Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans

Critical Care Medicine

Volumn 24, Issue 5, 1996, Pages 756-764

  Hughes Jr , George S ^a,b   Antal, Edward J ^b   Locker, Paula K ^a   Francom, Steven F ^a   Adams, Wade J ^a   Jacobs Jr , Edward E ^c  

^a Pharmacia and Upjohn ^*  (United States)

^b PFIZER INC   (United States)

^c Biopure Corporation   (United States)

Author keywords

critical illness; hemoglobin; hemorrhage; humans; pharmacokinetics; pharmacology; physiology

Indexed keywords

BUFFER; GLUTARALDEHYDE; HEMOGLOBIN; METHEMOGLOBIN; PLASMA SUBSTITUTE; POLYMER; RINGER LACTATE SOLUTION;

ADULT; ARTICLE; BLEEDING; BLOOD SUBSTITUTION; BLOOD VOLUME; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG SAFETY; HALF LIFE TIME; HEMODILUTION; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PHLEBOTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADOLESCENT; ADULT; BLOOD LOSS, SURGICAL; BLOOD SUBSTITUTES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODILUTION; HEMODYNAMIC PROCESSES; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHLEBOTOMY; POLYMERS; RESPIRATORY FUNCTION TESTS; SINGLE-BLIND METHOD;

EID: 0029888711     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199605000-00006     Document Type: Article

References (35)

1. Wiesen AR, Hospenthal DR, Byrd JC, et al: Equilibration of hemoglobin concentration after transfusion in medical inpatients not actively bleeding. Ann Intern Med 1994; 121:278-280
2. Welch HG, Meehan KR, Goodnough LT: Prudent strategies for elective red blood cell transfusion. Ann Intern Med 1992; 116:393-402
3. Audet A, Goodnough LT: Practice strategies for elective red blood cell transfusion. Ann Intern Med 1992; 116:403-406
4. Vlahakes GJ, Lee R, Jacobs EE, et al: Hemodynamic effects and oxygen transport properties of a new blood substitute in a model of massive blood replacement. J Thorac Cardiovasc Surg 1990; 100:379-388
5. Teicher BA, Schwartz GN, Sotomayor EA, et al: Oxygenation of tumors by a hemoglobin solution. J Cancer Res Clin Oncol 1993; 120:85-90
6. Breepoel PM, Kreuzer F, Hazevoet M: Interactions of organic phosphates with bovine hemoglobin. I. Oxylabile and phosphate-labile proton binding. Pflügers Arch 1981; 389:219-225
7. 2 affinity regulation; DPG, monovalent anions, and hemoglobin concentration. J Appl Physiol 1977; 43:632-642
8. Bunn HF: Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins. Science 1971; 172:1049-1050
9. Rapoport S, Guest GM: Distribution of acid-soluble phosphorus in the blood cells of various vertebrates. J Biol Chem 1941; 138:269-282
10. Vandegriff KD, Winslow RM: A theoretical analysis of oxygen transport: A new strategy for the design of hemoglobin-based red cell substitutes. In: Blood Substitutes - Physiological Basis of Efficacy. Winslow RM, Vandegriff KD, Intaglietta M (Eds). Boston, MA, Birkhauser, 1995, pp 143-154
11. Hughes GS, DeSmith VL, Locker PK, et al: Phlebotomy of 500 or 750 milliliters of whole blood followed by isovolemic hemodilution or autologous transfusion yields similar hemodynamic, hematologic and biochemical effects. J Lab Clin Med 1994; 123:290-298
12. Crapo RO, Gardner RM, Clausen JL, et al: Single breath carbon monoxide diffusing capacity (transfer factor): Recommendations for a standard technique. Am Rev Respir Dis 1987; 136: 1299-1307
13. Ayers LN, Ginsberg ML, Fein J, et al: Diffusing capacity, specific diffusing capacity and interpretation of diffusion effects. West J Med 1975; 123:255-264
14. Morgan GE, Mikhail MS: Clinical Anesthesiology. Norwalk, CT, Appleton and Lange, 1992, pp 362-394
15. Shargel L, Yu ABC: Applied Biopharmaceutics and Pharmacokinetics. Second Edition. Norwalk, CT, Appleton-Century-Crofts, 1985
16. Savitsky JP, Doczi J, Black J, et al: A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther 1978; 23:73-80
17. Homer LD, Weathersby PK, Kiesow LA: Oxygen gradients between red blood cells in the microcirculation. Microvasc Res 1981; 22:308-323
18. Coin JT, Olson JS: The rate of oxygen uptake by human red blood cells. J Biol Chem 1979; 254:1178-1190
19. Vandegriff KD, Olson JS: A quantitative description in three dimensions of oxygen uptake by human red blood cells. Biophys J 1984; 45:825-835
20. 50. J Appl Physiol 1987; 62:1801-1807
21. Hughes G, Jacobs E, Yancey B, et al: Hemoglobin-based oxygen carrier preserves oxygen delivery and exercise capacity in humans. Abstr. Crit Care Med 1995; 23:A86
22. Toy PTCY, Kaplan EB, McVay PA, et al: Blood loss and replacement in total hip arthroplasty: A multicenter study. Transfusion 1992; 32:63-67
23. Goodnough LT, Riddell J IVth, Kursh E, et al: Utilization and efficacy of autologous blood predeposit in radical prostatectomy with lymphadenectomy: Implications for blood conservation and physician education programs. Urology 1992; 40:201-205
24. Baldwin ML, Kurtz SR: Transfusion Practice in Cardiac Surgery. Arlington, VA, American Association of Blood Banks, 1991
25. Dalton JM, Gore DC, Makhoul RG, et al: Decreased splanchnic perfusion measured by duplex ultrasound in humans undergoing small volume hemorrhage. Crit Care Med 1995; 23: 491-497
26. Hernan LJ, Fuhrman BP, Papo MC, et al: Cardiorespiratory effects of perfluorocarbon-associated gas exchange at reduced oxygen concentrations. Crit Care Med 1995; 23:553-559
27. Shoemaker WC, Appel PL, Kram HB, et al: Comparison of two monitoring methods (central venous pressure versus pulmonary artery catheter) and two protocols as therapeutic goals (normal values versus values of survivors) in a prospective randomized clinical trial of critically ill surgical patients. Crit Care Med 1985; 13:304
28. Tremper KK, Barker SJ: Pulse oximetry. Anesthesiology 1989; 70:98-108
29. Stehling L, Zauder HL: Acute normovolemic hemodilution. Transfusion 1991; 31:857-868
30. Rooney MW, Hirsch LJ, Mathru M: Hemodilution with oxyhemoglobin. Anesthesiology 1993; 79:60-72
31. Brady AJB, Warren JB, Poole-Wilson PA, et al: Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol 1993; 265(Heart Circ Physiol 34): H176-H182
32. Schulz R, Triggle CR: Role of NO in vascular smooth muscle and cardiac muscle function. Trends in Pharmaceutical Sciences 1994; 15:255-259
33. Hodakowski GT, Page RD, Harringer W, et al: Greater maximal myocardial oxygen delivery after hemodilution with polymerized bovine hemoglobin blood substitute. Surg Forum 1990; 41: 304-306
34. Lowenstein CJ, Dinerman JL, Snyder SH: Nitric oxide: A physiologic messenger. Ann Intern Med 1994; 120: 227-237
35. Tsai AG, Kerger H, Intaglietta M: Microcirculatory consequences of blood substitution with αα-hemoglobin. In: Blood Substitutes - Physiological Basis for Efficacy. Winslow RM, Vandegriff KD, Intaglietta M (Eds). Boston, MA, Birkhäuser, 1995, pp 155-174