryan, W.E. Seaman, and S. Fossum. 1996. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic: lymphocytes. J. Exp. Med. 183:2197-2207.
19. Renedo, M., I. Arce, K. Montgomery, P. Roda-Navarro, E. Lee, R. Kucherlapati, and E. Fernandez-Ruiz. 2000. A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2. Genomics. 65:129-136.
20. Lazetic, S., C. Chang, J.P. Houchins, L.L. Lanier, and J.H. Phillips. 1996. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 157:4741-4745.
21. Le Drean, E., F. Vely, L. Olcese, A. Cambiaggi, S. Guia, G. Krystal, N. Gervois, A. Moretta, F. Jotereau, and E. Vivier. 1998. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur. J. Immunol. 28:264-276.
22. Carretero, M., G. Palmieri, M. Llano, V. Tullio, A. Santoni, D.E. Geraghty, and M. Lopez-Botet. 1998. Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A: evidence for receptor function in heterologous transfectants. Eur. J. Immunol. 28:1280-1291.
23. Chang, C., and L.L. Lanier. 2000. Use of cDNA library expression cloning to identify components of heterodimeric receptor complexes. Methods Mol. Biol. 121:273-281.
24. Dissen, E., S.F. Berg, I.H. Westgaard, and S. Fossum. 1997. Molecular characterization of a gene in the rat homologous to human CD94. Eur. J. Immunol. 27:2080-2086.
25. Berg, S.F., E. Dissen, I.H. Westgaard, and S. Fossum. 1998. Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. Int. Immunol. 10:379-385.
26. Nicolls, M.R., G.G. Aversa, N.W. Pearce, A. Spinelli, M.F. Berger, K.E. Gurley, and B.M. Hall. 1993. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation. 55:459-468.
27. Hünig, T., H.J. Wallny, J.K. Hartley, A. Lawetzky, and G. Tiefenthaler. 1989. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med. 169:73-86.
28. Dallman, M.J., M.L. Thomas, and J.R. Green. 1984. MRC OX-19: a monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses. Eur. J. Immunol. 14:260-267.
29. McMaster, W.R., and A.F. Williams. 1979. Identification of Ia glycoproteins in rat thymus and purification from rat spleen. Eur. J. Immunol. 9:426-433.
30. McKnight, A.J., and B.J. Classon. 1992. Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4. Immunology. 75:286-292.
31. Chambers, W.H., N.L. Vujanovic, A.B. DeLeo, M.W. Olszowy, R.B. Herberman, and J.C. Hiserodt. 1989. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells. J. Exp. Med. 169:1373-1389.
32. Williams, A.F., G. Galfrè, and C. Milstein. 1977. Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell. 12:663-673.
33. Brideau, R.J., P.B. Carter, W.R. McMaster, D.W. Mason, and A.F. Williams. 1980. Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 10:609-615.
34. Damoiseaux, J.G., E.A. Dopp, W. Calame, D. Chao, G.G. MacPherson, and C.D. Dijkstra. 1994. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology. 83:140-147.
35. Barsumian, E.L., C. Isersky, M.G. Petrino, and R.P. Siraganian. 1981. IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. Eur. J. Immunol. 11:317-323.
36. Reynolds, C.W., E.W. Bere, Jr., and J.M. Ward. 1984. Natural killer activity in the rat. III. Characterization of transplantable large granular lymphocyte (LGL) leukemias in the F344 rat. J. Immunol. 132:534-540.
37. Spruyt, L.L., M.J. Glennie, A.D. Beyers, and A.F. Williams. 1991. Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16). J. Exp. Med. 174:1407-1415.
38. Pende, D., S. Parolini, A. Pessino, S. Sivori, R. Augugliaro, L. Morelli, E. Marcenaro, L. Accame, A. Malaspina, R. Biassoni, et al. 1999. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 190:1505-1516.
39. Hunt, S.V., and M.H. Fowler. 1981. A repopulation assay for B and T lymphocyte stem cells employing radiation chimaeras. Cell Tissue Kinet. 14:445-464.
40. Arase, H., T. Saito, J.H. Phillips, and L.L. Lanier. 2001. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J. Immunol. 167:1141-1144.
41. Vaage, J.T., C. Naper, G. Lovik, D. Lambracht, A. Rehm, H.J. Hedrich, K. Wonigeit, and B. Rolstad. 1994. Control of rat natural killer cell-mediated allorecognition by a major histocompatibility complex region encoding nonclassical class I antigens. J. Exp. Med. 180:641-651.
42. Berg, S.F., E. Dissen, I.H. Westgaard, and S. Fossum. 1998. Two genes in the rat homologous to human NKG2. Eur. J. Immunol. 28:444-450.
43. Naper, C., S. Hayashi, G. Løvik, L. Kveberg, E.C. Niémi, B. Rolstad, E. Dissen, J.C. Ryan, and J.T. Vaage. 2002. Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat natural killer cells. J. Immunol. 168:5147-5154.
44. Boyington, J.C., A.N. Riaz, A. Patamawenu, J.E. Coligan, A.G. Brooks, and P.D. Sun. 1999. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. Immunity. 10:75-82.
45. Tormo, J., K. Natarajan, D.H. Margulies, and R.A. Mariuzza. 1999. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature. 402:623-631.
46. Li, P., D.L. Morris, B.E. Willcox, A. Steinle, T. Spies, and R.K. Strong. 2001. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2:443-451.
47. Radaev, S., B. Rostro, A.G. Brooks, M. Colonna, and P.D. Sun. 2001. Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Immunity. 15:1039-1049.