Compensating for the meltdown: The critical effective size of a population with deleterious and compensatory mutations

Annales Zoologici Fennici

Volumn 40, Issue 2, 2003, Pages 169-183

  Whitlock, Michael C ^a   Griswold, Cortland K ^a   Peters, Andrew D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EFFECTIVE POPULATION SIZE; EXTINCTION; MUTATION; PERSISTENCE; POPULATION GENETICS;

EID: 0038526273     PISSN: 0003455X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (57)

1. Akashi, H. 1995: Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA. - Genetics 139: 1067-1076.
2. Burch, C. L. & Chao, L. 1999: Evolution by small steps and rugged landscapes in the RNA virus φ6. - Genetics 151: 921-927.
3. Charlesworth, D., Morgan, M. T. & Charlesworth, B. 1993: Mutation accumulation in finite outbreeding and inbreeding populations. - Genet. Res. 61: 39-56.
4. Cowen, L. E., Kohn, L. M. & Anderson, J. B. 2001: Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans. - J. Bact. 183: 2971-2978.
5. Crill, W. D., Wichman, H. A. & Bull, J. J. 2000: Evolutionary reversals during viral adaptation to alternating hosts. - Genetics 154: 27-37.
6. Crow, J. F. 1948: Alternative hypotheses of hybrid vigor. - Genetics 33: 477-487.
7. Estes, S. & Lynch, M. 2003: Rapid recovery in mutationally degraded lines of Caenorhabditis elegans. - Evolution. [In press].
8. Fares, M. A., Ruiz, M. X., Moya-González, A., Elena, S. F. & Barrio, E. 2002: GroEL buffers against deleterious mutations. - Nature 417: 398.
9. Fisher, R. A. 1930: Genetical theory of natural selection. - The Clarendon Press, Oxford.
10. Frankham, R. 1995: Effective population size/adult population size ratios in wildlife: a review. - Genet. Res. 66: 95-107.
11. Fukami-Kobayashi, K., Schreiber, D. R. & Benner, S. A. 2002: Detecting compensatory covariation signals in protein evolution using reconstructed ancestral sequences. - J. Mol. Bio. 319: 729-743.
12. Hancock, J. M., Shaw, P. J., Bonneton, F. & Dover, G. A. 1999: High sequence turnover in the regulatory regions of the developmental gene hunchback in insects. - Mol. Biol. Evol. 16: 253-265.
13. Hartl, D. L. & Taubes, C. H. 1996: Compensatory nearly neutral mutations: Selection without adaptation. - J. theor. Biol. 182: 303-309.
14. Hartl, D. L. & Taubes, C. H. 1998: Towards a theory of evolutionaryadaptation. - Genetica 102/103: 525-533.
15. Holder, K. K. & Bull, J. J. 2001: Profiles of adaptation in two similar viruses. - Genetics 159: 1393-1404.
16. Kacser, H. & Burns, J. A. 1973: The control of flux. - Syrup. Soc. Exp. Biol. 32: 65-104.
17. Kacser, H. & Burns, J. A. 1981: The molecular basis of dominance. - Genetics 97: 639-666.
18. Kimura, M. 1957: Some problems of stochastic processes in genetics. - Ann. Math. Stat. 28: 882-901.
19. Kimura, M., Maruyama, T. & Ohta, T. 1963: The mutation load in small populations. - Genetics 48: 1303-1312.
20. Kliman, R. M., Andolfatto, P., Coyne, J. A., Depaulis, F., Kreitman, M., Berry, A. J., McCarter, J., Wakeley, J. & Hey, J. 2000: The population genetics of the origin and divergence of the Drosophila simulans complex species. - Genetics 156: 1913-1931.
21. Krakauer, D. C. & Plotkin, J. B. 2002: Redundancy, antiredundancy and the robustness of genomes. - Proc. Natl. Acad. Sci. USA 99: 1405-1409.
22. Lande, R. 1994: Risk of population extinction from fixation of new deleterious mutations. - Evolution 48: 1460-1469.
23. Lande, R. 1995: Mutation and conservation. - Cons. Biol. 9: 782-791.
24. Lande, R. 1998: Risk of population extinction from fixation of deleterious and reverse mutations. - Genetica: 102/103: 21-27.
25. Lenski, R. E., Rose, M. R., Simpson, S. C. & Tadler, S. C. 1991: Long-term experimental evolution in Escherichia coli. I. Adaptation and divergence during 2000 generations. - Am. Nat. 138: 1315-1341.
26. Levin, B. R., Perrot, V. & Walker, N. 2000: Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. - Genetics 154: 985-997.
27. Ludwig, M. Z., Bergman, C., Patel, N. H. & Kreitman, M. 2000: Evidence for stabilizing selection in a eukaryotic enhancer element. - Nature 403: 564-567.
28. Ludwig, M. Z., Patel, N. H. & Kreitman, M. 1998: Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. - Development 125: 949-958.
29. Lynch, M. & Gabriel, W. 1990: Mutation load and survival of small populations. - Evolution 44: 1725-1737.
30. Lynch, M. & Walsh, B. 1998: Genetics and analysis of quantitative traits. - Sunderland, MA, Sinauer.
31. Lynch, M., Conery, J. & Bürger, R. 1995a: Mutational meltdown in sexual populations. - Evolution 49: 1067-1080.
32. Lynch, M., Conery, J. & Bürger, R. 1995b: Mutation accumulation and the extinction of small populations. - Am. Nat. 146: 489-518.
33. Lynch, M., Bürger, R., Butcher, D. & Gabriel, W. 1993: The mutational meltdown in asexual populations. - J. Heredity 84: 339-344.
34. Lynch, M., Blanchard, J., Houle, D., Kibota, T., Schultz, S., Vassilieva, L. & Willis, J. H. 1999: Perspective: Spontaneous deleterious mutation. - Evolution 53: 645-663.
35. McDonald, J. H. & Kreitman, M. 1991: Adaptive evolution at the Adh locus in Drosophila. - Nature 351: 652-654.
36. Moore, F. B. G., Rozen, D. E. & Lenski, R. E. 2000: Pervasive compensatory adaptation in Escherichia coli. - Proc. R. Soc. Lond. B 267: 515-522.
37. Moriyama, E. N. & Powell, J. R. 1997: Codon usage bias and tRNA abundance in Drosophila. - J. Mol. Evol. 45: 514-523.
38. Orr, H. A. & Coyne, J. A. 1992: The genetics of adaptation - a reassessment. - Am. Nat. 140: 725-742.
39. Parsch, J., Braverman, J. M. & Stephan, W. 2000: Comparative sequence analysis and pattens of covariation in RNA secondary structures. - Genetics 154: 909-921.
40. Parsch, J., Tanda, S. & Stephan, W. 1997: Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster. - Proc. Natl. Acad. Sci. USA 94: 928-933.
41. Peixoto, A., Hennessy, J. M., Townson, I., Hassan, G., Rosbash, M., Costa, R. & Kyriacou, C. P. 1998: Molecular coevolution within a Drosophila clock gene. - Proc. Natl. Acad. Sci. USA 95: 4475-4480.
42. Phillips, P. C., Otto, S. P. & Whitlock, M. C. 2000: Beyond the average: The evolutionary importance of epistasis and the variability of epistatic effects. - In: Wolf, J., Brodie, E. D. III & Wade, M. J. (eds.), Epistusis and the evolutionary process: 20-38. Oxford University Press, Oxford.
43. Poon, A. & Otto, S. P. 2000: Compensating for our load of mutations: Freezing the meltdown of small populations. - Evolution 54: 1467-1479.
44. Prelich, G. 1999: Suppression mechanisms: Themes from variations. - Trends Genet. 15: 261-266.
45. Queitsch, C., Sangster, T. A. & Lindquist, S. 2002: Hsp90 as a capacitor of phenotypic variation. - Nature 417: 618-624.
46. Reynolds, M. G. 2000: Compensatory evolution in rifampin-resistant Escherichia coli. - Genetics 156: 1471-1481.
47. Rokyta, D., Badgett, M. R., Molineux, I. J. & Bull, J. J. 2002: Experimental genomic evolution: Extensive compensation for a loss of DNA activity in a virus. - Mol. Bio. Evol. 19: 230-238.
48. Rutherford, S. L. & Lindquist, S. 1998: Hsp90 as a capacitor for morphological evolution. - Nature 396: 336-342.
49. Schrag, S. J. & Perrot, V. 1996: Reducing antibiotic resistance. - Nature 381: 120-121.
50. Schrag, S. J., Perrot, V. & Levin, B. R. 1997: Adaptation to the fitness costs of antibiotic resistance in Escherichia coli. - Proc. R. Soc. Lond. B 264: 1287-1291.
51. Schultz, S. T. & Lynch, M. 1997: Mutation and extinction: The role of variable mutational effects, synergistic epistasis, beneficial mutations, and degree of outcrossing. - Evolution 51: 1363-1371.
52. Shuman, H. A. & Beckwith, J. 1979: Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactosidase transport system. - J. Bacteriol. 137: 365-373.
53. Smith, N. G. C. & Eyre-Walker, A. 2002: Adaptive protein evolution in Drosophila. - Nature 415: 1022-1024.
54. Whitlock, M. C. 2000: Fixation of new alleles and the extinction of small populations: Drift load, beneficial alleles, and sexual selection. - Evolution 54: 1855-1861.
55. Whitlock, M. C. & Otto, S. P. 1999: The panda and the phage: Compensatory mutations and the persistence of small populations. - Trends Evol. Ecol. 14: 293-294.
56. Wright, S. 1931: Evolution in Mendelian populations. - Genetics 16: 97-159.
57. Zeyl, C., Mizesko, M. & de Visser, J. A. G. M. 2001: Mutational meltdown in laboratory yeast populations. - Evolution 55: 909-917.