Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats

Journal of Ethnopharmacology

Volumn 87, Issue 1, 2003, Pages 109-113

  Petrovic, Silvana D ^a   Dobric, Silva ^b   Bokonjic, Dubravko ^b   Niketic, Marjan ^c   García Piñeres, Alfonso ^d   Merfort, Irmgard ^d  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF DEFENCE   (Serbia)

^c Natural History Museum   (Yugoslavia)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti inflammatory; Gastric anti ulcer; NF B; Tanacetum larvatum extract

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; TENACETUM LARVATUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; DRUG MEGADOSE; DRUG SCREENING; GEL MOBILITY SHIFT ASSAY; INHIBITION KINETICS; MALE; MEDICINAL PLANT; NONHUMAN; PAW EDEMA; RAT; STATISTICAL SIGNIFICANCE; STOMACH PROTECTION; STOMACH ULCER; TENACETUM LARVATUM; ULCEROGENESIS;

TANACETUM LARVATUM;

EID: 0038350856     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(03)00118-1     Document Type: Article

References (26)

1. Adami E., Marazzi-Uberti E., Turba C. Pharmacological research on gefarnate, a new synthetic isoprenoid with an anti-ulcer action. Archives Internationales de Pharmacodynamie et de Therapie. 147:1964;113-145.
2. Baeuerle P., Henkel T. Function and activation of NF-κB in the immune system. Annual Review of Immunology. 12:1994;141-179.
3. Bork P.M., Schmitz L., Kuhnt M., Escher C., Heinrich M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB. FEBS Letters. 402:1997;85-90.
4. Gajic, M., 1975. Tanacetum L. In: Josifovic, M. (Ed.), The Flora of FR Serbia, vol. VII. SANU, Belgrade.
5. García-Piñeres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., Merfort I. Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. The Journal of Biological Chemistry. 276:2001;39713-39720.
6. Ghanayem B.I., Matthews H.B., Maronpot R.R. Calcium channel blockers protect against ethanol- and indomethacin-induced gastric lesions in rats. Gastroenterology. 92:1987;106-111.
7. Gilroy D.W., Colville-Nash P.R., Willis D., Chivers J., Paul-Clark M.J., Willoughby D.A. Inducible cyclooxygenase may have anti-inflammatory properties. Nature Medicine. 5:1999;698-701.
8. Gracioso J.S., Hiruma-Lima C.A., Souza Brito A.R.M. Antiulcerogenic effect of a hydroalcoholic extract and its organic fractions of Neurolaena lobata (L.) R.BR. Phytomedicine. 7:2000;283-289.
9. Heptinstall S., Awang D.V., Dawson B.A., Kindack D., Knight D.W., May J. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products. Journal of Pharmacy and Pharmacology. 44:1992;391-395.
10. Hwang D., Fischer N.H., Yang B.C., Tak H., Kim J.K., Lee W. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochemical and Biophysical Research Communications. 226:1996;810-818.
11. Ianaro A., Ialenti A., Maffia P., Pisano B., Di Rosa M. Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Letters. 508:2001;61-66.
12. Jain N.K., Kulkarni S.K. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. Journal of Ethnopharmacology. 68:1999;251-259.
13. Konturek S.J., Obtulowicz W., Kwiecien N., Oleksy J. Generation of prostaglandins in gastric mucosa of patients with petic ulcer disease: effect of nonsteroidal antiinflammatory compounds. Scandinavian Journal of Gastroentrology - Suppl. 101:1984;75-77.
14. Maria A.O.M., Franchi A.M., Wendel G.H., Gimeno M., Guzman J.A., Giordano O.S., Guerreiro E. Gastric cytoprotective activity of dehydroleucodine in rats. Role of prostaglandins. Biological and Pharmaceutical Bulletin. 21:1998;335-338.
15. 2 receptor antagonist with gastroprotective activity. Folia Pharmacologica Japonica. 117:2001;377-386.
16. Oyanagui Y., Sato S. Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. Arzneimittelforschung Drug Research. 41:1991;5.
17. Pantocsek J. Plantae novae quas aestate anni 1872 per Hercegovinam et Montenigro collexit et descripsit. Österreichische Botanische Zeitschrift. 23:1873;265-268.
18. Passreiter C., Wendisch D., Gondol D. Sesquiterpene lactones from Neurolaena lobata. Phytochemistry. 39:1995;133-137.
19. Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., Santoro M.G. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 403:2000;103-108.
20. Rüngeler P., Castro V., Mora G., Gören N., Vichnewski W., Pahl H.L., Merfort I., Schmidt T.J. Inhibition of transcription factor NF-κB by sesquiterpene lactones - a proposed molecular mechanism of action. Biorganic and Medicinal Chemistry. 7:1999;2343-2352.
21. Schinella G.R., Giner R.-M., Del Carmen Recio M., Mordujovich de Buschiazzo P., Rios J.-L., Manez S. Anti-inflammatory effects of south American Tanacetum vulgare. Journal of Pharmacy and Pharmacology. 50:1998;1069-1074.
22. Schmidt T.J. Sesquiterpene lactones - structural and biochemical aspects. Current Organic Chemistry. 3:1999;577-605.
23. Silván A.M., Abad M.J., Bermejo P., Villar A. Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA-induced mouse ear oedema. Inflammation Research. 45:1996;289-292.
24. Silván A.M., Abad M.J., Bermejo P., Villar A. Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems. Planta Medica. 64:1998;200-203.
25. Tournier H., Schinella G., Balsa E.M., Buschiazzo H., Mañez S., Mordujovich-Buschiazzo P. Effect of the chloroform extract of Tanacetum vulgare and one of its active principles, parthenolide, on experimental gastric ulcer in rats. Journal of Pharmacy and Pharmacology. 51:1999;215-219.
26. Vajs V., Milosavljevic S., Aljancic I., Todorovic N., Menkovic N., Bulatovic V. Parthenolide content of Tanacetum larvatum, endemic species of Montenegro. Archives of Pharmacy. 3/4:2000;252-253.