Glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 284, Issue 6 53-6, 2003, Pages

  Schick, Rafael R ^a   Zimmermann, Jens P ^b   Vorm Walde, Thomas ^b   Schusdziarra, Volker ^b  

^a BUNDESWEHRKRANKENHAUS ULM   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Amygdala; Dorsomedial hypothalamus; Exendin (9 39) amide; Feeding behavior; Glucagon like peptide 1; Hypothalamus; Lateral hypothalamus; Rats; Ventromedial hypothalamus

Indexed keywords

EXENDIN[9-39] AMIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; HORMONE ANTAGONIST; UNCLASSIFIED DRUG; EXENDIN (9 39) AMIDE; EXENDIN (9-39) AMIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1 (7 36); GLUCAGON-LIKE PEPTIDE 1 (7-36); PEPTIDE FRAGMENT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; HYPOTHALAMUS; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY; THALAMUS MIDLINE NUCLEUS; ZONA INCERTA; ANIMAL; DOSE RESPONSE; DRUG EFFECT; TIME; WISTAR RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMUS, MIDDLE; MALE; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0038520993     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00479.2002     Document Type: Article

References (54)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. Baggio L, Adatia F, Bock T, Brubaker PL, and Drucker DJ. Sustained expression of exendin-4 does not perturb glucose homeostasis, β-cell mass, or food intake in metallothionein preproexendin transgenic mice. J Biol Chem 275: 34471-34477, 2000.
3. Box BM and Mogenson GJ. Alterations in ingestive behaviors after bilateral lesions of the amygdala in the rat. Physiol Behav 15: 679-688, 1975.
4. Brownlee KA. Statistical Theory and Methodology in Science and Engineering. New York: Wiley, 1965.
5. Calvo JC, Yusta B, Mora F, and Blázquez E. Structural characterization by affinity cross-linking of glucagon-like peptide-1 (7-36) amide receptor in rat brain. J Neurochem 64: 299-306, 1995.
6. Choi YH and Anderson H. An interaction between hypothalamic glucagon-like peptide-1 and macronutrient composition determines food intake in rats. J Nutr 131: 1819-1825, 2001.
7. Donahey JCK, van Dijk G, Woods SC, and Seeley RJ. Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats. Brain Res 779: 75-83, 1998.
8. Drucker DJ and Asa S. Glucagon gene expression in vertebrate brain. J Biol Chem 263: 13475-13478, 1988.
9. Fonberg E. The role of the hypothalamus and amygdala in food intake, alimentary motivation and emotional reactions. Acta Biol Exp 29: 335-358, 1969.
10. Ghiglione M, Uttenthal LO, George SK, and Bloom SR. How glucagon-like is glucagon-like peptide-1? Diabetologia 27: 599-600, 1984.
11. Göke R, Larsen PJ, Mikkelsen JD, and Sheikh SP. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 7: 2294-2300, 1995.
12. Grossman SP. Role of the hypothalamus in the regulation of food and water intake. Psychol Rev 82: 200-224, 1975.
13. Hollopeter G, Erickson JC, Seeley RJ, Marsh DJ, and Palmiter RD. Response of neuropeptide Y-deficient mice to feeding effectors. Regul Pept 75-76: 383-389, 1998.
14. Hoosein NM and Gurd RS. Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase. FEBS Lett 178: 83-86, 1984.
15. Jin SLC, Han VKM, Simmons JE, Towle AC, Lander JM, and Lund PK. Distribution of glucagon-like peptide 1 (GLP-1), glucagons, and glicentin in the rat brain: an immunocytochemical study. J Comp Neurol 271: 519-532, 1988.
16. Kanse SM, Kreymann B, Ghatei MA, and Bloom SR. Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung. FEBS Lett 241: 209-212, 1988.
17. Kasting NW. Criteria for establishing a physiological role for brain peptides. A case in point: the role of vasopressin in thermoregulation during fever and antipyresis. Brain Res Rev 14: 143-153, 1989.
18. Kim MS, Jo YH, Yoon SH, Hahn SJ, Rhie DJ, Kim CC, and Choi H. Electrical stimulation of the medial amygdala facilitates gastric acid secretion in conscious rats. Brain Res 524: 208-212, 1990.
19. Kreymann B, Ghatei MA, Burnet P, Williams G, Kanse S, Diani AR, and Bloom SR. Characterization of glucagon-like peptide-1-(7-36) amide in the hypothalamus. Brain Res 502: 325-331, 1989.
20. Kreymann B, Williams G, Ghatei MA, and Bloom SR. Glucagon-like peptide-1 (7-36): a physiological incretin in man. Lancet 2: 1300-1304, 1987.
21. Kupfermann I. Hypothalamus and limbic system I: peptidergic neurons, homeostasis and emotional behavior. In: Principles of Neural Science (2nd ed.), edited by Kandel ER and Schwartz JH. New York: Elsevier, 1985, chapt 46, p. 614.
22. 2 in the central control of feeding behavior. Digestion 54: 360-361, 1993.
23. Larsen PJ, Tang-Christensen M, Holst JJ, and Orskov C. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 77: 257-270, 1997.
24. Luiten PG, ter Horst GJ, and Steffens AB. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog Neurobiol 28: 1-54, 1987.
25. McMahon LR and Wellman PJ. Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide. Pharmacol Biochem Behav 58: 673-677, 1997.
26. McMahon LR and Wellman PJ. PVN infusion of GLP-1-(736) amide suppresses feeding but does not induce aversion or alter locomotion in rats. Am J Physiol Regul Integr Comp Physiol 274: R23-R29, 1998.
27. Meeran K, O'Shea D, Mark C, Edwards B, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ, Goldstone AP, Taylor GM, Sunter D, Steere J, Choi SJ, Ghatei MA, and Bloom SR. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-46) amide or exendin-(939) alters body weight in the rat. Endocrinology 140: 244-250, 1999.
28. Mine K, Tsuruta N, Nakai Y, Kataoka Y, Fujiwara M, Ueki S, and Nakagawa T. Effects of small amygdaloid lesions on pancreatic exocrine secretion. Brain Res 340: 9-18, 1985.
29. Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, and Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261: 11880-11889, 1986.
30. Morley JE. Neuropeptide regulation of appetite and weight. Endocr Rev 8: 256-287, 1987.
31. Orskov C. Glucagon-like peptide 1, a new hormone of the enteroinsular axis. Diabetologia 35: 701-711, 1992.
32. Pellegrino LJ, Pellegrino AS, and Cushman AJ. A Stereotaxic Atlas of the Rat Brain. New York: Plenum, 1979.
33. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, and Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138: 351-355, 1997.
34. Schick RR, Harty GJ, Yaksh TL, and Go VLW. Sites in the brain at which cholecystokinin octapeptide (CCK-8) acts to suppress feeding in rats: a mapping study. Neuropharmacology 29: 109-118, 1990.
35. Schick RR, Samsami S, Zimmermann JP, Eberl T, Endres C, Schusdziarra V, and Classen M. Effect of galanin on food intake in rats: involvement of lateral and ventromedial hypothalamic sites. Am J Physiol Regul Integr Comp Physiol 264: R355-R361, 1993.
36. Schick RR, Schusdziarra V, Endres C, Eberl T, and Classen M. Putative sleep factors and satiety in rats: role of cholecystokinin (CCK) and delta sleep inducing peptide (DSIP). Neuropeptides (Life Sci Adv) 10: 41-48, 1991.
37. Schick RR, Schusdziarra V, Nussbaumer C, and Classen M. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain Res 552: 232-239, 1991.
38. Schick RR, Schusdziarra V, Yaksh TL, and Go VLW. Brain regions where cholecystokinin exerts its effect on satiety. Ann NY Acad Sci 713: 242-254, 1994.
39. Schick RR, Yaksh TL, and Go VLW. An intragastric meal releases the putative satiety factor cholecystokinin from hypothalamic neurons in cats. Brain Res 370: 349-353, 1986.
40. Schick RR, Yaksh TL, Roddy DR, and Go VLW. Release of hypothalamic cholecystokinin in cats: effects of nutrient and volume loading. Am J Physiol Regul Integr Comp Physiol 256: R248-R254, 1989.
41. Schick RR, Zimmermann JP, vorm Walde T, Schusdziarra V, and Classen M. Glucagon-like peptide (GLP)-1 (7-36) amide: a central suppressor of food intake in fasted rats (Abstract). Gastroenterology 102: A750, 1992.
42. Schoenfeld TA and Hamilton LW. Disruption of appetite but not hunger or satiety following small lesions in the amygdala of the rat. J Comp Physiol Psychol 95: 565-587, 1981.
43. Scrocchi LA, Brown TJ, MacLusky N, Brubaker PL, Auerbach AB, Joyner AL, and Drucker DJ. Glucose intolerance but normal satiety in mice with a null mutation in the glucagonlike peptide receptor gene. Nat Med 2: 1254-1258, 1996.
44. -/- mice. Endocrinology 139: 3127-3132, 1998.
45. Scrocchi LA, Hill ME, Saleh J, Perkins B, and Drucker DJ. Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action. Diabetes 49: 1552-1560, 2000.
46. Shimizu I, Hirota M, Ohboshi C, and Shima K. Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 121: 1076-1082, 1987.
47. Suda K, Takahashi H, Fukase N, Manaka H, Tominaga M, and Sasaki H. Distribution and molecular forms of glucagon-like peptide in the dog. Life Sci 45: 1793-1798, 1989.
48. Tang-Christensen M, Larsen PJ, Göke R, Fink-Jensen A, Jessop DS, Moller M, and Sheikh SP. Central administration of GLP-1 (7-36) amide inhibits food and water intake in rats. Am J Physiol Regul Integr Comp Physiol 271: R848-R856, 1996.
49. Thiele TE, van Dijk G, Campfield LA, Smith FJ, Burn P, Woods SC, Bernstein IL, and Seeley RJ. Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats. Am J Physiol Regul Integr Comp Physiol 272: R726-R730, 1997.
50. 2 in the paraventricular nucleus of the hypothalamus increases feeding. J Endocrinology 148, Suppl: P126, 1996.
51. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J, and Bloom SR. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72, 1996.
52. Uttenthal O, Toledano A, and Blázquez E. Autoradiographic localization of receptors for glucagon-like peptide-1 (7-36) amide in rat brain. Neuropeptides 21: 143-146, 1992.
53. Wang T, Edwards GL, and Baile CA. Glucagon-like peptide-1 (7-36) amide administered into the third cerebroventricle inhibits water intake in rats. Proc Soc Exp Biol Med 219: 85-91, 1998.
54. Yoshimoto S, Hirota M, Ohboshi C, and Shima K. Identification of glucagon-like peptide-1(7-36)amide in rat brain. Ann Clin Biochem 26: 169-171, 1989.