A facile synthesis of 3-aryl pyroglutamic acid. Facile synthesis of baclofen and chlorpheg

Tetrahedron Letters

Volumn 44, Issue 28, 2003, Pages 5271-5273

  Chang, Meng Yang ^a   Sun, Pei Pei ^b   Chen, Shui Tein ^a   Chang, Nein Chen ^b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Baclofen; Chlorpheg; Glutarimides; Pyroglutamic acid; Stepwise 3+2 annulation

Indexed keywords

4 AMINO 3 (3 CHLOROPHENYL)GLUTAMIC ACID; ACETAMIDE DERIVATIVE; ACRYLIC ACID DERIVATIVE; BACLOFEN; BACLON; GLUTAMIC ACID DERIVATIVE; PYROGLUTAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DECARBOXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; RACEMIC MIXTURE;

EID: 0038345960     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01278-4     Document Type: Article

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44. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
45. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
46. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
47. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
48. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
49. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
50. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
51. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
52. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
53. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
54. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
55. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
56. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
57. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
58. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
59. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
60. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
61. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
62. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
63. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
64. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
65. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
66. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
67. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
68. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995, 43, 1302; (j) Ibuka, T.; Schoenfelder, A.; Bildstein, P.; Mann, A. Synth. Commun. 1995, 25, 1777; (k) Prager, R. H.; Schafer, K.; Hamon, D. P. G.; Massy-Westropp, R. A. Tetrahedron 1995, 51, 11465; (l) Langlois, N.; Dahuron, N.; Wang, H. S. Tetrahedron 1996, 52, 15117; (m) Caira, M. R.; Clauss, R.; Nassimbeni, L. R.; Scott, J. L.; Wildervanck, A. F. J. Chem. Soc., Perkin Trans. 2 1997, 763; (n) Mazzini, C.; Lebreton, J.; Alphand, V.; Furstoss, R. Tetrahedron Lett. 1997, 38, 1195; (o) Coelho, F.; de Azevedo, M. B. M.; Boschiero, R.; Resende, P. Synth. Commun. 1997, 27, 2455; (p) Brenna, E.; Caraccia, N.; Fuganti, C.; Fuganti, D.; Grasselli, P. Tetrahedron: Asymmetry 1997, 8, 3801; (q) Anada, M.; Hashimoto, S.-i. Tetrahedron Lett. 1998, 39, 79; (r) Resende, P.; Almeida, W. P.; Coelho, F. Tetrahedron: Asymmetry 1999, 10, 2113; (s) Licandro, E.; Maiorana, S.; Baldoli, C.; Capella, L.; Perdicchia, D. Tetrahedron: Asymmetry 2000, 11, 975; (t) Baldoli, C.; Maiorana, S.; Licandro, E.; Perdicchia, D.; Vandoni, B. Tetrahedron: Asymmetry 2000, 11, 2007; (u) Corey, E. J.; Zhang, F.-Y. Org. Lett. 2000, 2, 4257; (v) Carpes, M. J. S.; Correia, C. R. D. Tetrahedron Lett. 2002, 43, 741; (w) Doyle, M. P.; Hu, W. Chirality 2002, 14, 169; (x) Herdeis, C.; Kelm, B. Tetrahedron 2003, 59, 217; (y) Thakur, V. V.; Nikalje, M. D.; Sudalai, A. Tetrahedron: Asymmetry 2003, 14, 581; (z) Hayashi, M.; Ogasawara, K. Heterocycles 2003, 59, 785.
69. Synthesis of baclofen: (a) Allan, R. D.; Tran, H. Aust. J. Chem. 1981, 34, 2641; (b) Wall, G. M.; Baker, J. K. J. Med. Chem. 1989, 32, 1340; (c) Allen, R. D.; Bates, M. C.; Drew, C. A.; Duke, R. K.; Hambley, T. W.; Johnston, G. A. R.; Mewett, K. N.; Spence, I. Tetrahedron 1990, 46, 2511; (d) Chenevert, R.; Desjardins, M. Tetrahedron Lett. 1991, 32, 4249; (e) Herdeis, C.; Hubmann, H. P. Tetrahedron: Asymmetry 1992, 3, 1213; (f) Schoenfelder, A.; Mann, A.; Le Coz, S. Synlett 1993, 63; (g) Jefford, C. W.; McNulty, J. A. Helv. Chim. Acta 1994, 77, 2146; (h) Chenevert, R.; Desjardins, M. Can. J. Chem. 1994, 72, 2312; (i) Yoshifuji, S.; Kaname, M. Chem. Pharm. Bull. 1995,
70. Synthesis of chlorpheg: (a) David, E. J.; David, J. C.; Judith, A. K.; Howard, I. C.; Kilpatrick, D. C.; Sunter, G. A.; Thompson, P. M.; Udvarhelyi, C. Wilson; Jeffrey, C. W. J. Med. Chem. 1996, 39, 4738; (b) Herdeis, C.; Hubmann, H. P.; Lotter, H. Tetrahedron: Asymmetry 1994, 5, 351; (c) Sin, K. S.; Sung, S. Y.; Kim, K. H.; Lee, C. K.; Jun, J. G.; Pachaly, P. Arch. Pharm. (Weinheim Ger.), 1991, 324, 501; (d) for 3-phenyl analogs: Ezquerra, J.; Pedregal, C.; Merino, I.; Flórez, J.; Barluenga, J.; García-Granda, S.; Llorca, M.-A. J. Org. Chem. 1999, 64, 6554.
71. Synthesis of chlorpheg: (a) David, E. J.; David, J. C.; Judith, A. K.; Howard, I. C.; Kilpatrick, D. C.; Sunter, G. A.; Thompson, P. M.; Udvarhelyi, C. Wilson; Jeffrey, C. W. J. Med. Chem. 1996, 39, 4738; (b) Herdeis, C.; Hubmann, H. P.; Lotter, H. Tetrahedron: Asymmetry 1994, 5, 351; (c) Sin, K. S.; Sung, S. Y.; Kim, K. H.; Lee, C. K.; Jun, J. G.; Pachaly, P. Arch. Pharm. (Weinheim Ger.), 1991, 324, 501; (d) for 3-phenyl analogs: Ezquerra, J.; Pedregal, C.; Merino, I.; Flórez, J.; Barluenga, J.; García-Granda, S.; Llorca, M.-A. J. Org. Chem. 1999, 64, 6554.
72. Synthesis of chlorpheg: (a) David, E. J.; David, J. C.; Judith, A. K.; Howard, I. C.; Kilpatrick, D. C.; Sunter, G. A.; Thompson, P. M.; Udvarhelyi, C. Wilson; Jeffrey, C. W. J. Med. Chem. 1996, 39, 4738; (b) Herdeis, C.; Hubmann, H. P.; Lotter, H. Tetrahedron: Asymmetry 1994, 5, 351; (c) Sin, K. S.; Sung, S. Y.; Kim, K. H.; Lee, C. K.; Jun, J. G.; Pachaly, P. Arch. Pharm. (Weinheim Ger.), 1991, 324, 501; (d) for 3-phenyl analogs: Ezquerra, J.; Pedregal, C.; Merino, I.; Flórez, J.; Barluenga, J.; García-Granda, S.; Llorca, M.-A. J. Org. Chem. 1999, 64, 6554.
73. Synthesis of chlorpheg: (a) David, E. J.; David, J. C.; Judith, A. K.; Howard, I. C.; Kilpatrick, D. C.; Sunter, G. A.; Thompson, P. M.; Udvarhelyi, C. Wilson; Jeffrey, C. W. J. Med. Chem. 1996, 39, 4738; (b) Herdeis, C.; Hubmann, H. P.; Lotter, H. Tetrahedron: Asymmetry 1994, 5, 351; (c) Sin, K. S.; Sung, S. Y.; Kim, K. H.; Lee, C. K.; Jun, J. G.; Pachaly, P. Arch. Pharm. (Weinheim Ger.), 1991, 324, 501; (d) for 3-phenyl analogs: Ezquerra, J.; Pedregal, C.; Merino, I.; Flórez, J.; Barluenga, J.; García-Granda, S.; Llorca, M.-A. J. Org. Chem. 1999, 64, 6554.
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76. Diaz A., Siro J.G., Garcia-Navio J.L., Vaquero J.J., Alvarez-Builla J. Synthesis. 1997;559.