Diastereoselective synthesis of all four isomers of 3-(4-chlorophenyl)glutamic acid: Identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons

Journal of Medicinal Chemistry

Volumn 39, Issue 24, 1996, Pages 4738-4743

  Jane, David E ^a   Chalmers, David J ^c   Howard, Judith A K ^b   Kilpatrick, Ian C ^a   Sunter, David C ^c   Thompson, Gareth A ^a   Udvarhelyi, Peter M ^a   Wilson, Claire ^b   Watkins, Jeffrey C ^a  

^a Dept Anat Sch Med Sci U   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c Langford House   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 PYRROLIDINEDICARBOXYLIC ACID; 3 (4 CHLOROPHENYL)GLUTAMIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; HOMOCYSTEIC ACID; NEUROTRANSMITTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SYNTHESIS; ISOMERISM; MOTOR NERVE CONDUCTION; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; RAT; STEREOCHEMISTRY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; GLUTAMATES; GLUTAMIC ACID; HOMOCYSTEINE; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEURONS; NEUROTRANSMITTER AGENTS; RATS; SPINAL CORD; STEREOISOMERISM;

EID: 0030478029     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960382c     Document Type: Article

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