Flow injection analysis NMR (FIA-NMR): A novel flow NMR technique that complements LC-NMR and direct injection NMR (DI-NMR)

Magnetic Resonance in Chemistry

Volumn 41, Issue 7, 2003, Pages 509-516

  Keifer, Paul A ^a,b  

^a Varian Inc   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

1H NMR; Combinatorial chemistry; DI NMR; Drug discovery; FIA NMR; LC NMR; NMR; Quantification

Indexed keywords

BIOCHIPS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY;

1H NMR; COMBINATORIAL CHEMISTRY; DIRECT INJECTION NMR; DRUG DISCOVERY; FLOW INJECTION ANALYSE NMR; FLOW INJECTION ANALYSIS; LC-NMR; NMR TECHNIQUES; OVER THE COUNTERS; QUANTIFICATION;

DIRECT INJECTION;

ANALYTIC METHOD; ARTICLE; COMBINATORIAL CHEMISTRY; FEASIBILITY STUDY; FLOW INJECTION ANALYSIS; FLOW KINETICS; LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; VALIDATION PROCESS;

EID: 0038463778     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.1206     Document Type: Article

References (49)

1. Watanabe N, Niki E. Proc. Jpn. Acad. Ser. B 1978; 54: 194.
2. Dorn HC. Anal. Chem. 1984; 56: 747A.
3. Laude DA, Jr, Wilkins CL. Trends Anal. Chem. 1986; 5: 230.
4. Albert K, Bayer E. Trends Anal. Chem. 1988; 7: 288.
5. Albert K. J. Chromatogr. 1995; 703: 123.
6. Lindon JC, Nicholson JK, Wilson ID. Adv. Chromatogr. 1996; 36: 315.
7. Lindon JC, Nicholson JK, Wilson ID. Prog. Nucl. Magn. Reson. Spectrosc. 1996; 29: 1.
8. Lindon JC, Nicholson JK, Sidelmann UG, Wilson ID. Drug Metab. Rev. 1997; 29: 705.
9. Ehlhardt WJ, Woodland JM, Baughman TM, Vandenbranden M, Wrighton SA, Kroin JS, Norman BH, Maple SR. Drug Metab. Dispos. 1998; 26: 42.
10. Strohschein S, Schlotterbeck G, Richter J, Pursch M, Tseng L-H, Händel H, Albert K. J. Chromatogr. 1997; 765: 207.
11. Strohschein S, Pursch M, Händel H, Albert K. Fresenius' J. Anal. Chem. 1997; 357: 498.
12. Sidelmann UG, Lenz EM, Spraul M, Hofmann M, Troke J, Sanderson PN, Lindon JC, Wilson ID, Nicholson JK. Anal. Chem. 1996; 68: 106.
13. Wolfender J-L, Rodriguez S, Hostettmann K. J. Chromatogr. 1998; 794: 299.
14. Spring O, Heil N, Vogler B. Phytochemistry 1997; 46: 1369.
15. Wolfender J-L, Rodriguez S, Hostettmann K, Hiller W. Phytochem. Anal. 1997; 8: 97.
16. Keifer PA. Drug Discov. Today 1997; 2: 468.
17. Keifer PA. Drugs Future 1998; 23: 301.
18. Keifer PA, Smallcombe SH, Williams EH, Salomon KE, Mendez G, Belletire JL, Moore CD. J. Comb. Chem. 2000; 2: 151.
19. Hamper BC, Synderman DM, Owen TJ, Scates AM, Owsley DC, Kesselring AS, Chott RC. J. Comb. Chem. 1999; 1: 140.
20. Freedman DS, Otvos JD, Jeyarajah EJ, Barboriak JJ, Anderson AJ, Walker JA. Arterioscler. Thromb. Vasc. Biol. 1998; 18: 1046.
21. Shuker SB, Hajduk PJ, Meadows RP, Fesik SW. Science 1996; 274: 1531.
22. Smallcombe SH, Patt SL, Keifer PA. J. Magn. Reson. A 1995; 117: 295.
23. Rosen ME. J. Magn. Resort. A 1994; 107: 119.
24. Smallcombe SH. J. Am. Chem. Soc. 1993; 115: 4776.
25. Curran SA, Williams DE. Appl. Spectrosc. 1987; 41: 1450.
26. Ruzicka J, Hansen EH. Anal. Chim. Acta 1975; 78: 145.
27. Christian GD, Ruzicka J. Spectrochim. Acta, Part B 1987; 42: 157.
28. Tyson JF. Analyst 1985; 110: 419.
29. Burguera JL (ed.). Flow Injection Atomic Spectroscopy. Marcel Dekker: New York, 1989; 1-347.
30. Ruzicka J, Hansen EH. Anal. Chim. Acta 1986; 179: 1.
31. Ruzicka J. Analyst 1994; 119: 1925.
32. Patton CJ, Wade AP. In Analytical Instrumentation Handbook, Ewing GW (ed). Marcel Dekker: New York, 1997; 125-220.
33. Ruzicka J, Hansen EH. Flow Injection Analyses. Wiley: New York, 1988.
34. Karlberg B, Pacey GE. Flow Injection Analysis - A Practical Guide. Elsevier: New York, 1989.
35. Fang Z. Flow Injection Separation and Preconcentration. VCH: New York, 1993.
36. Ruzicka J, Christian GD. Analyst 1990; 115: 475.
37. Spraul M, Hofmann M, Ackermann M, Shockcor JP, Lindon JC, Nicholls AW, Nicholson JK, Damment SJP, Haselden JN. Anal. Commun. 1997; 34: 339.
38. Ruzicka J, Hansen EH. Anal. Chim. Acta 1980; 114: 19.
39. Pasquini C, de Oliveira WA. Anal. Chem. 1985; 57: 2575.
40. Patton CJ, Crouch SR. Anal. Chim. Acta 1986; 179: 189.
41. Pasquini C. Anal. Chem. 1986; 58: 2346.
42. Traficante DD. Concepts Magn. Reson. 1992; 4: 153.
43. Louden D, Handley A, Taylor S, Lenz E, Miller S, Wilson ID, Sage A. Analyst 2000; 125: 927.
44. Lenz E, Taylor S, Collins C, Wilson ID, Louden D, Handley A. J. Pharm. Biomed. Anal. 2002; 27: 191-200.
45. Keifer PA. Prog. Drug Res. 2000; 55: 137.
46. Stockman BJ, Farley KA, Angwin DT. Methods Enzymol. 2001; 338: 230.
47. Albert K. (ed). On-Line LC-NMR and Related Techniques. Wiley: Chichester, 2002.
48. Keifer PA. In Integrated Drug Discovery Technologies, Mei H-Y, Czarnik AW (eds). Marcel Dekker: New York, 2002; 485-541.
49. Keifer PA. Curr. Opin. Chem. Biol. 2003; 7: in press.