Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short-term fasting

Journal of Endocrinological Investigation

Volumn 26, Issue 4, 2003, Pages 333-340

  Micić, Dragan ^a   Sumarac Dumanovic M ^a   Macut, Dj ^a   Kendereski A ^a   Zoric S ^a   Popovic V ^a   Cvijovic G ^a   Dieguez, C ^b   Casanueva, F F ^b  

^a Inst Endocrino Diabet/Dis Metab   (Yugoslavia)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Fasting; GHRH; GHRP 6; Growth factor 1; Growth hormone; Insulin; Insulin like; Leptin; Polycystic ovary syndrome

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING HEXAPEPTIDE; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HUMAN GROWTH HORMONE; INSULIN; LEPTIN; OLIGOPEPTIDE; SERMORELIN; SOMATOMEDIN C; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; FEMALE; HOMEOSTASIS; HORMONAL REGULATION; HORMONE RESPONSE; HORMONE SENSITIVITY; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; METABOLISM; OBESITY; OVARY POLYCYSTIC DISEASE; PHYSIOLOGY; PROTEIN BLOOD LEVEL; STIMULUS;

EID: 0038168672     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345181     Document Type: Article

References (44)

1. Morales A.J. Role of growth hormone in polycystic ovarian syndrome. Semin. Reprod. Endocrinol. 1977, 15: 177-182.
2. Franks S. Growth hormone and ovarian function. Bailliere's Clin. Endocrinol. Metab. 1998, 12: 331-340.
3. Kaltsas T., Pontikides N., Krassas G.E., Seferiadis K., Lolis D., Messinis I.E. Growth hormone response to thyrotrophin releasing hormone in women with polycystic ovarian syndrome. Hum. Reprod. 1999, 14: 2704-2708.
4. Maccario M., Tassone F., Grottoli S., Rossetto R., Gauna C., Ghigo E. Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity. Ann. Endocrinol. 2002, 63: 140-144.
5. Villa P., Soranna L., Mancini A., et al. Effect of feeding on growth hormone response to growth hormone-releasing hormone in polycystic ovarian syndrome: Relation with body weight and hyperinsulinism. Hum. Reprod. 2001, 16: 430-434.
6. Micić D., Kendereski A., Popović V., et al. Growth hormone response to GHRH, GHRP-6 and GHRH+GHRP-6 in patients with polycystic ovary syndrome. Clin. Endocrinol. 1996, 45: 385-390.
7. Penalva A., Gaztambide S., Vazquez J.A., Dieguez C., Casanueva F.F. Role of cholinergic muscarinic pathways on the free fatty acid inhibition of GH responses to GHRH in normal men. Clin. Endocrinol. 1990, 33: 171-176.
8. Melmed S. Insulin suppresses growth hormone secretion by rat pituitary cells. J. Clin. Invest. 1984, 73:1425-1433.
9. Low L.C.K. Growth hormone-releasing hormone: Clinical studies and therapeutic aspects. Neuroendocrinology 1991, 53: 37-40.
10. Ho K.Y., Veldhuis J.D., Johnson M.L., et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J. Clin. Invest. 1988, 81: 968-975.
11. Rasmussen M.H., Juul A., Kjems L.L., Skakkebaek N.E., Hilsted J. Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity. J. Clin. Endocrinol. Metab. 1995, 80: 796-801.
12. Casanueva F.F., Dieguez C. Growth hormone secretatogogues, physiological role and clinical utility. Trends Endocrinol. Metab. 1999, 10: 30-38.
13. Adams J., Polson D.W., Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J. 1986, 293: 355-359.
14. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment insulin resistance and beta-cell function from fasting glucose and insulin concentration in man. Diabetologia 1985, 28: 412-419.
15. Piaditis G.P., Kounadi T.G., Rangou D.B., et al. Dysfunction of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovarian syndrome. Clin. Endocrinol. 1995, 42: 635-640.
16. Lanzone A., Villa P., Fulhesu A.M., Pavone V., Caruso A., Mancuso S. The growth hormone response to growth hormone-releasing hormone is blunted in polycystic ovary syndrome: Relationship with obesity and hyperinsulinemia. Hum. Reprod. 1995, 10: 1653-1657.
17. Prelević G.M., Wurzburger M.I., Balint-Perić L., Ginsburg J. Twenty-four-hour serum growth hormone, insulin, C-peptide and blood glucose profiles and serum insulin-like growth factor-1 concentrations in women with polycystic ovaries. Horm. Metab. Res. 1992, 37: 125-131.
18. Garcia-Rudaz M.C., Ropelato M.G., Escobar M.E., Veldhuis J.D., Barontini M. Amplified and orderly growth hormone secretion characterizes lean adolescents with polycystic ovary syndrome. Eur. J. Endocrinol. 2002, 147: 207-216.
19. Scachi M., Pincelli A.I., Cavagnini F. Growth hormone in obesity. Int. J. Obes. Relat. Metab. Disord. 1999, 23: 260-271.
20. Cordido F., Penalva A., Dieguez C., Casanueva F.F. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: Evidence for a marker somatotroph secretory capability in obesity. J. Clin. Endocrinol. Metab. 1993, 76: 819-823.
21. Popović V., Pekić S., Simić M., et al. Physical activity or food intake prior to testing did not affect the reproducibility of GH secretion elicited by GH releasing hormone plus GH-releasing hexapeptide in normal adult subjects. Clin. Endocrinol. 2002, 56: 89-94.
22. Carlson H.E., Drenick E.J., Chopra I.J., Hershman J.M. Alterations in basal and TRH-stimulated serum levels of thyrotropin, prolactin, and thyroid hormones in starved obese men. J. Clin. Endocrinol. Metab. 1977, 45: 707-713.
23. Procopio M., Maccario M., Grottoli S., et al. Short-term fasting in obesity fails to restore the blunted GH responsiveness to GH-releasing hormone alone or combined with arginine. Clin. Endocrinol. 1995, 43: 665-669.
24. Megia A., Herranz L., Luna R., Gomez-Candela C., Pallardo F., Gonzalez-Gancedo P. Protein intake during aggressive calorie restriction in obesity determines growth hormone response to growth hormone-releasing hormone after weight loss. Clin. Endocrinol. 1993, 39: 217-220.
25. Muller A.F., Janssen J.A., Lamberts S.W., et al. Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion. Clin. Endocrinol. 2001, 55: 461-467.
26. Penalva A., Pombo M., Carballow A., Barreiro J., Casanueva F.F., Dieguez C. Influence of sex, age, and adrenergic pathways on the growth hormone response to GHRP-6. Clin. Endocrinol. 1993, 38: 87-91.
27. Leal A., Lage M., Popović V., et al. A single growth hormone (GH) determination is sufficient for the diagnosis of GH-deficiency in adult patients using the growth hormone releasing hormone plus growth hormone releasing peptide-6 test. Clin. Endocrinol. 2002, 57: 377-384.
28. Carro E., Senaris R.M., Seoane L.M., et al. Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion. Neuroendocrinology 1999, 69: 3-10.
29. Cocchi D., De Gennaro Colonna V., Bagnasco M., Bonacci D., Muller E.E. Leptin regulates GH secretion in the rat by acting on GHRH and somatostatinergic functions. J. Endocrinol. 1999, 162: 95-99.
30. Carro E., Seoane L.M., Senaris R., Casanueva F.F., Dieguez C. Leptin increases in vivo GH responses to GHRH and GH-releasing peptide-6 in food-deprived rats. Eur. J. Endocrinol. 2000; 142: 66-70.
31. Mizuno I., Okimura Y., Takahashi Y., Kaji H., Abe H., Chihara K. Leptin stimulates basal and GHRH-induced GH release from cultured rat anterior pituitary cell in vitro. Kobe J. Med. Sci. 1999, 45: 221-227.
32. Micić D., Macut Dj., Popović V., et al. Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome. Gynecol. Endocrinol. 1997, 11: 315-320.
33. Wu X., Sallinen K., Zhou S., Su Y., Pollanen P., Erkkola R. Androgen excess contributes to altered growth hormone/insulin-like growth factor-1 axis in nonobese women with polycystic ovary syndrome. Fertil. Steril. 2000, 73: 730-734.
34. Mauras N. Growth hormone and sex steroids. Interactions in puberty. Endocrinol. Metab. Clin. North. Am. 2001, 30: 529-544.
35. Ruiz E., Osorio A., Torres J.M., Ortega E. Evidence of different actions of testosterone, estradiol, FSH, and LH on the growth axis. Endocr. Res. 2001, 27: 25-33.
36. Fisker S., Norrelund H., Juul A., Skakkebaek N.E., Christiansen J.S., Jorgensen J.O. The growth hormone (GH)-insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males. Growth Horm. IGF Res. 2001, 11: 104-109.
37. Ciampelli M., Muzj G., Lenoni F., et al. Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2001, 86: 5324-5329.
38. McMahon C.D., Chapin L.T., Radcliff R.P., Lookingland K.J., Tucker H.A. GH-releasing peptide-6 overcomes refractoriness of somatotropes to GHRH after feeding. J. Endocrinol. 2001, 170: 235-241.
39. Muller A.F., Lamberts S.W., Janssen J.A., et al. Ghrelin drives GH secretion during fasting in man. Eur. J. Endocrinol. 2002, 146: 203-207.
40. Kasa-Vubu J.Z., Barkan A., Olton P., Meckmongkol T., Carlson N.E., Foster C.M. Incomplete modified fast in obese early pubertal girls leads to an increase in 24-hour growth hormone concentration and a lessening of the circadian pattern in leptin. J. Clin. Endocrinol. Metab. 2002, 87: 1885-1893.
41. Fernandez-Real J.M., Granada M.L., Ruzafa A., Casamitjana R., Ricart AW. Insulin sensitivity and secretion influence the relationship between growth hormone-binding-protein and leptin. Clin. Endocrinol. 2000, 52: 159-164.
42. Kristensen K., Pedersen S.B., Fisker S., et al. Serum leptin levels and leptin expression in growth hormone (GH)-deficient and healthy adults: Influence of GH treatment, gender, and fasting. Metabolism 1998, 47: 1514-1519.
43. Bergendahl M., Evans W.S., Pastor C., Patel A., Iranmanesh A., Veldhuis J.D. Short-term fasting suppresses leptin and (conversely) activates disorderly growth hormone secretion in midluteal phase women - A clinical research center study. J. Clin. Endocrinol. Metab. 1999, 84: 883-943.
44. Bergendahl M., Iranmanesch A., Evans W.S., Veldhuis J.D. Short-term fasting selectively supresses leptin pulse mass and 24-hour rhythmic leptin release in healthy midluteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). J. Clin. Endocrinol. Metab. 2000, 85: 207-213.