메뉴 건너뛰기




Volumn 2, Issue 3, 2003, Pages 599-608

Identification of in vivo enzyme activities in the cometabolism of glucose and acetate by Saccharomyces cerevisiae by using 13C-labeled substrates

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; AMINO ACID; CARBON; GLUCOSE; MALATE DEHYDROGENASE; PYRUVATE KINASE; PYRUVIC ACID;

EID: 0038482090     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.2.3.599-608.2003     Document Type: Article
Times cited : (55)

References (36)
  • 1
    • 0023876383 scopus 로고
    • Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase
    • Beltzer, J. P., S. R. Morris, and G. B. Kohlhaw. 1988. Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase. J. Biol. Chem. 263:368-374.
    • (1988) J. Biol. Chem. , vol.263 , pp. 368-374
    • Beltzer, J.P.1    Morris, S.R.2    Kohlhaw, G.B.3
  • 2
    • 0032455440 scopus 로고    scopus 로고
    • Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme
    • Boles, E., P. de Jong-Gubbels, and J. T. Pronk. 1998. Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme. J. Bacteriol. 180:2875-2882.
    • (1998) J. Bacteriol. , vol.180 , pp. 2875-2882
    • Boles, E.1    De Jong-Gubbels, P.2    Pronk, J.T.3
  • 3
    • 0030940645 scopus 로고    scopus 로고
    • Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae
    • Chen, S., J. S. Brockenbrough, J. E. Dove, and J. P. Aris. 1997. Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 16:10839-10846.
    • (1997) J. Biol. Chem. , vol.16 , pp. 10839-10846
    • Chen, S.1    Brockenbrough, J.S.2    Dove, J.E.3    Aris, J.P.4
  • 4
    • 0033987329 scopus 로고    scopus 로고
    • Metabolic network analysis. A powerful tool in metabolic engineering
    • Christensen, B., and J. Nielsen. 1999. Metabolic network analysis. A powerful tool in metabolic engineering. Adv. Biochem. Eng. Biotechnol. 66:209-231.
    • (1999) Adv. Biochem. Eng. Biotechnol. , vol.66 , pp. 209-231
    • Christensen, B.1    Nielsen, J.2
  • 6
    • 0033205580 scopus 로고    scopus 로고
    • Isotopomer analysis using GC-MS
    • Christensen, B., and J. Nielsen. 1999. Isotopomer analysis using GC-MS. Metab. Eng. 1:282-290.
    • (1999) Metab. Eng. , vol.1 , pp. 282-290
    • Christensen, B.1    Nielsen, J.2
  • 9
    • 0028953910 scopus 로고
    • Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol
    • de Jong-Gubbels, P., P. Vanrolleghem, S. Heijnen, J. P. van Dijken, and J. T. Pronk. 1995. Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol. Yeast 11:407-418.
    • (1995) Yeast , vol.11 , pp. 407-418
    • De Jong-Gubbels, P.1    Vanrolleghem, P.2    Heijnen, S.3    Van Dijken, J.P.4    Pronk, J.T.5
  • 12
    • 0022423438 scopus 로고
    • Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase
    • Falco, S. C., K. S. Dumas, and K. J. Livak. 1985. Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase. Nucleic Acids Res. 13:4011-4027.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 4011-4027
    • Falco, S.C.1    Dumas, K.S.2    Livak, K.J.3
  • 13
    • 0027363353 scopus 로고
    • Transcriptional regulation of the isocitrate lyase encoding gene in Saccharomyces cerevisiae
    • Fernandez, E., M. Fernandez, F. Moreno, and R. Rodicio. 1993. Transcriptional regulation of the isocitrate lyase encoding gene in Saccharomyces cerevisiae. FEBS Lett. 333:238-242.
    • (1993) FEBS Lett. , vol.333 , pp. 238-242
    • Fernandez, E.1    Fernandez, M.2    Moreno, F.3    Rodicio, R.4
  • 14
    • 0032900245 scopus 로고    scopus 로고
    • Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae
    • Flikweert, M. T., M. de Swaaf, J. P. van Dijken, and J. T. Pronk. 1999. Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae. FEMS Microbiol Lett. 174:73-79.
    • (1999) FEMS Microbiol. Lett. , vol.174 , pp. 73-79
    • Flikweert, M.T.1    De Swaaf, M.2    Van Dijken, J.P.3    Pronk, J.T.4
  • 15
    • 0035140099 scopus 로고    scopus 로고
    • Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression
    • Gombert, A. K., M. M. dos Santos, B. Christensen, and J. Nielsen. 2001. Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol. 183:1441-1451.
    • (2001) J. Bacteriol. , vol.183 , pp. 1441-1451
    • Gombert, A.K.1    Dos Santos, M.M.2    Christensen, B.3    Nielsen, J.4
  • 16
    • 0000773895 scopus 로고
    • Regulation of amino acid and nucleotide biosynthesis in yeast
    • J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • Jones, E. W., and G. R. Fink. 1982. Regulation of amino acid and nucleotide biosynthesis in yeast, p 181-300. In J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces: metabolism and gene expression, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • (1982) The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression , pp. 181-300
    • Jones, E.W.1    Fink, G.R.2
  • 17
    • 0026204952 scopus 로고
    • Mass isotopomer analysis: Theoretical and practical considerations
    • Lee, W.-N. P., L. O. Byerley, E. A. Bergner, and J. Edmond. 1991. Mass isotopomer analysis: theoretical and practical considerations Biol. Mass Spectrom. 20:451-458.
    • (1991) Biol. Mass Spectrom. , vol.20 , pp. 451-458
    • Lee, W.-N.P.1    Byerley, L.O.2    Bergner, E.A.3    Edmond, J.4
  • 18
    • 0026816626 scopus 로고
    • Mass isotopomer pattern and precursor-product relationship
    • Lee, W.-N. P., E. A. Bergner, and Z. K. Guo. 1992. Mass isotopomer pattern and precursor-product relationship. Biol. Mass Spectrom. 21:114-122.
    • (1992) Biol. Mass Spectrom. , vol.21 , pp. 114-122
    • Lee, W.-N.P.1    Bergner, E.A.2    Guo, Z.K.3
  • 20
    • 0030050268 scopus 로고    scopus 로고
    • Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
    • Marx, A., A. A. de Graaf, W. Wiechert, L. Eggeling, and H. Sahm. 1996. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol. Bioeng. 49:111-129.
    • (1996) Biotechnol. Bioeng. , vol.49 , pp. 111-129
    • Marx, A.1    De Graaf, A.A.2    Wiechert, W.3    Eggeling, L.4    Sahm, H.5
  • 21
    • 0030945741 scopus 로고    scopus 로고
    • Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: A key enzyme in glycine biosynthesis
    • Monschau, N., K. P. Stahmann, H. Sahm, J. B. McNeil, and A. L. Bognar. 1997. Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis. FEMS Microbiol. Lett. 150:55-60.
    • (1997) FEMS Microbiol. Lett. , vol.150 , pp. 55-60
    • Monschau, N.1    Stahmann, K.P.2    Sahm, H.3    McNeil, J.B.4    Bognar, A.L.5
  • 22
    • 0003031160 scopus 로고
    • Biomass from carbohydrates
    • Oura, E. 1983. Biomass from carbohydrates. Bio/Technology 3:3-42.
    • (1983) Bio/Technology , vol.3 , pp. 3-42
    • Oura, E.1
  • 24
    • 0034680782 scopus 로고    scopus 로고
    • In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum
    • Petersen, S., A. A. de Graaf, L. Eggeling, M. Mollney, W. Wiechert, and H. Sahm. 2000. In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum. J. Biol. Chem. 275:35932-35941.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35932-35941
    • Petersen, S.1    De Graaf, A.A.2    Eggeling, L.3    Mollney, M.4    Wiechert, W.5    Sahm, H.6
  • 25
    • 0030448870 scopus 로고    scopus 로고
    • Pyruvate metabolism in Saccharomyces cerevisiae
    • Pronk, J. T., H. Y. Steensma, and J. P. van Dijken. 1999. Pyruvate metabolism in Saccharomyces cerevisiae. Yeast 16:1607-1633.
    • (1999) Yeast , vol.16 , pp. 1607-1633
    • Pronk, J.T.1    Steensma, H.Y.2    Van Dijken, J.P.3
  • 26
    • 0004737031 scopus 로고    scopus 로고
    • Understanding microbial obesity
    • Ratledge, C., and J. Wynn. 2000. Understanding microbial obesity. ASM News 50:181-185.
    • (2000) ASM News , vol.50 , pp. 181-185
    • Ratledge, C.1    Wynn, J.2
  • 28
    • 0029146299 scopus 로고
    • 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism
    • 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism. Eur. J. Biochem. 232:433-448.
    • (1995) Eur. J. Biochem. , vol.232 , pp. 433-448
    • Szyperski, T.1
  • 29
    • 0022382351 scopus 로고
    • Characteristics of alanine:glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates
    • Takada, Y., and T. Noguchi. 1985. Characteristics of alanine:glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates. Biochem. J. 231:157-163.
    • (1985) Biochem. J. , vol.231 , pp. 157-163
    • Takada, Y.1    Noguchi, T.2
  • 30
    • 0029134555 scopus 로고
    • ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose
    • van den Berg, M., and H. Y Steensma. 1995. ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose. Eur. J. Biochem. 231:704-713.
    • (1995) Eur. J. Biochem. , vol.231 , pp. 704-713
    • Van Den Berg, M.1    Steensma, H.Y.2
  • 31
    • 0032530934 scopus 로고    scopus 로고
    • Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: Application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism
    • van den Berg, M., P. de Jong-Gubbels, and H. Y. Steensma. 1998. Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. Yeast 14:1089-1104.
    • (1998) Yeast , vol.14 , pp. 1089-1104
    • Van Den Berg, M.1    De Jong-Gubbels, P.2    Steensma, H.Y.3
  • 32
    • 0026710123 scopus 로고
    • Effect of benzoic acid on metabolic fluxes in yeasts: A continuous-culture study on the regulation of respiration and alcoholic fermentation
    • Verduyn, C., E. Postma, W. A. Scheffers, and J. P. van Dijken. 1992. Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 8:501-517.
    • (1992) Yeast , vol.8 , pp. 501-517
    • Verduyn, C.1    Postma, E.2    Scheffers, W.A.3    Van Dijken, J.P.4
  • 34
    • 0026334731 scopus 로고
    • Physiology of yeasts in relation to biomass yields
    • Verduyn, C. 1991. Physiology of yeasts in relation to biomass yields. Antonie Leeuwenhoek 60:325-353.
    • (1991) Antonie Leeuwenhoek , vol.60 , pp. 325-353
    • Verduyn, C.1
  • 35
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks. 1. Modeling and simulation of carbon isotope labeling experiments
    • Wiechert, W., and A. A. de Graaf. 1997. Bidirectional reaction steps in metabolic networks. 1. Modeling and simulation of carbon isotope labeling experiments. Biotechnol. Bioeng. 55:101-117.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 101-117
    • Wiechert, W.1    De Graaf, A.A.2
  • 36
    • 0033905714 scopus 로고    scopus 로고
    • 13C-labeling experiments and nuclear magnetic resonance analysis
    • 13C-labeling experiments and nuclear magnetic resonance analysis. J. Bacteriol. 182:4632-4636.
    • (2000) J. Bacteriol. , vol.182 , pp. 4632-4636
    • Xavier, K.B.1    Da Costa, M.S.2    Santos, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.