Inhibition of CCL11, CCL24, and CCL26-induced degranulation in HL-60 eosinophilic cells by specific inhibitors of MEK1/MEK2, p38 MAP kinase, and PI 3-kinase

Immunopharmacology and Immunotoxicology

Volumn 25, Issue 2, 2003, Pages 145-157

  Badewa, A P ^a   Heiman, A S ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

EOS (eosinophils) HL60 eosinophils; Eosinophil peroxidase (EPO); Eotaxin (CCL11); Eotaxin 2 (CCL24); Eotaxin 3 (CCL26); MEK1 MEK2; p38 MAPK; PI 3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; EOSINOPHIL PEROXIDASE; EOTAXIN; EOTAXIN 2; EOTAXIN 3; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGY; ARTICLE; CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; DEGRANULATION; ENZYME INHIBITION; EOSINOPHIL; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BUTADIENES; CELL DEGRANULATION; CHEMOKINES, CC; CHEMOTACTIC FACTORS, EOSINOPHIL; ENZYME INHIBITORS; EOSINOPHIL PEROXIDASE; EOSINOPHILS; HL-60 CELLS; HUMANS; IMIDAZOLES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIDINES;

EID: 0038246421     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.1081/IPH-120020466     Document Type: Article

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