Hemoglobin Solutions and Tissue Oxygenation

Journal of Veterinary Internal Medicine

Volumn 17, Issue 2, 2003, Pages 127-135

  Muir, William W ^a   Wellman, Maxey L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Functional capillary density; Microcirculation; Nitric oxide; Oxygen delivery; Viscosity

Indexed keywords

HEMOGLOBIN; BLOOD SUBSTITUTE; NITRIC OXIDE; OXYGEN;

AUTOREGULATION; BODY TEMPERATURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENCAPSULATION; ERYTHROCYTE; MICROCIRCULATION; MOLECULAR WEIGHT; NONHUMAN; OXYGEN CONSUMPTION; REVIEW; TISSUE OXYGENATION; ANIMAL; BLOOD; BLOOD PRESSURE; METABOLISM; SOLUTION AND SOLUBILITY;

ANIMALS; BLOOD PRESSURE; BLOOD SUBSTITUTES; HEMOGLOBINS; MICROCIRCULATION; NITRIC OXIDE; OXYGEN; OXYGEN CONSUMPTION; SOLUTIONS;

EID: 0038317943     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2003)017<0127:HSATO>2.3.CO;2     Document Type: Review

References (135)

1. 2/kg/min. Anesthesiology 2000;92:407-413.
2. Siegel JH. Through a glass darkly: The lung as a window to monitor oxygen consumption, energy metabolism, and severity of critical illness. Clin Chem 1990;36(8B):1585-1593.
3. Hsia CC. Respiratory function of hemoglobin. N Engl J Med 1998;338:239-247.
4. Amberson WR, Jennings JJ, Rhode CM. Clinical experience with hemoglobin-saline solutions. J Appl Physiol 1949;1:469-489.
5. Braun S, Wiess FR, Keller A, et al. Evaluation of the renal toxicity of heme proteins and their derivatives: A role in the genesis of acute tubular necrosis. J Exp Med 1969;129:909-924.
6. Vandergriff KD, Winslow RM. A theoretical analysis of oxygen transport: A new strategy for the design of hemoglobin-based red cell substitutes. In: Winslow RM, Vandergriff KD, Intaglieta M, eds. Blood Substitutes: Physiological Basis of Efficacy. Boston, MA: Birkhauser; 1995:143-154.
7. Tsai AG, Intaglietta M. High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger. Biorheology 2001;38:229-237.
8. Birchard GF. Optimal hematocrit: Theory, regulation and implications. Am Zool 1997;37:65-72.
9. 2 carrier. J Cereb Blood Flow Metab 1994;14:871-876.
10. Granger HJ, Sheperd AP Jr. Intrinsic microvascular control of tissue oxygen delivery. Microvasc Res 1973;5:49-72.
11. Shepherd AP, Granger HJ, Smith EE, et al. Local control of tissue oxygen delivery and its contribution to the regulation of cardiac output. Am J Physiol 1973;225:747-755.
12. Stowell CP, Levin J, Speiss BD, et al. Progress in the development of RBC substitutes. Transfusion 2001;41:287-299.
13. Fronticelli C, Bucci E, Orth C. Solvent regulation of oxygen affinity in hemoglobin. Sensitivity of bovine hemoglobin to chloride ions. J Biol Chem 1984;259:10841-10844.
14. Breepoel PM, Dreuzer F, Hazevoet M. Interactions of organic phosphates with bovine hemoglobin. I. Oxylabile and phosphatelabile proton binding. Pflugers Arch 1981;389:219-225.
15. Diller TE, Pattantyus A, Gritts WC. Augmentation, facilitation of oxygen transfer in flowing hemoglobin solution. Adv Exp Med Biol 1984;180:545-550.
16. Page T, Light WR, McKay CB, et al. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. Microvasc Res 1998;55:54-64.
17. Horn EP, Standl T, Wilhelm S, et al. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery 1997;121(4):411-418.
18. Harringer W, Hodakoski GT, Svizzere T, et al. Acute effects of massive transfusion of a bovine hemoglobin blood substitute in a canine model of hemorrhagic shock. Eur J Cardiothoac Surg 1992;6:649-654.
19. Standl T, Horn P, Wilhelm S, et al. Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs. Can J Anaesth 1996;43(7):714-723.
20. Hamilton RG, Kelly N, Gawryl MMS, et al. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion 2001;41:219-225.
21. Hughes GS, Antal EJ, Locker PK, et al. Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med 1996;24(5):756-764.
22. Hughs GS Jr, Yancey EP, Albrecht R, et al. Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin Pharmacol Ther 1995;58:434-443.
23. Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol 1999;21:427-433.
24. Manning JE, Katx LM, Brownstein MR, et al. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Shock 2000;13:152-159.
25. McMeil JD, Smith DL, Jenkins DH, et al. Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma 2001;50:1063-1075.
26. Creteur J, Sibbald W, Vincent J-L. Hemoglobin solutions - Not just red blood cell substitutes. Crit Care Med 2000;28:3025-3034.
27. Hess JR. Blood substitutes. Semin Hematol 1996;33:369-373.
28. Rohlfs RJ, Bruner E, Chiu A, et al. Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide. J Biol Chem 1998;273(20):12128-12134.
29. Kasper S-F, Walter M, Grune F, et al. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Cardiovasc Anesth 1996;83:921-927.
30. Krieter H, Hagen G, Waschke KF, et al. Isovolemic hemodilution with a bovine hemoglobin-based oxygen carrier: Effects on hemodynamics and oxygen transport in comparison with a nonoxygen-carrying substitute. J Cardiothorac Vasc Anesth 1997;11:3-9.
31. Hess JR, MacDonald VW, Brinkley WW. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993;74:1769-1778.
32. Hess JR, MacDonald VW, Gomez CS, et al. Increased vascular resistance with hemoglobin-based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol 1994;22:361-372.
33. Winslow RM, Gonzales A, Gonzles ML, et al. Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model. J Appl Physiol 1998;85:993-1003.
34. Gulati A, Rabello S. Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin. J Lab Clin Med 1994;124:125-133.
35. Gulati A, Sharma AC, Singh G. Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin. Crit Care Med 1996;24:137-147.
36. 2 carriers after 2 h of hemorrhagic shock in conscious hamsters. Am J Physiol 1997;272:H525-H537.
37. Faivre-Fiorina B, Caron A, Fassot C, et al. Presence of hemoglobin inside aortic endothelial cells after cell-free hemoglobin administration in guinea pigs. Am J Physiol 1999;45:H766-H770.
38. Intaglietta M. Microcirculatory basis for the design of artificial blood. Microcirculation 1999;6:247-258.
39. Doyle MP, Apostol I, Kerwin BA. Gluteraldehyde modification of recombinant human hemoglobin alters its hemodynamic properties. J Biol Chem 1999;274:2583-2591.
40. Menu P, Bleeker W, Longrois D, et al. In vivo effects of Hb solutions on blood viscosity and rheologic behavior of RBCs: Comparison with clinically used volume expanders. Transfusion 2000;40:1095-1103.
41. 2 carriers determine constriction of resistance arteries and hypertension. Am J Physiol 2000;279:H908-H915.
42. Caron A, Malfiatti E, Aguejouf O, et al. Vasoconstrictive response of rat mesenteric arterioles following infusion of cross-linked, polymerized, and conjugated hemoglobin solutions. Artif Cells Blood Substit Biotechnol 2001;29:19-30.
43. Alayash AI. Hemoglobin-based blood substitute: Oxygen carriers, pressor agents, or oxidants? Nat Biotechnol 1999;17:545-549.
44. Stamler JS, Meissner G. Physiology of nitric oxide in skeletal muscle. Physiol Rev 2001;81(1):209-237.
45. Stamler JS. Nitric oxide in the cardiovascular system. Review in depth. In: Loscalzo J, Vita JA, eds. Nitric Oxide in the Cardiovascular System. Baltimore, MD: Williams & Wilkins; 1999:273.
46. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-131.
47. Dinh-Xuan AT, Higenbottam TW, Clelland CA, et al. Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease. N Engl J Med 1991;324:1539-1547.
48. Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995;333:214-221.
49. Quyyumi AA, Dakak N, Andrews NP, et al. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary athersclerosis. J Clin Invest 1995;95:1747-1755.
50. Lieberman EH, Gerhard MD, Uehata A, et al. Flow induced vasodilation of the human brachial artery is impaired in patients < 40 years of age with coronary artery disease. Am J Cardiol 1996;78:1210-1214.
51. Quyyumi AA, Dakak N, Mulcahy D, et al. Nitric oxide activity in the athersclerotic human coronary circulation. J Am Coll Cardiol 1997;29:308-317.
52. Forte P, Copland M, Smith LM, et al. Basal nitric oxide synthesis in essential hypertension. Lancet 1997;349:837-842.
53. Archer SL, Djaballah K, Humbert M, et al. Nitric oxide deficiency in fenfluramine and dexfenfluramine induced pulmonary hypertension. Am J Respir Crit Care Med 1998;158:1061-1067.
54. Quyyumi AA. Endothelial function in health and disease: New insights into the genesis of cardiovascular disease. Am J Med 1998;105:32S-39S.
55. Amal JF, Dinh-Xuan AT, Pueyo M, et al. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 1999;55:1078-1087.
56. Wright CE, Rees DD, Moncada S. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992;26:48-57.
57. Hata JS, Dellinger RP. Nitric oxide inhibition in the treatment of septic shock. Crit Care Med 1995;23:45-79.
58. Szabo C, Mitchell JA, Thiemermann C, et al. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993;108:786-792.
59. Vincent JL, Zhang H, Szabo C, et al. Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 2000;161:1781-1785.
60. Nathan C, Xie QW. Nitric oxide synthases: Roles, tolls, and controls. Cell 1994;78:915-918.
61. Dweik RA, Laskowski D, Abu-Soud HM, et al. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. J Clin Invest 1998;101:660-666.
62. Stamler JS, Toone EJ, Lipton SA, et al. (S) NO signals: Translocation, regulation, and a consensus motif. Neuron 1997;18:691-696.
63. Hausladen A, Stamler JS. Nitrosative stress. Methods Enzymol 1999;300:389-395.
64. Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-376.
65. Schmidt HH, Hofmann SM, Walter U. The nitric oxide and cGMP signal transduction system: Regulation and mechanism of action. Biochim Biophys Acta 1993;1178:153-175.
66. Gladwin MT, Shelhamer JH, Scheeler AN, et al. Role of circulating nitrite and S-nitrohemoglobin in the regulation of regional blood flow in humans. Proc Natl Acad Sci USA 2000;97:11482-11487.
67. Lui X, Miller M, Joshi MS, et al. Diffusion-limited reaction of free nitric oxide with erythrocytes. J Biol Chem 1998,273(30):18709-18713.
68. 2. Proc Natl Acad Sci USA 2001;98(1):355-360.
69. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-526.
70. Moncada S, Higgs A. The L-arginin-nitric oxide pathway. N Engl J Med 1993;329:2002-2012.
71. Rioux F, Drapeau G, Marceau F. Recombinant human hemoglobin (rHb1.1) selectively inhibits vasorelaxation elicited by nitric oxide donors in rabbit isolated aortic rings. J Cardiovasc Pharmacol 1995;25:587-594.
72. Thompson A, McGarry AE, Valeri CR, et al. Stroma-free hemoglobin increases blood pressure and GFR in the hypotensive rat: Role of nitric oxide. J Appl Physiol 1994;77:2348-2354.
73. Sharma AC, Singh G, Gulati A. Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats. Am J Physiol 1995;269:H1379-H1388.
74. Ronney MW, Hirsch LJ, Mathru M. Hemodilution of oxyhemoglobin: Mechanism of oxygen delivery and its superaugmentation with a nitric oxide donor (sodium nitroprusside). Anesthesiology 1993;79:60-72.
75. Ulatowski JA, NishikawaT, Mathesion-Urbaitis B, et al. Regional blood flow alterations after bovine fumaryl ββ-cross-linked hemoglobin transfusion and nitric oxide synthase inhibition. Crit Care Med 1996;24:558-565.
76. Rudolph AS, Sulpizio A, Heible P, et al. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. J Appl Physiol 1997;82:1826-1835.
77. Zuck TF, Riess JG. Current status of injectable oxygen carriers. Crit Rev Clin Lab Sci 1994;31:295-324.
78. Nishide H, Chen XS, Tsudchida E. Facilitated oxygen transport with modified and encapsulated hemoglobins across nonflowing solution membranes. Artif Cells Blood Immobil Biotechnol 1997;25:335-346.
79. Doherty DH, Doyle MP, Curry SR, et al. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol 1998;16:672-676.
80. Botzlar A, Nolte D, Messmer K. Effects of ultra-purified polymerized bovine hemoglobin on the microcirculation of striated skin muscle in the hamster. Eur J Med Res 1995;1:471-478.
81. Mouren S, Souktani R, Beaussier L, et al. Mechanisms of coronary vasoconstriction induced by high arterial oxygen tension. Am J Physiol 1997;272:H67-H75.
82. Sasaki N, Sato T, Ohler A, et al. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation 2000;101:439-448.
83. Hess JR, MacDonald VW, Brinkley WW. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993;74:1769-1778.
84. Kock T, Duncker HP, Hleere A, et al. Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. Shock 1994;1:146-152.
85. Reeve HL, Michelakis E, Nelson DP, et al. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 2001;90:2249-2256.
86. Michelakis ED, Weir EK, Wu X, et al. Potassium channels regulate tone in rat pulmonary veins. J Appl Physiol 2001;280:L1138-L1147.
87. Hughs GS, DeSmith VL, Locker PK, et al. Phlebotomy of 500 or 750 mL of whole blood followed by isovolemic hemodilution or autologous transfusion yields similar hemodynamic, hematologic and biochemical effects. J Lab Clin Med 1994;123:290-298.
88. Driessen B, Jahr JS, Lurie F, et al. Effects of haemoglobin-based oxygen carrier hemoglobin glutamer-201 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Br J Anaesth 2001;86:683-692.
89. Driessen B, Jahr JS, Lurie F, et al. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia. J Vet Pharmacol Ther 2001;24:61-71.
90. Cheug ATW, Jahr JS, Driessen B, et al. The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: A noninvasive computer-assisted intravital microscopy study. Anesth Analg 2001;93:832-838.
91. Bosman RJ, Minten J, Lu HR, et al. Free polymerized hemoglobin versus hydroxyethyl starch in resuscitation of hypovolemic dogs. Anesth Analg 1992;75:811-817.
92. 2 carriers after 2h of hemorrhagic shock in conscious hamsters. Am J Physiol 1997;273:H525-H537.
93. Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol 1999;21(6):427-433.
94. LaMuraglia GM, O'Hara PJ, Baker WH, et al. The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution. J Vasc Surg 2000;31:299-308.
95. Manning JE, Katz LM, Brownstein MR, et al. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Shock 2000;13(2):152-159.
96. Manley G, Morabito D, Hemphill J. Effect of small volume resuscitation with hemoglobin substitute HBOC-201 on brain tissue oxygenation following experimental hemorrhagic shock. J Trauma 2000;48(1):195.
97. McNeil JD, Smith DL, Jenkins DH, et al. Hypotensive resuscitation using polymerized bovine hemoglobin-based oxygen carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma 2001;50:1063-1075.
98. Paradis NA, Rose MI, Gawryl MS. Selective aortic perfusion and oxygenation: An effective adjunct external chest compression-based cardiopulmonary resuscitation. J Am Coll Card 1994;23:497-504.
99. Paradis NA. Dose-response relationship between aortic infusions of polymerized bovine hemoglobin and return of circulation in a canine model of ventricular fibrillation and advanced cardiac life support. Crit Care Med 1997;25:476-483.
100. Heneka MT, Loschman PA, Osswald H. Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. J Clin Invest 1997;99(1):47-54.
101. Hodakowski GT, Page RD, Harringer W, et al. Ultra-pure polymerized bovine hemoglobin blood substitute: Effects on the coronary circulation. Biomaterials 1992;20:669-672.
102. Strange MB, Caswell JE, Jones SP, et al. Evaluation of a hemoglobin based blood substitute in a canine model of myocardial ischemia-reperfusion. FASEB H 2000;April 15-18:1.1-565.7 (abstract).
103. Manley G, Morabito D, Hemphill J, et al. Effect of small-volume resuscitation with hemoglobin substitute HBOC-201 on brain tissue oxygenation following experimental hemorrhagic shock. J Trauma 2000;48:195 (abstract).
104. Niquille M, Touzet M, Leblanc I, et al. Reversal of intraoperative myocardial ischemia with a hemoglobin-based oxygen carrier. Anesthesiology 2000;92:882-885.
105. Menezes J, Hierholzer C, Watkins SC, et al. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. Am J Physiol 1999;40:G144-G151.
106. Rentko VT, Wohl WR, Murtaugh R, et al. Clinical trial of hemoglobin based oxygen carrier (HBOC) fluid in the treatment of anemia. J Vet Intern Med 1996;10:177 (abstract).
107. Giger U, Rentko VT. Alternatives to blood transfusions. 16th American College of Veterinary Internal Medicine Forum, San Diego, CA, May 22-25, 1998:430-431.
108. Day TK. Oxyglobin therapy for patients with hemolytic anemia. Compend Cont Educ Pract Vet 1999;21:S6-S10.
109. Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999). J Am Vet Assoc 2001;15:543-546.
110. Day TK, Macintire DK, Murtaugh RJ, et al. Differing opinions on the treatment of immune-mediated hemolytic anemia. J Am Vet Med Assoc 2001;218:1414-1415.
111. Skoutelis AT, Kaleridis V, Athanassiou GM, et al. Neutrophil deformability in patients with sepsis, septic shock, and adult respiratory distress syndrome. Crit Care Med 2000;28:2355-2359.
112. Tremblay LN, Rizoli SB, Brenneman FD. Advances in fluid resuscitation of hemorrhagic shock. Can J Surg 2001;44:172-178.
113. Norris CR, Griffey SM, Samii VF. Pulmonary thromboembolism in cats: 29 cases (1987-1997). J Am Vet Med Assoc 1999;215:1650-1654.
114. Johnson LR, Lappin MR, Baker DC. Pulmonary thromboembolism in 29 dogs: 1985-1995. J Vet Intern Med 1999;13:338-345.
115. Sunder-Plassmann G, Patruta SI, Horl WH. Pathobiology of the role of iron in infection. Am J Kidney Dis 1999;34:S25-S29.
116. Bullen J, Griffiths E, Rogers H, et al. Sepsis: The critical role of iron. Microbes Infect 2000;2:409-415.
117. Roth SD, Yoshida M, Levin J. Hemoglobin increases mortality from bacterial endotoxin. Infect Immun 1997;65:1258-1266.
118. Langrmans JAM, vanVuren-van der Hulsst MEB, Bleeker WK. Safety evaluation of a polymerized hemoglobin solution in a murine infection model. J Lab Clin Med 1996;127:428-434.
119. Vallet B, Tavernier B, Lund N. Assessment of tissue oxygenation in the critically-ill. Eur J Anaesth 2000;17:221-229.
120. Brazzi L, Gattinoni L. Does optimizing oxygen transport improve outcome in intensive care patients? Br J Anaesth 1998;81(Suppl 1):46-49.
121. Bishop MH, Shoemaker WC, Appel PL, et al. Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 1995;38:780-787.
122. Gattinono L, Brazzi L, Pelosi P, et al. A trial of goal-orientated hemodynamic therapy in critically ill patients. N Engl J Med 1995;333:1025-1032.
123. Shoemaker WC, Appel AL, Kram HB, et al. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988;94(6):1176-1186.
124. Fleming A, Bishop M, Shoemaker W, et al. Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg 1992;127:1175-1181.
125. Boyd O, Grounds RM, Bennet ED. A randomized clinical trail of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993;270(22):2699-2707.
126. Russel JA, Phang PT. The oxygen delivery/consumption controversy. Am J Crit Care Med 1994;149:533-537.
127. Gasman JD, Ruoss SJ, Fishman RS, et al. Hazards with both determining and utilizing oxygen consumption measurements in the management of critically ill patients. Crit Care Med 1996;24:6-9.
128. Russel JA. Adding fuel to the fire - The supranormal oxygen delivery trials controversy. Crit Care Med 1998;26:981-983.
129. Velmahos GC, Demetriades D, Shoemaker WC, et al. Endpoints of resuscitation of critically injured patients: Normal or supernormal. Ann Surg 2000;232:409-418.
130. Bakker J, Caffernils M, Leon M, et al. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991;99(4):956-962.
131. van der Hoeven M, Maertzdorf WJ, Blanco CE. Relationship between mixed venous oxygen saturation and markers of tissue oxygenation in progressive hypoxic hypoxia and in isovolemic anemic hypoxia in 8- to 12-day-old piglets. Crit Care Med 1999;27:1885-1892.
132. Smith I, Kumar P, Molloy S, et al. Base excess and lactate as prognostic indicators for patients admitted to intensive care. Intensive Care Med 2001;27:74-83.
133. Lebuffe G, Robin E, Vallet B. Gastric tonometry. Intensive Care Med 2001;27:317-319.
134. Vallet B, Chopin C. The supernormal oxygen delivery trials controversy. Dobutamine in Sepsis Study Group. Crit Care Med 2000;28:1257-1258.
135. Ball JA, Rhodes A, Bennett ED. Prognostic factors in intensive care. Eur J Intern Med 2001;2:334-343.