Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes

Journal of Antimicrobial Chemotherapy

Volumn 52, Issue 1, 2003, Pages 24-28

  Garcia I ^a   Pascual, A ^a,b   Ballesta, S ^a   del Castillo, C ^b   Perea, E J ^a,b  

^a School of Medicine   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

Intracellular activity; Intracellular concentration; Ketolides; Phagocytes

Indexed keywords

2,4 DINITROPHENOL; ANTIINFECTIVE AGENT; AZITHROMYCIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CETHROMYCIN; ERYTHROMYCIN DERIVATIVE; KETOLIDE; MACROLIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL PH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DRUG ACCUMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG UPTAKE; ENVIRONMENTAL TEMPERATURE; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; INCUBATION TIME; INTRACELLULAR SPACE; ISOTOPE LABELING; POLYMORPHONUCLEAR CELL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRAIN DIFFERENCE;

EID: 0038601497     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg290     Document Type: Article

References (29)

1. Vazifeh, D., Abdelghaffar, H. & Labro, M. T. (1997). Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithomycin and roxithromycin. Antimicrobial Agents and Chemotherapy 41, 2099-107.
2. Vazifeh, D., Preira, A., Bryskier, A. et al. (1998). Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils. Antimicrobial Agents and Chemotherapy 42, 1944-51.
3. Pascual, A., Ballesta, S., García, I. et al. (2001). Uptake and intracellular activity of ketolide HMR 3647 in human phagocytic and non-phagocytic cells. Clinical Microbiology and Infection 7, 65-9.
4. Abdelghaffar, H., Vazifeh, D. & Labro, M. T. (2001). Cellular uptake of two fluoroketolides, HMR 3562 and HMR 3787, by human polymorphonuclear neutrophils in vitro. Antimicrobial Agents and Chemotherapy 45, 2798-806.
5. Pascual, A., Conejo, M. C., Garcia, I. et al. (1995). Factors affecting the intracellular accumulation and activity of azithromycin. Journal of Antimicrobial Chemotherapy 35, 85-93.
6. Labro, M. T. (1997). Effects of macrolides on leukocytes and inflammation. In Expanding Indications of the New Macrolides, Azalides and Streptogramins (Zinner, S., Young, S. & Acar, J., Eds), pp. 101-16. Marcel Dekker, Inc., New York, NY, USA.
7. Labro, M. T. (1996). Intracellular bioactivity of macrolides. Clinical Microbiology and Infection 1, Suppl. 1, S24-S30.
8. Barrett, J. F. & Dougherty, T. J. (2001). ABT-773: a new ketolide antibiotic. Expert Opinion on Investigational Drugs 10, 343-51.
9. Andrews, J. M., Weller, T. M., Ashby, J. P. et al. (2000). The in vitro activity of ABT773, a new ketolide antimicrobial agent. Journal of Antimicrobial Chemotherapy 46, 1017-22.
10. Brueggemann, A. B., Doer, G. V., Huynh, H. K. et al. (2000). In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus Influenzae and Moraxella catarrhalis. Antimicrobial Agents and Chemotherapy 44, 447-9.
11. Jung, R., Danziger, L. H. & Pendland, S. L. (2002). Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila. Journal of Antimicrobial Chemotherapy 49, 857-61.
12. Finegold, S. M., Molitoris, D., Phan, V. T. et al. (2002). Activities of ABT-773 against microaerophilic and fastidious organisms. Antimicrobial Agents and Chemotherapy 46, 2716-9.
13. Shortridge, V. D., Zhong, P., Cao, Z. et al. (2002). Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci. Antimicrobial Agents and Chemotherapy 46, 783-6.
14. Schmitz, F. J., Schwarz, S., Milatovic, D. et al. (2002). In vitro activities of the ketolides ABT-773 and telithromycin and of three macrolides against genetically characterized isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis. Journal of Antimicrobial Chemotherapy 50, 145-8.
15. Peterson, P. K., Verhoef, J., Schmeling, D. et al. (1997). Kinetics of phagocytosis and bacterial killing by human polymorphonuclear leukocytes and monocytes. Journal of Infectious Diseases 136, 502-9.
16. Klempner, M. S. & Styrt, B. (1981). Clindamycin uptake by human neutrophils. Journal of Infectious Diseases 144, 472-5.
17. Pascual, A., García, I. & Perea, E. J. (1989). Fluorometric measurement of ofloxacin uptake by human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 33, 653-6.
18. Pascual, A., Tsakayama, D., Kovarik, J. et al. (1987). Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes. European Journal of Clinical Microbiology and Infectious Diseases 6, 152-7.
19. Douthwaite, S. & Champney, W. S. (2001). Structures of ketolides and macrolides determine their mode of interaction with their ribosomall target site. Journal of Antimicrobial Chemotherapy 48, Suppl. T1, 1-8.
20. Mtairag, E. M., Abdelghaffar, H. & Labro, M. T. (1994). Investigation of dirithromycylamine uptake by human neutrophils in vitro. Journal of Antimicrobial Chemotherapy 33, 523-36.
21. García, I., Pascual, A. & Perea, E. J. (1994). Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 38, 2426-9.
22. Hand, W. L. & Hand, D. L. (2001). Characteristics and mechanisms of azithromycin accumulation in human polymorphonuclear leukocytes. International Journal of Antimicrobial Agents 18, 419-25.
23. Vazifeh, D., Bryskier, A. & Labro, M. T. (2000). Effect of proinflammatory cytokines on the interplay between roxithromycin, HMR 3647, or HMR 3004 and human polymorphonuclear neutrophils. Antimicrobial Agents and Chemotherapy 44, 511-21.
24. Yamamori, T., Inanami, O., Nagahata, H. et al. (2000). Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes. FEBS Letters 467, 253-8.
25. McLeish, K. R., Klein, J. B., Coxon, P. Y. et al. (1998). Bacterial phagocytosis activates extracellular signal-regulated kinase and p38-mitogen-activated protein kinase cascades in human neutrophils. Journal of Leucocyte Biology 64, 835-44.
26. Vazifeh, D., Abdelghaffar, H. & Labro, M. T. (2002). Effect of telithromycin (HMR 3647) on polymorphonuclear neutrophil killing of Staphylococcus aureus in comparison with roxithromycin. Antimicrobial Agents and Chemotherapy 46, 1364-74.
27. Milatovic, D. (1990). Intraphagocytic activity of erythromycin, roxithromycin and azithromycin. European Journal of Clinical Microbiology and Infectious Diseases 9, 33-5.
28. Boswell, F. J., Andrews, J. M. & Wise, R. (1998). Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect. Journal of Antimicrobial Chemotherapy 41, 149-53.
29. Casellas, J. M., Tomé, G., Visser, M. et al. (2002). In vitro activity of the new ketolide ABT-773 against community acquired respiratory tract isolates and Viridans streptococci. Diagnostic Microbiology and Infectious Disease 42, 1107-12.