-
1
-
-
0032965338
-
Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness
-
Hamelmann E, Wahn U, Gelfand EW: Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness. Int Arch Allergy Immunol 1999;118:90-94.
-
(1999)
Int Arch Allergy Immunol
, vol.118
, pp. 90-94
-
-
Hamelmann, E.1
Wahn, U.2
Gelfand, E.W.3
-
2
-
-
15844404509
-
Essential role of Stat6 in IL-4 signalling
-
Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S: Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-630.
-
(1996)
Nature
, vol.380
, pp. 627-630
-
-
Takeda, K.1
Tanaka, T.2
Shi, W.3
Matsumoto, M.4
Minami, M.5
Kashiwamura, S.6
Nakanishi, K.7
Yoshida, N.8
Kishimoto, T.9
Akira, S.10
-
3
-
-
0034744486
-
TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression
-
Christodoulopoulos P, Cameron L, Nakamura Y, Lemiere C, Muro S, Dugas M, Boulet LP, Laviolette M, Olivenstein R, Hamid Q: TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression. J Allergy Clin Immunol 2001;107:586-591.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 586-591
-
-
Christodoulopoulos, P.1
Cameron, L.2
Nakamura, Y.3
Lemiere, C.4
Muro, S.5
Dugas, M.6
Boulet, L.P.7
Laviolette, M.8
Olivenstein, R.9
Hamid, Q.10
-
4
-
-
15844374279
-
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
-
Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN: Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-633.
-
(1996)
Nature
, vol.380
, pp. 630-633
-
-
Shimoda, K.1
Van Deursen, J.2
Sangster, M.Y.3
Sarawar, S.R.4
Carson, R.T.5
Tripp, R.A.6
Chu, C.7
Quelle, F.W.8
Nosaka, T.9
Vignali, D.A.10
Doherty, P.C.11
Grosveld, G.12
Paul, W.E.13
Ihle, J.N.14
-
5
-
-
0030587813
-
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
-
Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S: Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996;157:3220-3222.
-
(1996)
J Immunol
, vol.157
, pp. 3220-3222
-
-
Takeda, K.1
Kamanaka, M.2
Tanaka, T.3
Kishimoto, T.4
Akira, S.5
-
6
-
-
0032828226
-
The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5
-
Tomkinson A, Kanehiro A, Rabinovitch N, Joetham A, Cieslewicz G, Gelfand EW: The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5. Am J Respir Crit Care Med 1999;160:1283-1291.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 1283-1291
-
-
Tomkinson, A.1
Kanehiro, A.2
Rabinovitch, N.3
Joetham, A.4
Cieslewicz, G.5
Gelfand, E.W.6
-
7
-
-
0034641632
-
Control of T helper cell differentiation - In search of master genes
-
Dong C, Flavell RA: Control of T helper cell differentiation - in search of master genes. Sci STKE 2000;2000:PE1.
-
(2000)
Sci STKE
, vol.2000
-
-
Dong, C.1
Flavell, R.A.2
-
8
-
-
0032906187
-
GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
-
Ferber IA, Lee HJ, Zonin F, Heath V, Mui A, Arai N, O'Garra A: GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin Immunol 1999;91:134-144.
-
(1999)
Clin Immunol
, vol.91
, pp. 134-144
-
-
Ferber, I.A.1
Lee, H.J.2
Zonin, F.3
Heath, V.4
Mui, A.5
Arai, N.6
O'Garra, A.7
-
9
-
-
0035806279
-
Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
-
Finotto S, De Sanctis GT, Lehr HA, Herz U, Buerke M, Schipp M, Bartsch B, Atreya R, Schmitt E, Galle PR, Renz H, Neurath MF: Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med 2001;193:1247-1260.
-
(2001)
J Exp Med
, vol.193
, pp. 1247-1260
-
-
Finotto, S.1
De Sanctis, G.T.2
Lehr, H.A.3
Herz, U.4
Buerke, M.5
Schipp, M.6
Bartsch, B.7
Atreya, R.8
Schmitt, E.9
Galle, P.R.10
Renz, H.11
Neurath, M.F.12
-
10
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100:655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
11
-
-
0037059509
-
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
-
Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002;295:336-338.
-
(2002)
Science
, vol.295
, pp. 336-338
-
-
Finotto, S.1
Neurath, M.F.2
Glickman, J.N.3
Qin, S.4
Lehr, H.A.5
Green, F.H.6
Ackerman, K.7
Haley, K.8
Galle, P.R.9
Szabo, S.J.10
Drazen, J.M.11
De Sanctis, G.T.12
Glimcher, L.H.13
-
12
-
-
0032476742
-
Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
-
Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P: Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med 1998;188:1739-1750.
-
(1998)
J Exp Med
, vol.188
, pp. 1739-1750
-
-
Yang, L.1
Cohn, L.2
Zhang, D.H.3
Homer, R.4
Ray, A.5
Ray, P.6
-
13
-
-
0035222187
-
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
-
Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A: A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2001;2:45-50.
-
(2001)
Nat Immunol
, vol.2
, pp. 45-50
-
-
Das, J.1
Chen, C.H.2
Yang, L.3
Cohn, L.4
Ray, P.5
Ray, A.6
-
14
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD: Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-442.
-
(1996)
Cell
, vol.84
, pp. 431-442
-
-
Meraz, M.A.1
White, J.M.2
Sheehan, K.C.3
Bach, E.A.4
Rodig, S.J.5
Dighe, A.S.6
Kaplan, D.H.7
Riley, J.K.8
Greenlund, A.C.9
Campbell, D.10
Carver-Moore, K.11
DuBois, R.N.12
Clark, R.13
Aguet, M.14
Schreiber, R.D.15
-
15
-
-
0034604542
-
Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages
-
Nguyen VT, Benveniste EN: Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages. J Biol Chem 2000;275:23674-23684.
-
(2000)
J Biol Chem
, vol.275
, pp. 23674-23684
-
-
Nguyen, V.T.1
Benveniste, E.N.2
-
16
-
-
0034595683
-
Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727
-
Gamero AM, Larner AC: Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727. J Biol Chem 2000;275:16574-16578.
-
(2000)
J Biol Chem
, vol.275
, pp. 16574-16578
-
-
Gamero, A.M.1
Larner, A.C.2
-
17
-
-
0029005549
-
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
-
Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 1995;269:79-81.
-
(1995)
Science
, vol.269
, pp. 79-81
-
-
Migone, T.S.1
Lin, J.X.2
Cereseto, A.3
Mulloy, J.C.4
O'Shea, J.J.5
Franchini, G.6
Leonard, W.J.7
-
18
-
-
0029834676
-
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
-
Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM, Wasik MA: Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 1996;93:9148-9153.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9148-9153
-
-
Zhang, Q.1
Nowak, I.2
Vonderheid, E.C.3
Rook, A.H.4
Kadin, M.E.5
Nowell, P.C.6
Shaw, L.M.7
Wasik, M.A.8
-
19
-
-
0035017383
-
Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells
-
Eriksen KW, Kaltoft K, Mikkelsen G, Nielsen M, Zhang Q, Geisler C, Nissen MH, Ropke C, Wasik MA, Odum N: Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 2001;15:787-793.
-
(2001)
Leukemia
, vol.15
, pp. 787-793
-
-
Eriksen, K.W.1
Kaltoft, K.2
Mikkelsen, G.3
Nielsen, M.4
Zhang, Q.5
Geisler, C.6
Nissen, M.H.7
Ropke, C.8
Wasik, M.A.9
Odum, N.10
-
20
-
-
13344295097
-
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
-
Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM: Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996;379:645-648.
-
(1996)
Nature
, vol.379
, pp. 645-648
-
-
Meydan, N.1
Grunberger, T.2
Dadi, H.3
Shahar, M.4
Arpaia, E.5
Lapidot, Z.6
Leeder, J.S.7
Freedman, M.8
Cohen, A.9
Gazit, A.10
Levitzki, A.11
Roifman, C.M.12
-
21
-
-
0033135134
-
Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
-
Sampath D, Castro M, Look DC, Holtzman MJ: Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Invest 1999;103:1353-1361.
-
(1999)
J Clin Invest
, vol.103
, pp. 1353-1361
-
-
Sampath, D.1
Castro, M.2
Look, D.C.3
Holtzman, M.J.4
-
22
-
-
0037138520
-
Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs
-
Buchwald AB, Wagner AH, Webel C, Hecker M: Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs. J Am Coll Cardiol 2002;39:732-738.
-
(2002)
J Am Coll Cardiol
, vol.39
, pp. 732-738
-
-
Buchwald, A.B.1
Wagner, A.H.2
Webel, C.3
Hecker, M.4
-
23
-
-
0036075948
-
CCAAT/enhancer-binding protein decoy oligodeoxynucleotide inhibition of macrophage-rich vascular lesion formation in hypercholesterolemic rabbits
-
Kelkenberg U, Wagner AH, Sarhaddar J, Hecker M, von der Leyen HE: CCAAT/enhancer-binding protein decoy oligodeoxynucleotide inhibition of macrophage-rich vascular lesion formation in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol 2002;22:949-954.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 949-954
-
-
Kelkenberg, U.1
Wagner, A.H.2
Sarhaddar, J.3
Hecker, M.4
Von Der Leyen, H.E.5
-
24
-
-
0033619428
-
Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial
-
Mann MJ, Whittemore AD, Donaldson MC, Belkin M, Conte MS, Polak JF, Orav EJ, Ehsan A, Dell'Acqua G, Dzau VJ: Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: The PREVENT single-centre, randomised, controlled trial. Lancet 1999;354:1493-1498.
-
(1999)
Lancet
, vol.354
, pp. 1493-1498
-
-
Mann, M.J.1
Whittemore, A.D.2
Donaldson, M.C.3
Belkin, M.4
Conte, M.S.5
Polak, J.F.6
Orav, E.J.7
Ehsan, A.8
Dell'Acqua, G.9
Dzau, V.J.10
-
25
-
-
0033997932
-
Anti-inflammatory gene therapy directed at the airway epithelium
-
Griesenbach U, Scheid P, Hillery E, de Martin R, Huang L, Geddes DM, Alton EW: Anti-inflammatory gene therapy directed at the airway epithelium. Gene Ther 2000;7:306-313.
-
(2000)
Gene Ther
, vol.7
, pp. 306-313
-
-
Griesenbach, U.1
Scheid, P.2
Hillery, E.3
De Martin, R.4
Huang, L.5
Geddes, D.M.6
Alton, E.W.7
-
26
-
-
0034651874
-
Targeted disruption of stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response
-
Wang LH, Yang XY, Kirken RA, Resau JH, Farrar WL: Targeted disruption of stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response. Blood 2000;95:1249-1257.
-
(2000)
Blood
, vol.95
, pp. 1249-1257
-
-
Wang, L.H.1
Yang, X.Y.2
Kirken, R.A.3
Resau, J.H.4
Farrar, W.L.5
-
27
-
-
0032521148
-
Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice
-
Lei XF, Ohkawara Y, Stampfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M: Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. J Clin Invest 1998;101:1342-1353.
-
(1998)
J Clin Invest
, vol.101
, pp. 1342-1353
-
-
Lei, X.F.1
Ohkawara, Y.2
Stampfli, M.R.3
Mastruzzo, C.4
Marr, R.A.5
Snider, D.6
Xing, Z.7
Jordana, M.8
-
28
-
-
0025906476
-
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: Contributions of endothelial cell adhesion molecules
-
Bochner BS, Luscinskas FW, Gimbrone MA Jr, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP: Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: Contributions of endothelial cell adhesion molecules. J Exp Med 1991;173:1553-1557.
-
(1991)
J Exp Med
, vol.173
, pp. 1553-1557
-
-
Bochner, B.S.1
Luscinskas, F.W.2
Gimbrone M.A., Jr.3
Newman, W.4
Sterbinsky, S.A.5
Derse-Anthony, C.P.6
Klunk, D.7
Schleimer, R.P.8
|