Attenuation of rebound ischemia after discontinuation of heparin therapy by glycoprotein IIb/IIIa inhibition with eptifibatide in patients with acute coronary syndromes obesrvations from the platelet IIb/IIIa in unstable agina: Receptor suppression using integrilin therapy (PURSUIT) trail

Circulation

Volumn 104, Issue 23, 2001, Pages 2772-2777

  Lauer, Michael A ^a   Houghtaling, Penny L ^b   Peterson, John G ^b   Granger, Christopher B ^d   Bhatt, Deepak L ^b   Sapp, Shelly K ^b   Simoons, Maarten L ^c   Harrington, Robert A ^d   Topol, Eric J ^b   Lincoff, A Michael ^b  

^a Borgess Research Institute   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Glycoproteins; Heparin; Ischemia; Mortality; Platelets

Indexed keywords

EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART REINFARCTION; HEPARINIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; NORTH AMERICA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REBOUND; REGRESSION ANALYSIS; TREATMENT OUTCOME; UNSTABLE ANGINA PECTORIS;

EID: 0035808013     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4801.100358     Document Type: Article

References (12)

1. Reactivation of unstable angina after the discontinuation of heparin
2. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: Results from the GUSTO-I trial
3. Low molecular weight heparin decreases rebound ischemia in unstable angina or non-Q-wave myocardial infarction: The Canadian ESSENCE ST segment monitoring substudy
4. Reactivation of ischemic events in acute coronary syndromes: Results from GUSTO-IIb: Global Use of Strategies To Open occluded arteries in acute coronary syndromes
5. Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes
6. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor
7. The effect of hirudin versus heparin on hemostatic activity in patients with acute coronary syndromes: The GUSTO IIb Hemostasis Substudy
8. Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes
9. Evidence for a rebound coagulation phenomenon after cessation of a 4-hour infusion of a specific thrombin inhibitor in patients with unstable angina pectoris
10. Randomized double-blind comparison of two doses of Hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction
11. Geographic variability in outcomes within an international trial of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes: Results from PURSUIT
12. Variations in patient management and outcomes for acute myocardial infarction in the United States and other countries: Results from the GUSTO trial: Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries