Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts

Blood

Volumn 101, Issue 10, 2003, Pages 4115-4121

  Klein, Ulf ^b   Gloghini, Annunziata ^b   Gaidano, Gianluca ^b   Chadburn, Amy ^b   Cesarman, Ethel ^b   Dalla Favera, Riccardo ^b   Carbone, Antonino ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; B LYMPHOCYTE; BLAST TRANSFORMATION; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GERMINAL CENTER; HUMAN; HUMAN CELL; HYBRIDIZATION; IMMUNOBLAST; IMMUNOBLASTIC LYMPHOMA; IMMUNOCOMPETENCE; IMMUNOHISTOLOGY; LYMPHOBLASTOID CELL; MEMORY CELL; NONHODGKIN LYMPHOMA; PHENOTYPE; PLASMA CELL; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; STATISTICAL ANALYSIS; CLASSIFICATION; COMPARATIVE STUDY; GENE EXPRESSION PROFILING; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPHOMA; METHODOLOGY; PATHOLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; B-LYMPHOCYTES; GENE EXPRESSION PROFILING; HIV INFECTIONS; HUMANS; LYMPHOMA; LYMPHOMA, NON-HODGKIN; PHENOTYPE; TRANSCRIPTION, GENETIC;

EID: 0038495928     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-10-3090     Document Type: Article

References (43)

1. Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumors, Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.
2. Gaidano G, Carbone A. Primary effusion lymphoma: a liquid phase lymphoma of fluid-filled body cavities. Adv Cancer Res. 2001;80:115-146.
3. Cesarman E, Knowles DM. The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases. Semin Cancer Biol. 1999;9:165-174.
4. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995;332:1186-1191.
5. Horenstein MG, Nador RG, Chadburn A, et al. Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. Blood. 1997;90:1186-1191.
6. Matolcsy A, Nador RG, Cesarman E, Knowles DM, Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. Am J Pathol. 1998;153:1609-1614.
7. Fais F, Gaidano G, Capello D, et al. Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas. Leukemia. 1999;13:1093-1099.
8. Rajewsky K. Clonal selection and learning in the antibody system. Nature. 1996;381:751-758.
9. Gaidano G, Capello D, Cilia AM, et al. Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: implications for disease pathogenesis and histogenesis. Genes Chromosomes Cancer. 1999;24:16-23.
10. Gaidano G, GloghiniA, Gattei V, et al. Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood. 1997;90:4894-4900.
11. Carbone A, Gaidano G. HHV-8-positive body-cavity-based lymphoma: a novel lymphoma entity. Br J Haematol. 1997;97:515-522.
12. Carbone A, Gloghini A, Larocca LM, et al. Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas. Blood. 2001;97:744-751.
13. Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194:1625-1638.
14. Califano A, Stolovitzky G, Tu Y. Analysis of gene expression microarrays for phenotype classification. Proc Int Conf Intell Syst Mol Biol. 2000;8:75-85.
15. Carbone A, Gloghini A, Bontempo D, et al. Proliferation in HHV-8-positive primary effusion lymphomas is associated with expression of HHV-8 cyclin but independent of p27(kip1). Am J Pathol. 2000;156:1209-1215.
16. Hsu SM, Raine L, Fanger H. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol. 1981;75:734-738.
17. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A. 1998;95:14863-14868.
18. Hartigan JA. Clustering Algorithms. New York, NY: Wiley; 1975.
19. Rowe M, Rowe DT, Gregory CD, et al. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J. 1987;6:2743-2751.
20. Young LS, Rowe M. Epstein-Barr virus, lymphomas and Hodgkin's disease. Semin Cancer Biol. 1992;3:273-284.
21. Calame KL. Plasma cells: finding new light at the end of B cell development. Nat Immunol. 2001;2:1103-1108.
22. Morrison AM, Nutt SL, Thevenin C, Rolink A, Busslinger M. Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation. Semin Immunol. 1998;10:133-142.
23. Carbone A, Gloghini A, Cozzi MR, et al. Expression of MUM1/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis. Br J Haematol. 2000;111:247-257.
24. Asou H, Said JW, Yang R, et al. Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. Blood. 1998;91:2475-2481.
25. Aoki Y, Tosato G. Role of vascular endothelial growth factor/vascular permeability factor in the pathogenesis of Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphomas. Blood. 1999;94:4247-4254.
26. McEver RP, Cummings RD. Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997;100:485-491.
27. Moore KL. Structure and function of P-selectin glycoprotein ligand-1. Leuk Lymphoma. 1998;29:1-15.
28. Underhill GH, Minges-Wols HA, Fornek JL, Witte PL, Kansas GS. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood. 2002;99:2905-2912.
29. Apostolopoulos V, McKenzie IF. Cellular mucins: targets for immunotherapy. Crit Rev Immunol. 1996;14:293-309.
30. Consolini R, Pala S, Legitimo A, Crimaldi G, Ferrari S. Effects of vitamin D on the growth of normal and malignant B-cell progenitors. Clin Exp Immunol. 2001;126:214-219.
31. Nelson BH, Willerford DM. Biology of the interleukin-2 receptor. Adv Immunol. 1998;70:1-81.
32. Klein U, Stolovitzky G, Keller JL, et al. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci U S A. 2003;100:2639-2644.
33. Jaffe ES. Primary body cavity-based AIDS-related lymphomas. Evolution of a new disease entity. Am J Clin Pathol. 1996;105:141-143.
34. Fan W, Bubman D, Chadburn A, Cesarman E, Knowles DM. Distinct subsets of PEL can be identified based on their cellular expression profile and viral association [abstract]. Blood. 2002;100:316a.
35. Falini B, Fizzotti M, Pucciarini A, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood. 2000;95:2084-2092.
36. Lin KI, Angelin-Duclos C, Kuo TC, Calame K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol. 2002;22:4771-4780.
37. Shaffer AL, Lin KI, Kuo TC, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity. 2002;17:51-62.
38. Küppers R, Rajewsky K. The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. Annu Rev Immunol. 1998;16:471-493.
39. Stein H, Hummel M. Cellular origin and clonality of classic Hodgkin's lymphoma: immunophenotypic and molecular studies. Semin Hematol. 1999;36:233-241.
40. Falini B, Bigerna B, Pasqualucci L, et al. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease. Blood. 1996;87:465-471.
41. Küppers R, Klein U, Schwering I, et al. Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J Clin Invest. 2003;111:529-537.
42. Foss HD, Reusch R, Demel G, et al. Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin. Blood. 1999;94:3108-3113.
43. Levesque JP, Zannettino AC, Pudney M, et al. PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis. Immunity. 1999;11:369-378.