Detection of mRNA for eotaxin-2 and eotaxin-3 in human dermal fibroblasts and their distinct activation profile on human eosinophils

Journal of Investigative Dermatology

Volumn 116, Issue 4, 2001, Pages 498-505

  Dulkys, Yasmin ^a   Schramm, Georg ^a   Kimmig, Daniela ^a   Knoöß, Sabine ^a   Weyergraf, Ansgar ^a   Kapp, Alexander ^a   Elsner, Jörn ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chemokine; Chemokine receptor; Eosinophils; Eotaxin; Fibroblasts

Indexed keywords

ACTIN; CALCIUM ION; CHEMOKINE RECEPTOR CCR3; EOTAXIN; EOTAXIN 2; EOTAXIN 3; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4; RANTES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DNA SEQUENCE; EOSINOPHIL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SKIN FIBROBLAST;

EID: 0035049905     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01299.x     Document Type: Article

References (37)

1. Human dermal fibroblasts express eotaxin: Molecular cloning, mRNA expression, and identification of eotaxin sequence variants
2. Activation of human eosinophils by chemokines
3. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils
4. Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization
5. Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils
6. Differential activation of CC chemokine receptors by AOP-RANTES
7. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR 3, and acts like eotaxin on human eosinophil and basophil leukocytes
8. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
9. 2+ indicators with greatly improved fluorescence properties
10. Chemotactic peptide modulation of actin assembly and locomotion in neutrophils
11. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia
12. Eotaxin. A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
13. Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils: Differential chemokine expression in tissues involved by Hodgkin's disease: Direct correlation of eotaxin expression and tissue eosinophilia
14. Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3
15. Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: A role for transforming growth factor beta (TGF-beta)
16. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes
17. Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23
18. Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils
19. Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a
20. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
21. Chemokine receptors - Future therapeutic targets for HIV?
22. The role of chemokines in cutaneous allergic inflammation
23. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils
24. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines
25. Detection of the chemokine RANTES in cytokine-stimulated human dermal fibroblasts
26. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts
27. Differential chemokine expression in tissues involved by Hodgkin's disease: Direct correlation of eotaxin expression and tissue eosinophilia
28. The chemokine information source: Identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases
29. Chemokine receptors and their role in leukocyte activation
30. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils
31. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
32. Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma): Inhibition by immunoglobulin a complexes
33. Human eosinophils express messenger RNA encoding RANTES and store and release biologically active RANTES protein
34. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics
35. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES)
36. IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma
37. CC chemokine receptor-3 undergoes prolonged ligand-induced internalization