Uptake and intracellular activity of ketolide HMR 3647 in human phagocytic and non-phagocytic cells

Clinical Microbiology and Infection

Volumn 7, Issue 2, 2001, Pages 65-69

  Pascual, A ^a   Ballesta, S ^a   Garcia I ^a   Perea, E J ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

HMR 3647; Intracellular activity; Intracellular penetration; Ketolide; Phagocytes; Tissue cultured

Indexed keywords

KETOLIDE; TELITHROMYCIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG UPTAKE; EPITHELIUM CELL; EXTRACELLULAR SPACE; FIBROBLAST; HUMAN; HUMAN CELL; INCUBATION TIME; MINIMUM INHIBITORY CONCENTRATION; NEUTROPHIL; PERITONEUM MACROPHAGE; PHAGOCYTE; PRIORITY JOURNAL; RADIOMETRY; STAPHYLOCOCCUS AUREUS; TISSUE CULTURE CELL;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0035262142     PISSN: 1198743X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-0691.2001.00213.x     Document Type: Article

References (19)

1. In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria
2. Susceptibilities of penicillin and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, compared with susceptibilities to 17 other agents
3. Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin and eight other antimicrobial agents against unusual aerobic and anaerobic bite pathogens isolated from skin and soft tissue infections in humans
4. Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004)
5. In vitro activity of a new ketolide antibiotic, HMR 3647, against Clamydia pneumoniae
6. In vitro activity of the ketolide HMR 3647 (RU 6647) for Legionella spp., its pharmacokinetics in guinea pigs, and use of the drug to treat guinea pigs with Legionella pneumophila pneumonia
7. The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection
8. Use of two ketolides in combination with other drugs to treat experimental toxoplasmosis
9. Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils
10. Kinetics of phagocytosis and bacterial killing by human polymorphonuclear leukocytes and monocytes
11. Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes
12. Clindamycin uptake by human neutrophils
13. The new ketolide HMR 3647 accumulates in the azurophil granules of human polymorphonuclear cells
14. Investigation of dirithromycylamine uptake by human neutrophils in vitro
15. Cellular accumulation of the new ketolide RU 64004 by neutrophils: Comparison with that of azithromycin and roxithromycin
16. Intracellular accumulation of azithromycin by cultured human fibroblast
17. Intracellular activity of erythromicin, roxithromycin and azithromycin
18. Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time kill kinetics and postantibiotic effect
19. Intracellular activity of HMR 3647, a new ketolide, against Streptococcus pneumoniae