Anti-apoptotic defense of bcl-2 gene against hydroperoxide-induced cytotoxicity together with suppressed lipid peroxidation, enhanced ascorbate uptake, and upregulated Bcl-2 protein

Journal of Cellular Biochemistry

Volumn 89, Issue 2, 2003, Pages 321-334

  Saitoh, Yasukazu ^a,b   Ouchida, Rika ^a,c   Kayasuga, Atsushi ^a   Miwa, Nobuhiko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b Ophtecs Corporation   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bcl 2; Cytotoxicity; Intracellular vitamin C; Reactive oxygen species (ROS); Tert butyl hydroperoxide

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CARBON 14; CASPASE 3; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DENSITY; CELL PROTECTION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CLEAVAGE; DNA STRAND; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; INTRACELLULAR TRANSPORT; ISOTOPE LABELING; LIPID PEROXIDATION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TIME; UPREGULATION;

ANIMALS; APOPTOSIS; ASCORBIC ACID; CASPASE 1; CASPASE 3; CASPASES; CELL LINE; CELL SURVIVAL; GENES, BCL-2; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; LIPID PEROXIDATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; UP-REGULATION;

EID: 0038372562     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10506     Document Type: Article

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