Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: A key enzyme in glycine biosynthesis

FEMS Microbiology Letters

Volumn 150, Issue 1, 1997, Pages 55-60

  Monschau, Nicole ^a   Stahmann, K Peter ^a   Sahm, Hermann ^a   McNeil, J Bryan ^b   Bognar, Andrew L ^c  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b AMGEN INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

GLY1 gene; glycine biosynthesis; Saccharomyces cerevisiae; threonine aldolase

Indexed keywords

GLYCINE; THREONINE; THREONINE ALDOLASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FUNGUS MUTANT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ALANINE TRANSAMINASE; ETHANOL; FUNGAL PROTEINS; GLUCOSE; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; KINETICS; MODELS, CHEMICAL; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSAMINASES;

EID: 0030945741     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00096-7     Document Type: Article

References (16)

1. Ulane, R. and Ogur, M. (1972) Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces. J. Bacteriol. 109, 34-43.
2. McNeil, J.B., McIntosh, E.M., Taylor, B.V., Zhang, F., Tang, S. and Bognar, A.L. (1994) Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. J. Biol. Chem. 269, 9155-9165.
3. Stauffer, G.V., Plamann, M.D. and Stauffer, L.T. (1981) Construction and expression of hybrid plasmids containing the Escherichia coli gly A gene. Gene 14, 63-72.
4. Chasin, L.A., Feldman, A., Konstam, M. and Urlaub, G. (1974) Reversion of a Chinese hamster cell auxotrophic mutant. Proc. Natl. Acad. Sci. USA 71, 718-722.
5. McNeil, J.B., Bognar, A.L. and Pearlman, R.E. (1996) In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae. Genetics 142, 371-381.
6. McClung, C.R., Davis, C.R., Page, K.M. and Denome, S.A. (1992) Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyltransferase of Neurospora crassa. Mol. Cell. Biol. 12, 1412-1421.
7. Takada, Y. and Noguchi, T. (1985) Characteristics of alanine:glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates. Biochem. J. 231, 157-163.
8. Mehta, P.K., Hale, T.I. and Christen, P. (1993) Aminotransferases: demonstration of homology and division into evolutionary subgroups. Eur. J. Biochem. 214, 549-561.
9. Murata, K., Saikusa, T., Fukuda, Y., Watanabe, K., Inoue, Y., Shimosaka, M. and Kimura, A. (1986) Metabolism of 2-oxoaldehydes in yeast. Eur. J. Biochem. 157, 297-301.
10. Schirch, L. and Diller, A. (1971) Serine transhydroxymethylase. J. Biol. Chem. 246, 3961-3966.
11. Schirch, V., Hopkins, S., Villar, E. and Angelaccio, S. (1985) Serine hydroxymethyltransferase from Escherichia coli: purification and properties. J. Bacteriol. 163, 1-7.
12. Willets, A.J. and Turner, J.M. (1971) L-Threonine aetaldehyde-lyase in a strain of Bacillus subtilis. Biochim. Biophys. Acta 252, 105-110.
13. Dainty, R.H. (1970) Purification and properties of threonine aldolase from Clostridium pasteurianum. Biochem. J. 117, 585-592.
14. Diaz-Diaz, M., Ward, O.P., Honek, J. and Lajoie, G. (1995) Enzymes from Pseudomonas sp. strain NCIB11097 participating in biotransformation of acetaldehyde and glycine to threonine isomers. Can. J. Microbiol. 41, 438-443.
15. Yamada, H., Kumagai, H., Nagate, T. and Yoshida, H. (1971) Formation of threonine aldolase by bacteria and yeasts. Agric. Biol. Chem. 35, 1340-1345.
16. Pascarella, S., Schirch, V. and Bossa, F. (1993) Similarity between serine hydroxymethyltransferase and other pyridoxal phosphate-dependent enzymes. FEBS Lett. 331, 145-149.