Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas

Leukemia

Volumn 13, Issue 7, 1999, Pages 1093-1099

  Fais, F ^a   Gaidano, G ^b   Capello, D ^b   Gloghini, A ^c   Ghiotto, F ^d   Roncella, S ^a,e   Carbone, A ^c   Chiorazzi, N ^d   Ferrarini, M ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ASL 5   (Italy)

Author keywords

Immunoglobulin variable region; Primary effusion lymphomas; Somatic mutation

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; KAPOSI SARCOMA; LYMPHOCYTE PROLIFERATION; LYMPHOMA; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0032776945     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401436     Document Type: Article

References (54)

1. Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J, Knowles DM. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996; 88: 645-656.
2. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. New Engl J Med 1995; 332: 1186-1191.
3. Carbone A, Gaidano C. HHV-8-positive body cavity-based lymphoma: a novel lymphoma entity. Br J Haematol 1997; 97: 515-522.
4. Cesarman E, Nador RG, Aozasa K, Delsol G, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus in non-AIDS related lymphomas occurring in body cavities. Am J Pathol 1996; 149: 53-57.
5. Carbone A, Gloghini A, Vaccher E, Zagonel V, Pastore C, Dalla Palma P, Branz F, Saglio G, Volpe R, Tirelli U, Gaidano G. Kaposi's sarcoma-associated herpesvirus DNA sequences in AIDS-related and AIDS-unrelated lymphomatous effusions. Br J Haematol 1996; 94: 533-543.
6. Knowles DM, Inghirami G, Ubriaco A, Dalla Pavera R. Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 1989; 73: 792-799.
7. Said W, Chien K, Takeuchi S, Tasaka T, Asou H, Cho SK, de Vos S, Cesarman E, Knowles DM, Koeffler HP. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood 1996; 87: 4937-4943.
8. Gaidano G, Gloghini A, Gattei V, Rossi MF, Cilia AM, Godeas C, Degan M, Perin T, Canzonieri V, Aldinucci D, Saglio G, Carbone A, Pinto A. Association of Kaposi's sarcoma-associated herpes-virus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood 1997; 90: 4894-4900.
9. Horenstein MG, Nador RG, Chadburn A, Hyjek EM, Inghirami G, Knowles DM, Cesarman E. Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. Blood 1997; 90: 1186-1191.
10. Komanduri K, Luce JA, McGrath MS, Herndier BG, Ng VL. The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions. J Acq Immun Def Syn Hum Retrovir 1996; 13: 215-226.
11. Chapman CJ, Zhou JX, Gregory C, Rickinson AB. Stevenson FK. VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood 1996; 88: 3562-3568.
12. Tamaru J, Hummel M, Marafioti T, Kalvelage B, Leoncini L, Minacci C, Tosi P, Wright D, Stein H. Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations. Am J Pathol 1995; 147: 1398-1407.
13. Stevenson F, Spellerberg MB, Treasure J, Chapman CJ, Silberstein LE, Hamblin TJ, Jones DB. Differential usage of an Ig heavy chain variable region gene by human B cell tumors. Blood 1993; 82: 224-230.
14. Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK. Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol 1994; 86: 505-512.
15. Vescio R, Cao J, Hong CH, Lee JC, Wu CH, Der Danielian M, Wu V, Newman R, Lichtenstein AK, Berenson JR. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. J Immunol 1995; 155: 2487-2497.
16. Sahota SS, Leo R, Hamblin TJ, Stevenson FK. Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood 1997; 89: 219-226.
17. Bakkus M, Heirman C, Van Riet I, Van Camp B, Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 1992; 80: 2326-2335.
18. Kuppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML. Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol 1996; 26: 1794-1800.
19. Schroeder HJ, Dighiero C. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today 1994; 15: 288-294.
20. Fais F, Chiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder H, Ferrarini M, Chiorazzi N. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-1525.
21. Gaidano C, Cechova K, Chang Y, Moore PS, Knowles DM, Dalla Favera R. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia 1996; 10: 1237-1240.
22. Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 1995; 86: 2708-2714.
23. Carbone A, Cilia AM, Gloghini A, Capello D, Todesco M, Quattrone S, Volpe R, Gaidano G. Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8. Br J Haematol 1998; 102: 1081-1089.
24. Gaidano G, Capello D, Cilia AM, Gloghini A, Perin T, Quattrone S, Migliazza A, Lo Coco F, Saglio G, Ascoli V, Carbone A. Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL-6: implications for disease pathogenesis and histogenesis. Genes Chrom Cancer 1999; 24: 13-23.
25. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
26. Fais F, Sellars B, Ghiotto F, Van XJ, Dono M, Allen SL, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra VP, Rai K, Stevenson FK, Gregersen PK, Ferrarini M, Chiorazzi N. Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. J Clin Invest 1996; 98: 1659-1666.
27. Jain R, Fais F, Kaplan S, Sellars B, Brooks R, Chartash E, Furie R, Hashimoto S, Chiorazzi N. IgH and L chain variable region gene sequence analyses of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors structure/function comparisons of antigenic specificity, V gene sequence, and Ig isotype. Autoimmunity 1995; 22: 229-243.
28. Jukes T, King JL. Evolutionary nucleotide replacements in DNA. Nature 1979; 281: 605-606.
29. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865-1869.
30. Williams SC, Frippiat JP, Tomlinson IM, Ignatovich O, Lefranc MP, Winter G. Sequence and evolution of the human germline V lambda repertoire. J Mol Biol 1996; 264: 220-232.
31. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994; 15: 367-373.
32. Korsmeyer S, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci USA 1981; 78: 7096-7100.
33. Ignatovich O, Tomlinson IM, Jones PT, Winter G. The creation of diversity in the human immunoglobulin V(lambda) repertoire. J Mol Biol 1997; 268: 69-77.
34. Solomon A, Weiss DT. Serologically defined V region subgroups of human lambda light chains. J Immunol 1987; 139: 824-830.
35. Farner N, Dorner T, Lipsky PE. Molecular mechanisms and selection influence the generation of the human Vlambda Jlambda repertoire. J Immunol 1999; 162: 2137-2145.
36. Perfetti V, Ubbiali P, Vignarelli MC, Diegoli M, Fasani R, Stoppini M, Lisa A, Mangione P, Obici L, Arbustini E, Merlini G. Evidence that amyloidogenic light chains undergo antigen-driven selection. Blood 1998; 91: 2948-2954.
37. Kiyoi H, Naito K, Ohno R, Saito H, Naoe T. Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma. Leukemia 1998; 12: 601-609.
38. Muller S, Wang H, Silverman GJ, Bramlet G, Haigwood N, Kohler H. B-cell abnormalities in AIDS: stable and clonally restricted antibody response in HIV-1 infection. Scand J Immunol 1993; 38: 327-334.
39. Briault S, Courtois Capella M, Duarte F, Aucouturier P, Preud'homme JL. Isotype of serum monoclonal immunoglobulins in human immunodeficiency virus-infected adults. Clin Exp Immunol 1988; 74: 182-184.
40. Tacchetti C, Favre A, Moresco L, Meszaros P, Luzzi P, Truini M, Rizzo F, Grossi CE, Ciccone E. HIV is trapped and masked in the cytoplasm of lymph node follicular dendritic cells. Am J Pathol 1997; 150: 533-542.
41. Milner E, Hufnagle WO, Glas AM, Suzuki I, Alexander C. Polymorphism and utilization of human VH Genes. Ann NY Acad Sci 1995; 764: 50-61.
42. Sasso EH, Buckner JH, Suzuki LA. Ethnic differences of polymorphism of an immunoglobulin VH3 gene. J Clin Invest 1995; 96: 1591-1600.
43. Tomlinson IM, Cook GP, Walter G, Carter NP, Riethman H, Buluwela L, Rabbitts TH, Winter G. A complete map of the human immunoglobulin VH locus. Ann NY Acad Sci 1995; 764: 43-46.
44. Matolcsy A, Nador RG, Cesarman E, Knowles DM. Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. Am J Pathol 1998; 153: 1609-1614.
45. Brezinschek HP, Foster SJ, Dorner T, Brezinschek RI, Lipsky PE. Pairing of variable heavy and variable kappa chains in individual naive and memory B cells. J Immunol 1998; 160: 4762-4767.
46. MacLennan I, Liu YJ, Johnson GD. Maturation and dispersal of B-cell clones during T cell-dependent antibody responses. Immunol Rev 1992; 126: 143-161.
47. Dono M, Hashimoto S, Fais F, Trejo V, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Sellars B, Gregersen PK, Ferrarini M, Chiorazzi N. Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification. Blood 1996; 87: 1586-1594.
48. Efremov D, Ivanovski M, Batista FD, Pozzato G, Burrone OR. IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations. J Clin Invest 1996; 98: 290-298.
49. Schettino E, Cerutti A, Chiorazzi N, Casali P. Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. J Immunol 1998; 160: 820-830.
50. Pantaleo G, Fauci AS. Immunopathogenesis of HIV infection. Annu Rev Microbiol 1996; 50: 825-854.
51. Roncella S, Cutrona G, Favre A, Ulivi M, Fais F, Signorini A, Grossi CE, Chiorazzi N, Ferrarini M. Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome. Blood 1996; 88: 599-608.
52. Przybylski G, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood 1996; 88: 4620-4629.
53. Jain R, Roncella S, Hashimoto S, Carbone A, Francia di Celle P, Foa R, Ferrarini M, Chiorazzi N. A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma. J Immunol 1994; 153: 45-52.
54. Bessudo A, Cherepakhin V, Johnson TA, Rassenti LZ, Feigal E, Kipps TJ. Favored use of immunoglobulin V(H)4 Ceres in AIDS-associated B-cell lymphoma. Blood 1996; 88: 252-260.