Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract

Peptides

Volumn 23, Issue 3, 2002, Pages 479-488

  Krondahl, Eva ^a,b   Tronde, Ann ^a,c   Eirefelt, Stefan ^c   Forsmo Bruce, Heidi ^b   Ekström, Gunilla ^b   Bengtsson, Ursula Hultkvist ^c   Lennernäs, Hans ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Bioavailability; Deamidation; Drug delivery; First pass metabolism; Inhalation; Nasal; Opioid peptide; Pharmacokinetics; Pulmonary; Rat; Regional absorption; Respiratory tract

Indexed keywords

DRUG METABOLITE; OPIATE; TETRAPEPTIDE; TYROSYL DEXTRO ARGINYLPHENYLALANYLPHENYLALANINE AMINE; UNCLASSIFIED DRUG;

AEROSOL; ANALYTIC METHOD; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; DEAMINATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG INFUSION; FIRST PASS EFFECT; IN VIVO STUDY; LUNG; MALE; NEBULIZATION; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM;

EID: 0036166578     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(01)00629-5     Document Type: Article

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