Modulation of sodium current in mammalian cells by an epilepsy-correlated β1-subunit mutation

Biochemical and Biophysical Research Communications

Volumn 291, Issue 4, 2002, Pages 1095-1101

  Tammaro, Paolo ^a   Conti, Franco ^a   Moran, Oscar ^a  

^a CNR   (Italy)

Author keywords

GEFP+; Heterologous expression; Mammalian cell; Sodium channel; 1 subunit

Indexed keywords

MEMBRANE PROTEIN; MUTANT PROTEIN; SODIUM CHANNEL;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; EMBRYO; EPILEPSY; FROG; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; KIDNEY CELL; NEUROPATHOLOGY; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM CURRENT; WILD TYPE;

ANURA; MAMMALIA;

EID: 0036291451     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6570     Document Type: Article

References (31)

1. Structure and function of voltage-gated ion channels
2. Structure, function and expression of voltage-dependent sodium channels
3. β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
4. + channel a subunit with novel gating properties
5. Primary structure and functional expression of a mammalian skeletal muscle sodium channel
6. Inactivation of cloned Na channels expressed in Xenopus oocytes
7. + channels
8. 1-subunit
9. 1-subunit from rat brain
10. 1 and type IIA α subunits of sodium channels in mammalian cell line
11. Endogenous expression of the β1A sodium channel subunit in HEK-293
12. Primary structure and functional expression of the β1 subunit of the rat brain sodium channel
13. + current conducted by the rat skeletal muscle a subunit by coexpression with α human brain β subunit
14. 1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits
15. 1-subunit
16. + channels
17. Functional association of the β1 subunit with human cardiac (hHi) and rat skeletal muscle (μ1) sodium channel α subunits expressed in Xenopus oocytes
18. + channel expression in Xenopus oocytes by β1 subunits
19. +-channels β1-subunit gene
20. + channel function in the extracellular domain of the β1 subunit
21. Skeletal muscle sodium channel is affected by an epileptogenic β1 subunit mutation
22. Rapid and efficient site-specific mutagenesis without phenotypic selection
23. A simple and efficient method for the oligonucleotide-directed mutagenesis using DNA template and phosphorotiorate-modified nucleotide
24. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
25. Na channel kinetics remains stable during perforated-patch recordings
26. Impaired slow inactivation in mutant sodium channels
27. + channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties
28. Inactivation defects produced by a myopathic II-S6 mutation of the muscle sodium channel
29. Modal gating of sodium channel mutants related with hereditary myotonies
30. Voltage-dependent regulation of modal gating in the rat SkM1 sodium channel expressed in Xenopus oocytes
31. Modal gating of sodium channels and possible physiological implications on hereditary myopathies