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Volumn 14, Issue 2, 2002, Pages 91-101

The determinants of activated partial thromboplastin time, relation of activated partial thromboplastin time to clinical outcomes, and optimal dosing regimens for heparin treated patients with acute coronary syndromes: A review of GUSTO-IIb

Author keywords

Activated partial thromboplastin time; Acute coronary syndrome; Heparin

Indexed keywords

FIBRINOLYTIC AGENT; HEPARIN; HIRUDIN; THROMBOPLASTIN;

EID: 0038555393     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023235926825     Document Type: Article
Times cited : (30)

References (51)
  • 1
    • 0022620299 scopus 로고
    • Angiographic evaluation of coronary artery morphology in unstable angina
    • Ambrose JA, Winters SL, Arora RR, et al. Angiographic evaluation of coronary artery morphology in unstable angina. J Am Coll Cardiol 1986;7:474-478.
    • (1986) J Am Coll Cardiol , vol.7 , pp. 474-478
    • Ambrose, J.A.1    Winters, S.L.2    Arora, R.R.3
  • 4
    • 0026541706 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes [2]
    • Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes [2]. N Engl J Med 1992;36:310-318.
    • (1992) N Engl J Med , vol.36 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 5
    • 0035902456 scopus 로고    scopus 로고
    • Currents concepts of the pathogenesis of the acute coronary syndromes
    • Libby P. Currents concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001;104:365-372.
    • (2001) Circulation , vol.104 , pp. 365-372
    • Libby, P.1
  • 6
    • 0020308498 scopus 로고
    • Intracoronary thrombolysis in syndromes of unstable angina: Angiographic and clinical results
    • Vetrovec G, Leinback R, Gold HK, Cowley MJ. Intracoronary thrombolysis in syndromes of unstable angina: Angiographic and clinical results. Am Heart J 1982;104:946-952.
    • (1982) Am Heart J , vol.104 , pp. 946-952
    • Vetrovec, G.1    Leinback, R.2    Gold, H.K.3    Cowley, M.J.4
  • 7
    • 0020606828 scopus 로고
    • Intracoronary thrombs in nontransmural myocardial infarction and in unstable angina pectoris
    • Mandelkorn J, Wolf N, Singh S, et al. Intracoronary thrombs in nontransmural myocardial infarction and in unstable angina pectoris. Am J Cardiol 1983;52:1-6.
    • (1983) Am J Cardiol , vol.52 , pp. 1-6
    • Mandelkorn, J.1    Wolf, N.2    Singh, S.3
  • 8
    • 0022477264 scopus 로고
    • Coronary angioscopy in patients with unstable angina pectoris
    • Sherman CT, Litvack F, Gundfest T, et al. Coronary angioscopy in patients with unstable angina pectoris. N Eng J Med 1986;315:913-919.
    • (1986) N Eng J Med , vol.315 , pp. 913-919
    • Sherman, C.T.1    Litvack, F.2    Gundfest, T.3
  • 9
    • 0026541705 scopus 로고
    • Angioscopic evaluation of coronary artery thrombi in acute coronary syndromes
    • Mizuno K, Satomora K, Miyamoto A, et al. Angioscopic evaluation of coronary artery thrombi in acute coronary syndromes. N Engl J Med 1992;326:287-291.
    • (1992) N Engl J Med , vol.326 , pp. 287-291
    • Mizuno, K.1    Satomora, K.2    Miyamoto, A.3
  • 10
    • 0032882186 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the ACC/AHA taskforce on practice guidelines
    • Ryan TJ, Antman EM, Brooks NH, et al. ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the ACC/AHA taskforce on practice guidelines. J Am Coll Cardiol 1999;34:890-911.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 890-911
    • Ryan, T.J.1    Antman, E.M.2    Brooks, N.H.3
  • 11
    • 0003226558 scopus 로고
    • Unstable angina: Diagnosis and management
    • Rockville, MD: Agency for Health Care Policy and Research; (AHCPR Publication No. 94-0602).
    • Braunwald E, Mark DB, Jones RH, et al. Unstable angina: Diagnosis and management. Clinical Practice Guideline No. 10. Rockville, MD: Agency for Health Care Policy and Research, 1994. (AHCPR Publication No. 94-0602).
    • (1994) Clinical Practice Guideline No. 10
    • Braunwald, E.1    Mark, D.B.2    Jones, R.H.3
  • 12
    • 0023754429 scopus 로고
    • Aspirin, heparin or both to treat unstable angina
    • Theroux P, Ouimet H, McCans J, et al. Aspirin, heparin or both to treat unstable angina. N Eng J Med 1988;319:1105-1111.
    • (1988) N Eng J Med , vol.319 , pp. 1105-1111
    • Theroux, P.1    Ouimet, H.2    McCans, J.3
  • 13
    • 0027525087 scopus 로고
    • Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina
    • Theroux P, Waters D, Qui S, McCans J, DeGuise P, Juneau M. Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. Circulation 1993;88:2045-2048.
    • (1993) Circulation , vol.88 , pp. 2045-2048
    • Theroux, P.1    Waters, D.2    Qui, S.3    McCans, J.4    Deguise, P.5    Juneau, M.6
  • 14
    • 0025090942 scopus 로고
    • Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease
    • The RISC Group. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 1990;336:827-830.
    • (1990) Lancet , vol.336 , pp. 827-830
  • 15
    • 0028082271 scopus 로고
    • Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in non-prior aspirin users: Primary end points analysis from the ATACS trial
    • Cohen M, Adams PC, Parry G, et al. Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in non-prior aspirin users: Primary end points analysis from the ATACS trial. Circulation 1994;89:81-88.
    • (1994) Circulation , vol.89 , pp. 81-88
    • Cohen, M.1    Adams, P.C.2    Parry, G.3
  • 16
    • 9044243412 scopus 로고    scopus 로고
    • Low-molecular-weight heparin during instability in coronary artery disease
    • Fragmin during Instability in Coronary Artery Disease (FRISC) Study Group. Low-molecular-weight heparin during instability in coronary artery disease. Lancet 1996;347:561-568.
    • (1996) Lancet , vol.347 , pp. 561-568
  • 17
    • 0029771618 scopus 로고    scopus 로고
    • Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina: A meta-analysis
    • Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina: A meta-analysis. JAMA 1996;276:811-815.
    • (1996) JAMA , vol.276 , pp. 811-815
    • Oler, A.1    Whooley, M.A.2    Oler, J.3    Grady, D.4
  • 18
    • 0035369226 scopus 로고    scopus 로고
    • New heparin dosing recommendations for patients with acute coronary syndromes
    • Menon V, Berkowitz SD, Antman EM, Fuchs RM, Hochman JS. New heparin dosing recommendations for patients with acute coronary syndromes. Am J Med 2001;110:641-650.
    • (2001) Am J Med , vol.110 , pp. 641-650
    • Menon, V.1    Berkowitz, S.D.2    Antman, E.M.3    Fuchs, R.M.4    Hochman, J.S.5
  • 19
    • 0035033834 scopus 로고    scopus 로고
    • Lower-dose heparin with fibrinolysis is associated with lower rates of intracranial hemorrhage
    • Giugliano RP, McCabe CH, Antman EM, et al. Lower-dose heparin with fibrinolysis is associated with lower rates of intracranial hemorrhage. Am Heart J 2001;141:742-750.
    • (2001) Am Heart J , vol.141 , pp. 742-750
    • Giugliano, R.P.1    McCabe, C.H.2    Antman, E.M.3
  • 20
    • 0033851626 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with unstable angina, and non-ST-segment activation myocardial infarction. A report of the ACC/AHA taskforce on practice guidelines (Committee of the management of patients with unstable angina)
    • Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina, and non-ST-segment activation myocardial infarction. A report of the ACC/AHA taskforce on practice guidelines (Committee of the management of patients with unstable angina). J Am Coll Cardiol 2000;36:970-1062.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 970-1062
    • Braunwald, E.1    Antman, E.M.2    Beasley, J.W.3
  • 21
    • 0029938993 scopus 로고    scopus 로고
    • Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: The results from the GUSTO-I trial
    • Granger CB, Hirsch J, Califf RM, et al. for the GUSTO-I Trial Investigators. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: The results from the GUSTO-I trial. Circulation 1996;93:870-878.
    • (1996) Circulation , vol.93 , pp. 870-878
    • Granger, C.B.1    Hirsch, J.2    Califf, R.M.3
  • 22
    • 10244242679 scopus 로고    scopus 로고
    • Age and outcome with contemporary thrombolytic therapy: Results from the GUSTO-I trial
    • White HD, Barbash GI, Califf RM, et al. Age and outcome with contemporary thrombolytic therapy: Results from the GUSTO-I trial. Circulation 1996;94:1826-1833.
    • (1996) Circulation , vol.94 , pp. 1826-1833
    • White, H.D.1    Barbash, G.I.2    Califf, R.M.3
  • 24
    • 0029835392 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
    • The GUSTO-IIb Investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996;335:775-782.
    • (1996) N Engl J Med , vol.335 , pp. 775-782
  • 26
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The GUSTO-IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994;90:1631-1637.
    • (1994) Circulation , vol.90 , pp. 1631-1637
  • 27
    • 0026722657 scopus 로고
    • Correlation between level of heparinization and patency of the infarct relate artery treatment of acute myocardial infarction with alteplase (rTPA)
    • Arnout J, Simoons M, DeBono D, Rapold HJ, Collen D, Verstraete M. Correlation between level of heparinization and patency of the infarct relate artery treatment of acute myocardial infarction with alteplase (rTPA). J Am Coll Cardiol 1992;20:513-519.
    • (1992) J Am Coll Cardiol , vol.20 , pp. 513-519
    • Arnout, J.1    Simoons, M.2    DeBono, D.3    Rapold, H.J.4    Collen, D.5    Verstraete, M.6
  • 28
    • 0033815295 scopus 로고    scopus 로고
    • Superiority of enoxaparin versus unfractionated heparin for unstable angina/non-Q-wave myocardial infarction regardless of activated partial thromboplastin time
    • Bozovich GE, Gurfinkel EP, Antman EM, McCabe CH, Mautner B. Superiority of enoxaparin versus unfractionated heparin for unstable angina/non-Q-wave myocardial infarction regardless of activated partial thromboplastin time. Am Heart J 2000;140:637-642.
    • (2000) Am Heart J , vol.140 , pp. 637-642
    • Bozovich, G.E.1    Gurfinkel, E.P.2    Antman, E.M.3    McCabe, C.H.4    Mautner, B.5
  • 29
    • 0032870952 scopus 로고    scopus 로고
    • Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q wave myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 11B trial
    • Antman EM, McCabe CH, Gurfinkel EP, et al. Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q wave myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 11B trial. Circulation 1999;100:1593-1601.
    • (1999) Circulation , vol.100 , pp. 1593-1601
    • Antman, E.M.1    McCabe, C.H.2    Gurfinkel, E.P.3
  • 30
    • 0026647429 scopus 로고
    • Heparin induced prolongation of partial thromboplastin time after thrombolysis: Relation to coronary artery patency
    • Hsia J, Kleiman NS, Aguirre FV, Chaitman BR, Roberts R, Ross AM. Heparin induced prolongation of partial thromboplastin time after thrombolysis: Relation to coronary artery patency. J Am Coll Cardiol 1992;20:31-35.
    • (1992) J Am Coll Cardiol , vol.20 , pp. 31-35
    • Hsia, J.1    Kleiman, N.S.2    Aguirre, F.V.3    Chaitman, B.R.4    Roberts, R.5    Ross, A.M.6
  • 31
    • 0032578548 scopus 로고    scopus 로고
    • Effect of high- and low-molecular-weight heparins on thrombin-thrombomodulin interaction and protein C activation
    • De Cristofaro R, De Candia E, Landolfi R. Effect of high- and low-molecular-weight heparins on thrombin-thrombomodulin interaction and protein C activation. Circulation 1998;98:1297-1301.
    • (1998) Circulation , vol.98 , pp. 1297-1301
    • De Cristofaro, R.1    De Candia, E.2    Landolfi, R.3
  • 32
    • 0029852157 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia
    • Warkentin TE. Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia. Transfus Med Rev 1996 1996;10:249-258.
    • (1996) Transfus Med Rev 1996 , vol.10 , pp. 249-258
    • Warkentin, T.E.1
  • 33
    • 0017335948 scopus 로고
    • Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis
    • Chiu HM, Hirsch J, Yung WL, Regoeczi E, Gent M. Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis. Blood 1977;49:172-184.
    • (1977) Blood , vol.49 , pp. 172-184
    • Chiu, H.M.1    Hirsch, J.2    Yung, W.L.3    Regoeczi, E.4    Gent, M.5
  • 34
    • 0026736119 scopus 로고
    • Reactivation of unstable angina after the discontinuation of heparin
    • Theroux P, Waters D, Lam J, Juneau M, McCans J. Reactivation of unstable angina after the discontinuation of heparin. N Engl J Med 1992;327:141-145.
    • (1992) N Engl J Med , vol.327 , pp. 141-145
    • Theroux, P.1    Waters, D.2    Lam, J.3    Juneau, M.4    McCans, J.5
  • 35
    • 0032952131 scopus 로고    scopus 로고
    • Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration
    • Gori AM, Pepe G, Attanasio M, et al. Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration. Thromb Haemost 1999;81:589-593.
    • (1999) Thromb Haemost , vol.81 , pp. 589-593
    • Gori, A.M.1    Pepe, G.2    Attanasio, M.3
  • 36
    • 0035808013 scopus 로고    scopus 로고
    • Attenuation of rebound ischemia after discontinuation of heparin therapy by glycoprotein IIb/IIIa inhibition with eptifibatide in patients with acute coronary syndromes: Observations from the platelet IIb/IIIa in unstable angina: Receptor suppression using integrilin therapy (PURSUIT) trial
    • Lauer MA, Houghtaling PL, Peterson JG, et al. Attenuation of rebound ischemia after discontinuation of heparin therapy by glycoprotein IIb/IIIa inhibition with eptifibatide in patients with acute coronary syndromes: Observations from the platelet IIb/IIIa in unstable angina: Receptor suppression using integrilin therapy (PURSUIT) trial. Circulation 2001;104:2772-2777.
    • (2001) Circulation , vol.104 , pp. 2772-2777
    • Lauer, M.A.1    Houghtaling, P.L.2    Peterson, J.G.3
  • 37
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The GUSTO-IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994;90:1631-1637.
    • (1994) Circulation , vol.90 , pp. 1631-1637
  • 38
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial
    • Antman EM, Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial. Circulation 1994;90:1624-1630.
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman, E.M.1
  • 39
    • 0034543078 scopus 로고    scopus 로고
    • Intravenous nPA for the treatment of infracting myocardium early: In TIME-II, a double-blind comparison of single bolus lanoteplase vs. accelerated alteplase vs. for the treatment of patients with acute myocardial infarction
    • InTIME-II Investigators. Intravenous nPA for the treatment of infracting myocardium early: In TIME-II, a double-blind comparison of single bolus lanoteplase vs. accelerated alteplase vs. for the treatment of patients with acute myocardial infarction. Eur Heart J 2000;21:2005-2013.
    • (2000) Eur Heart J , vol.21 , pp. 2005-2013
  • 40
    • 0033612881 scopus 로고    scopus 로고
    • Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The ASSENT-2 double-blind randomized trial: Assess of the Safety and Efficacy of a New Thrombolytic Investigators
    • Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The ASSENT-2 double-blind randomized trial: Assess of the Safety and Efficacy of a New Thrombolytic Investigators. Lancet 1999;354:716-722.
    • (1999) Lancet , vol.354 , pp. 716-722
  • 41
    • 0035949117 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction
    • Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction. Lancet 2001;358:605-613.
    • (2001) Lancet , vol.358 , pp. 605-613
  • 42
    • 0035125405 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Sixth ACCP consensus conference on antithrombotic therapy
    • Hirsch J, Warkentin TE, Shaughnessy SG, et al. Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Sixth ACCP consensus conference on antithrombotic therapy. Chest 2001;119:64-93S.
    • (2001) Chest , vol.119
    • Hirsch, J.1    Warkentin, T.E.2    Shaughnessy, S.G.3
  • 43
    • 0030699402 scopus 로고    scopus 로고
    • Effect of weight, sex, age, clinical diagnosis and thromboplastin reagent on steady state intravenous heparin requirements
    • White RH, Zhou H, Woo L, Mungall D. Effect of weight, sex, age, clinical diagnosis and thromboplastin reagent on steady state intravenous heparin requirements. Arch Intern Med 1997;157:2468-2472.
    • (1997) Arch Intern Med , vol.157 , pp. 2468-2472
    • White, R.H.1    Zhou, H.2    Woo, L.3    Mungall, D.4
  • 44
    • 0032800304 scopus 로고    scopus 로고
    • A new regimen for heparin use in acute coronary syndromes
    • Hochman JS, Wali AU, Gavrila D, et al. A new regimen for heparin use in acute coronary syndromes. Am Heart J 1999;138:313-318.
    • (1999) Am Heart J , vol.138 , pp. 313-318
    • Hochman, J.S.1    Wali, A.U.2    Gavrila, D.3
  • 45
    • 0001198665 scopus 로고
    • Improved anticoagulation with a weight adjusted heparin nomogram in patients with acute coronary syndromes: A randomized trial
    • Hassan WM, Flaker GC, Feutz C, Petroski GF, Smith D. Improved anticoagulation with a weight adjusted heparin nomogram in patients with acute coronary syndromes: A randomized trial. J Thromb Thrombol 1995;2:245-249.
    • (1995) J Thromb Thrombol , vol.2 , pp. 245-249
    • Hassan, W.M.1    Flaker, G.C.2    Feutz, C.3    Petroski, G.F.4    Smith, D.5
  • 46
    • 8544279582 scopus 로고    scopus 로고
    • A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery diseases
    • Cohen M, Demers C, Gurfinkel EP, et al., for the ESSENCE study group. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery diseases. N Engl J Med 1997;337:447-452.
    • (1997) N Engl J Med , vol.337 , pp. 447-452
    • Cohen, M.1    Demers, C.2    Gurfinkel, E.P.3
  • 47
    • 0017282426 scopus 로고
    • Heparin kinetics in venous thrombosis and pulmonary embolism
    • Hirsh J, Van Aken WG, Gallus AS, et al. Heparin kinetics in venous thrombosis and pulmonary embolism. Circulation 1976;53:691-695.
    • (1976) Circulation , vol.53 , pp. 691-695
    • Hirsh, J.1    Van Aken, W.G.2    Gallus, A.S.3
  • 48
    • 0027049709 scopus 로고
    • Thrombin-antithrombin III complexes in type II diabetes mellitus
    • Davi G, Gennaro F, Spatola A, et al. Thrombin-antithrombin III complexes in type II diabetes mellitus. J Diabetes Complic 1992;6:7-11.
    • (1992) J Diabetes Complic , vol.6 , pp. 7-11
    • Davi, G.1    Gennaro, F.2    Spatola, A.3
  • 49
    • 0024508350 scopus 로고
    • Increased platelet volume: Sign of impaired thrombopoiesis in diabetes mellitus
    • Tschoepe D, Schauseil S, Rosen P, Kaufman L, Gries FA. Increased platelet volume: Sign of impaired thrombopoiesis in diabetes mellitus. Klin Wochenscht 1989;67:253-259.
    • (1989) Klin Wochenscht , vol.67 , pp. 253-259
    • Tschoepe, D.1    Schauseil, S.2    Rosen, P.3    Kaufman, L.4    Gries, F.A.5
  • 50
    • 0029124112 scopus 로고
    • Unstable angina: A comparison of angioscopic findings between diabetic and non diabetic patients
    • Silva JA, Escobar A, Collins TJ, Ramee SR, White CJ. Unstable angina: A comparison of angioscopic findings between diabetic and non diabetic patients. Circulation 1995;92:1731-1736.
    • (1995) Circulation , vol.92 , pp. 1731-1736
    • Silva, J.A.1    Escobar, A.2    Collins, T.J.3    Ramee, S.R.4    White, C.J.5
  • 51
    • 0029997235 scopus 로고    scopus 로고
    • Relation between systemic anticoagulation as determined by activated partial thromboplastin time and heparin measurements and in-hospital clinical events in unstable angina and non-Q wave myocardial infarction. Thrombolysis in Myocardial Ischemia III B Investigators
    • Becker RC, Cannon CP, Tracy RP, et al. Relation between systemic anticoagulation as determined by activated partial thromboplastin time and heparin measurements and in-hospital clinical events in unstable angina and non-Q wave myocardial infarction. Thrombolysis in Myocardial Ischemia III B Investigators. Am Heart J 1996;131:421-433.
    • (1996) Am Heart J , vol.131 , pp. 421-433
    • Becker, R.C.1    Cannon, C.P.2    Tracy, R.P.3


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