Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantjbiotic effect

Journal of Antimicrobial Chemotherapy

Volumn 41, Issue 2, 1998, Pages 149-153

  Boswell, F J ^a   Andrews, J M ^a   Wise, R ^a  

^a CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIOSTASIS; BACTEROIDES FRAGILIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; POSTANTIBIOTIC EFFECT; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; BACTEROIDES FRAGILIS; ENTEROCOCCUS; HAEMOPHILUS INFLUENZAE; KETOLIDES; KINETICS; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MORAXELLA (BRANHAMELLA) CATARRHALIS; RESPIRATORY TRACT INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS;

EID: 0031942015     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. References
2. Agouridas, C., Benedetti, Y., Denis, A., Fromentin, C., Gouin D'Ambrieres, S., Le Martret, O. et al. (1994). Ketolides, a new distinct semi-synthetic class of macrolides. In Program of the Thirty-Fourth Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlandg, FL, 1994. Abstract F164, p. 227. American Society of Microbiology, Washington, DC.
3. Agouridas, C., Benedetti, Y., Denis, A., Le Martret, O. & Chantot, J. F. (1995). Ketolides: a new distinct class of macrolide antibacterials-synthesis and structural characteristics of RU 004. In Program of the Thirty-Fifth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, 1995. Abstract F157, p. 140. American Society of Microbiology, Washington, DC.
4. Agouridas, C., Bonnefoy, A. & Chantot, J. F. (1995). In vitro antibacterial activity of RU 004, a novel ketolide highly active against respiratory pathogens. In Program of the Thirty-Fifth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, 1995. Abstract F158, p. 140. American Society of Microbiology, Washington, DC.
5. National Committee for Clinical Laboratory Standards. (1992). Methods for Determining Bactericidal Activity of Antimicrobial Agents; Tentative Guideline M26-T. NCCLS, Villanova, PA.
6. Craig, W. A. & Gudmundsson, S. (1991). Postantibiotic effect. In Antibiotics in Laboratory Medicine, 3rd edn (Lorian, V., Ed.), pp. 403-31. Williams and Wilkins, Baltimore, MD.
7. Lambert, H. P. & O'Grady, F. W. (1992). Macrolides. In Antibiotic and Chemotherapy, 6th edn, pp 168-79. Churchill Livingstone, New York, NY.
8. Working Party Report of the British Society for Antimicrobial Chemotherapy. (1991). A guide to sensitivity testing. Journal of Antimicrobial Chemotherapy 27, Suppl. D, 22-30.
9. Miles, A. A., Misra, S. S. & Irwin, J. O. (1938). The estimation of the bactericidal power of the blood. Journal of Hygiene 38,732-49.
10. Odenholt-Tornqvist, I., Lowdin, E. & Cars, O. (1995). Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens. Antimicrobial Agents and Chemotherapy39,221-6.
11. Scaglione, F., Dugnani, S., Demartini, G., Sandelli, M., Galmozzi, G. & Fraschini, F. (1993). The postantibiotic effect of clarithromycin and its major human metabolite, 14 hydroxyclarithromycin. Journal of Antimicrobial Chemotherapy 32,507-9.
12. Boswell, F. J., Andrews, J. M. & Wise, R. (1994). The postantibiotic effect of RP 59500 on Staphylococcus aureus including strains with a raised MBC. Journal of Antimicrobial Chemotherapy 33,1219-22.
13. Received 30 June 1997; returned 5 August 1997; revised 15 August 1997; accepted 1 September 1997