Direct interaction of serotonin type 3 receptor ligands with recombinant and native α9α10-containing nicotinic cholinergic receptors

Molecular Pharmacology

Volumn 63, Issue 5, 2003, Pages 1067-1074

  Rothlin, Carla V ^a   Lioudyno, Maria I ^b   Silbering, Ana F ^a   Plazas, Paola V ^a   Gomez Casati, María E ^a   Katz, Eleonora ^a   Guth, Paul S ^b   Elgoyhen, Ana Belén ^a,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BIOGENIC AMINE; ION CHANNEL; NICOTINIC RECEPTOR; ONDANSETRON; RECOMBINANT RECEPTOR; SEROTONIN; SEROTONIN 3 ANTAGONIST; TROPISETRON;

ANIMAL CELL; ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; CORTI ORGAN; DRUG POTENCY; DRUG RECEPTOR BINDING; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; VESTIBULAR SYSTEM; XENOPUS LAEVIS;

ANIMALS; ELECTROPHYSIOLOGY; HAIR CELLS; INDOLES; OOCYTES; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT PROTEINS; SEROTONIN; XENOPUS LAEVIS;

EID: 0038407459     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.5.1067     Document Type: Article

References (37)

1. Anand R, Conroy W, Schoepfer R, Whiting P, and Lindstrom J (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 266:11192-11198.
2. Arias H (1998) Noncompetitive inhibition of nicotinic acetylcholine receptors by endogenous molecules. J Neurosci Res 52:369-379.
3. Athas GB, Norris CH, Guth PS, and Garcia MM (1997) Expression profiling of vestibular hair cells from the frog. Assoc Res Otolaryng Abs 20:37.
4. Bobbin RP and Thompson MH (1978) Effects of putative transmitters on afferent cochlear transmission. Ann Otol Rhinol Laryngol 87:185-190.
5. Cachelin AB and Rust G (1994) Unusual pharmacology of (+)-tubocurarine with rat neuronal nicotinic acetylcholine receptors containing β4 subunits. Mol Pharmacol 46:1168-1174.
6. Cooper E, Couturier S, and Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature (Lond) 350:235-238.
7. 3B receptor subunit. J Biol Chem 274:30799-30810.
8. Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, and Heinemann S (1994) Alpha9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715.
9. Elgoyhen AB, Vetter D, Katz E, Rothlin C, Heinemann S, and Boulter J (2001) Alpha 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci USA 98:3501-3506.
10. + in guinea pig outer hair cells. Hearing Res 81:119-129.
11. Fuchs P (1996) Synaptic transmission at vertebrate hair cells. Curr Opin Neurobiol 6:514-519.
12. Galzi J-L, Revah F, Bessis A, and Changuex JP (1991) Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Annu Rev Pharmacol 31:37-72.
13. Gil-Loyzaga P, Bartolomé MV, and Vicente-Torres MA (1997a) Serotonergic innervation of the organ of Corti of the cat cochlea. Neuroreport 8:3519-3522.
14. Gil-Loyzaga P, Bartolomé V, Vicente-Torres A, and Carricondo F (2000) Serotonergic innervation of the organ of Corti. Acta Otolaryngol 120:128-132.
15. Gil-Loyzaga P, Vicente-Torres MA, Garcia-Bonacho M, and Esquifino A (1997b) Presence of catecholamines and serotonin in the rat vestibule. Brain Res 746:265-268.
16. Hesketh PJ (2000) Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting. Cancer Investig 18:163-173.
17. Hiel H, Elgoyhen AB, Drescher D, and Morley B (1996) Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system. Brain Res 738:347-352.
18. Holt JC, Lioudyno M, Athas G, Garcia MM, Perin P, and Guth PS (2001) The effect of proteolytic enzymes on the α9-nicotinic receptor-mediated response in isolated frog vestibular hair cells. Hearing Res 152:25-42.
19. Johnson DS and Heinemann SF (1995) Embryonic expression of the 5-HT3 receptor subunit, 5-HT3-A, in the rat: an in situ hybridization study. Mol Cell Neurosci 6:122-138.
20. Karlin A (2002) Ion channel structure: emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 3:102-114.
21. Katz E, Verbitsky M, Rothlin C, Vetter D, Heinemann S, and Elgoyhen AB (2000) High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor. Hearing Res 141:117-128.
22. Le Novére N and Changeux JP (1999) The ligand gated channel database. Nucleic Acids Res 27:340-342.
23. + channel determined by construction of multimeric cDNAs. Neuron 9:861-871.
24. Lioudyno M, Verbitsky M, Holt J, Elgoyhen AB, and Guth P (2000) Morphine inhibits an α9-acetylcholine nicotinic receptor-mediated response by a mechanism which does not involve opioid receptors. Hearing Res 149:167-177.
25. Macor JE, Gurley D, Lanthorn T, Loch J, Mack RA, Mullen G, Tran O, Wright N, and Gordon JC (2001) The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective nicotinic receptor partial agonist. Bioorg Med Chem Lett 11:319-321.
26. Maricq A, Peterson A, Brake A, Myers R, and Julius D (1991) Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (Wash DC) 254:432-436.
27. Morley B, Li H, Hiel H, Drescher D, and Elgoyhen AB (1998) Identification of the subanits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization. Mol Brain Res 53:78-87.
28. Nakazawa K, Akiyama T, and Inoue K (1995) Block by 5-hydroxytryptamine of neuronal acetylcholine receptor channels expressed in Xenopus oocytes. Cell Mol Neurobiol 15:495-500.
29. Palma E, Miledi AM, Eusebi F, and Miledi R (1996) Threonine-for-leucine mutation within domain M2 of the neuronal α7 nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist. Proc Natl Acad Sci USA 93:11231-11235.
30. Pasricha PJ (2001) Prokinetic agents, antiemetics and agents used in irritable bowel syndrome, in Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman JG and Limbird LE eds) pp 1021-1036, McGraw Hill, New York.
31. Rothlin C, Verbitsky M, Katz E, and Elgoyhen AB (1999) The α9 nicotinic acetylcholine receptor shares pharmacological properties with type A γ-aminobutyric acid, glycine and type 3 serotonin receptors. Mol Pharmacol 55:248-254.
32. Spier AD and Lummis SCR (2000) The role of tryptophan residues in the 5-Hydroxytryptamine3 receptor ligand binding domain. J Biol Chem 275:5620-5625.
33. Turconi M, Donetti A, Schiavone A, Sagrada A, Montagna E, Nicola M, Cesana R, Rizzi C, and Micheletti R (1991) Pharmacological properties of a novel class of 5-HT3 receptor antagonists. Eur J Pharmacol 203:203-211.
34. Vanner S and Sruprenant A (1990) Effects of 5-HT3 receptor antagonists on 5-HT and nicotinic depolarizations in guinea-pig submucosal neurones. Br J Pharmacol 99:840-844.
35. Venkataraman P, Ma C, Kirschbaum KS, and Schulte MK (1999) Tryptophan 89 of the 5HT3 receptor forms a cation-π interaction with the amino group of 5HT3R. Soc Neurosci Abstr 25:202.
36. Yan D, Schulte MK, Bloom KE, and White MM (1999) Structural features of the ligand-binding domain of the serotonin 5HT3 receptor. J Biol Chem 274:5537-5541.
37. Zwart R and Vjiverberg HPM (1997) Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and non-competitive effects. Mol Pharmacol 52:886-895.