Single-bead analysis in combinatorial chemistry

Current Opinion in Chemical Biology

Volumn 6, Issue 3, 2002, Pages 328-332

  Yan, Bing ^a  

^a Discovery Partners International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RESIN;

ANALYTIC METHOD; COMBINATORIAL CHEMISTRY; DIFFUSION; REVIEW; SCREENING; SYNTHESIS;

EID: 0036603596     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(02)00325-3     Document Type: Review

References (43)

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2. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
3. General method for rapid synthesis of multicomponent peptide mixtures
4. Analytical techniques for single bead analysis in combinatorial chemistry
5. Characterization of a split-pool combinatorial library
6. The role of the support in solid phase peptide synthesis
7. Determination of functional group distribution within Rasta resins utilizing optical analysis
8. Visualization functional group distribution in solid-support beads by using optical analysis
9. Spatially resolved single bead analysis: Homogeneity, diffusion, and adsorption in cross-linked polystyrene
10. Single-bead fluorescence microspectroscopy: Detection of self-quenching in fluorescence-labeled resin beads
11. Site distribution in resin beads as determined by confocal Raman spectroscopy
12. Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy
13. Diffusion of reagents in macrobeads
14. Monitoring the progress and the yield of solid phase organic reactions directly on resin supports
15. Kinetic comparison of trifluoroacetic acid cleavage reactions of resin-bound carbamates, ureas, secondary amides, and sulfonamides from benzyl-, benzhydryl-, and indole-based linkers
16. Combination of single FTIR and chemometrics in combinatorial chemistry: Application of the multivariate calibration monitoring solid-phase organic synthesis
17. On-bead quantitation of resin bound functional groups using analogue techniques with vibrational spectroscopy
18. Chemically sensitive high throughput parallel analysis of solid phase supported library members
19. FT-IR mapping - A new tool for spatially resolved characterization of polymer-bound combinatorial compound libraries with IR microscopy
20. Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography
21. Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions
22. Single-bead characterization using analytical constructs: Application to quality control of libraries
23. Analysis of single polymer beads for solid phase combinatorial synthesis: The determination of reactive thiol and within batch polydispersity of bead loadings
24. A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags. Development and application of tag decode-assisted single bead LC/MS analysis
25. Compaison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase
26. Combinatorial approaches to heterogeneous catalysis: Strategies for academic research
27. On-bead combinatorial approach to the design of chiral stationary phases for HPLC
28. Small-molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides
29. Printing small molecules as microarrays and detecting protein-ligand interactions en masse
30. Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries
31. Single bead and hard tag decoding using accurate isotopic difference target analysis-encoded combinatorial libraries
32. Encoding of combinatorial chemistry libraries by fluorine-19 NMR
33. Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries
34. Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry
35. Nonpeptidic AvB3 integrin antagonist libraries on-bead screening and mass spectrometric identification without tagging
36. Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by nanoprobe MAS-NMR spectroscopy
37. Comprehensive survey of combinatorial library synthesis: 1999
38. Comprehensive survey of combinatorial library synthesis: 2000
39. High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface
40. Combinatorial screening of homogeneous catalysis and reaction optimization based on multiplexed capillary electrophoresis
41. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling
42. Decoding products of diversity pathways from stock solutions derived from single poltmeric macrobeads
43. 1H NMR characterization of the product from single solid-phase resin beads using capillary NMR flow probes