Establishment and functional validation of a structural homology model for human DNA methyltransferase 1

Biochemical and Biophysical Research Communications

Volumn 306, Issue 2, 2003, Pages 558-563

  Siedlecki, Pawel ^a,b   Garcia Boy, Regine ^b   Comagic, Slobodan ^c   Schirrmacher, Ralf ^c   Wiessler, Manfred ^b   Zielenkiewicz, Piotr ^a   Suhai, Sandor ^b   Lyko, Frank ^b  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

5 Azacytidine; DNA methylation; DNA methyltransferase; DNMT1; Homolgy modeling; Inhibitor; Three dimensional structure

Indexed keywords

AZACITIDINE; DNA METHYLTRANSFERASE;

ARTICLE; BIOAVAILABILITY; CANCER CHEMOTHERAPY; CATALYSIS; CATALYST; CONTROLLED STUDY; DNA METHYLATION; DNA STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; TUMOR CELL LINE; VALIDATION PROCESS;

EID: 0038546417     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01000-3     Document Type: Article

References (29)

1. Bird A. Genes Dev. 16:2002;6-21.
2. Robertson K.D., Wolffe A.P. Nat. Rev. Genet. 1:2000;11-19.
3. Jones P.A., Baylin S.B. Nat. Rev. Genet. 3:2002;415-428.
4. Baylin S.B., Herman J.G. Trends Genet. 16:2000;168-174.
5. Bestor T.H. Hum. Mol. Genet. 9:2000;2395-2402.
6. Okano M., Xie S., Li E. Nat. Genet. 19:1998;219-220.
7. Okano M., Bell D.W., Haber D.A., Li E. Cell. 99:1999;247-257.
8. Gruenbaum Y., Cedar H., Razin A. Nature. 295:1982;620-622.
9. Bestor T.H., Ingram V.M. Proc. Natl. Acad. Sci. USA. 80:1983;5559-5563.
10. Leonhardt H., Page A.W., Weier H.U., Bestor T.H. Cell. 71:1992;865-873.
11. Chuang L.S., Ian H.I., Koh T.W., Ng H.H., Xu G., Li B.F. Science. 277:1997;1996-2000.
12. Li E., Bestor T.H., Jaenisch R. Cell. 69:1992;915-926.
13. Robert M.F., Morin S., Beaulieu N., Gauthier F., Chute I.C., Barsalou A., MacLeod A.R. Nat. Genet. 33:2003;61-65.
14. Santi D.V., Norment A., Garrett C.E. Proc. Natl. Acad. Sci. USA. 81:1984;6993-6997.
15. Klimasauskas S., Kumar S., Roberts R.J., Cheng X. Cell. 76:1994;357-369.
16. Reinisch K.M., Chen L., Verdine G.L., Lipscomb W.N. Cell. 82:1995;143-153.
17. Dong A., Yoder J.A., Zhang X., Zhou L., Bestor T.H., Cheng X. Nucleic Acids Res. 29:2001;439-448.
18. Kumar S., Cheng X., Klimasauskas S., Mi S., Posfai J., Roberts R.J., Wilson G.G. Nucleic Acids Res. 22:1994;1-10.
19. Liu K., Wang Y.F., Cantemir C., Muller M.T. Mol. Cell. Biol. 23:2003;2709-2719.
20. R.A. Laskowski, M.W. MacArthur, D.S. Moss, J.M. Thornton, J. Appl. Cryst. 26 (1993) 283-291.
21. Aparicio A., Weber J.S. Curr. Opin. Investig. Drugs. 3:2002;627-633.
22. Christman J.K. Oncogene. 21:2002;5483-5495.
23. Saunders B.C., Stacey G.J. J. Chem. Soc. 1948;1773-1779.
24. Stach D., Schmitz O.J., Stilgenbauer S., Benner A., Dohner H., Wiessler M., Lyko F. Nucleic Acids Res. 31:2003;e2.
25. Thompson J.D., Higgins D.G., Gibson T.J. Nucleic Acids Res. 22:1994;4673-4680.
26. Oshiro C.M., Kuntz I.D. J. Comput. Aided Mol. Des. 9:1995;113-130.
27. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., Olson A.J. J. Comput. Chem. 19:1998;1639-1662.
28. Hurwitz R., Hozier J., LeBien T., Minowada J., Gajl-Peczalska K., Kubonishi I., Kersey J. Int. J. Cancer. 23:1979;174-180.
29. Granzow C., Drings P., Kopun M. Drings P., Vogt-Moykopf I. Thoraxtumoren. Diagnostik - Staging - gegenwärtiges Therapiekonzept. 1998;327-332 Springer, Berlin.