Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells

Free Radical Biology and Medicine

Volumn 33, Issue 2, 2002, Pages 283-291

  Pirlich, Matthias ^a   Müller, Cornelia ^a   Sandig, Grit ^a   Jakstadt, Manuela ^a   Sitte, Nicolle ^a   Lochs, Herbert ^a   Grune, Tilman ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Ethanol; Free radicals; Hepatocytes; Oxidative stress; Proteasome; Proteolysis

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALKANE; BROMOTRICHLOROMETHANE; HYDROGEN PEROXIDE; KETOCONAZOLE; LACTACYSTIN; METHIONINE; PROTEASOME; PROTEASOME INHIBITOR; REACTIVE OXYGEN METABOLITE; SULFUR 35; CYSTEINE PROTEINASE; CYTOCHROME P450; ENZYME INHIBITOR; MULTIENZYME COMPLEX; PRIMER DNA; PROTEIN; RNA;

ALCOHOLISM; ARTICLE; CELL LABELING; CELL LEVEL; CELL LYSATE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER TOXICITY; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; LIVER CELL; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION;

BROMOTRICHLOROMETHANE; CELL SURVIVAL; CELLS, CULTURED; COMPARATIVE STUDY; CYSTEINE ENDOPEPTIDASES; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHANOL; HEPATOCYTES; HUMAN; HYDROGEN PEROXIDE; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEINS; REACTIVE OXYGEN SPECIES; RNA; SUPPORT, NON-U.S. GOV'T; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 0037098879     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00880-8     Document Type: Article

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