A direct comparison of the mixing efficiency in solid-phase organic synthesis by single bead IR and fluorescence spectroscopy

Tetrahedron Letters

Volumn 38, Issue 37, 1997, Pages 6485-6488

  Li, Wenbao ^a   Yan, Bing ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HYDRAZINE DERIVATIVE; POLYSTYRENE DERIVATIVE; RESIN;

ARTICLE; FLUORESCENCE SPECTROSCOPY; INFRARED SPECTROSCOPY; SYNTHESIS; TECHNIQUE;

EID: 0030767556     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01493-7     Document Type: Article

References (20)

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19. In all experiments, formylpolystyrene resin (NovaBiochem., 1% DVB, 100-200 mesh) was used. Dansylhydrazine was purchased from Aldrich. The formylpolystyrene resin was shaked with DMF for 30 min before reactions. All reactions were performed in DMF at room temperature. The dansylhydrazine concentration was 60 mM in all cases and the excess was always two fold except where noted.
20. Bing Yan; Wenbao Li, Rapid fluorescence determination of the absolute amount of aldehyde groups on resin support, submitted.