The incorporation of an Ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: In vitro and in vivo feasibility studies

Human Gene Therapy

Volumn 14, Issue 9, 2003, Pages 907-922

  Burton, Denise Y ^a   Song, Cunxian ^a   Fishbein, Ilia ^a   Hazelwood, Senator ^a   Li, Quanyi ^a   Defelice, Suzanne ^a   Connolly, Jeanne M ^a   Perlstein, Itay ^a   Coulter, Douglas A ^b   Levy, Robert J ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; DNA; DNA ANTIBODY; GREEN FLUORESCENT PROTEIN; ION CHANNEL; LIPID; PLASMID VECTOR; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; DNA TRANSFECTION; DNA VECTOR; ELECTROPHYSIOLOGY; GENE; GENE HMIRP1; GENE LOCATION; GENE MUTATION; GENE OVEREXPRESSION; GENE Q9E HMIRP1; GENE THERAPY; GENETIC PREDISPOSITION; HEART ARRHYTHMIA; HEART REPOLARIZATION; HUMAN; HUMAN CELL; ION CHANNEL GENE; LONG QT SYNDROME; MISSENSE MUTATION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE SPECIFIC GENE THERAPY; SWINE; WESTERN BLOTTING;

ANIMALS; CELL LINE; CELL MEMBRANE; FEASIBILITY STUDIES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE THERAPY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MALE; MUTATION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PLASMIDS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROMANO-WARD SYNDROME; SWINE; TRANSFECTION; TRANSGENES;

ANIMALIA; SUS SCROFA; TOR;

EID: 0038280062     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403765701196     Document Type: Article

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