Action of new world scorpion venom and its neurotoxins in secretion

Toxicon

Volumn 34, Issue 11-12, 1996, Pages 1399-1411

  Fletcher, Paul L ^a   Fletcher, Maryann ^a   Fainter, Lily K ^a   Terrian, David M ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ION CHANNEL; NEUROTOXIN; PROTEIN KINASE C; SCORPION VENOM;

ACINAR CELL; ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; EXOCYTOSIS; GUINEA PIG; MALE; MEMBRANE DEPOLARIZATION; NERVE ENDING; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; SYNAPTOSOME;

ANIMALS; CALCIUM CHANNELS; CYTOSOL; GUINEA PIGS; HIPPOCAMPUS; ION CHANNEL GATING; MALE; NEUROTOXINS; PANCREAS; SCORPION VENOMS; SYNAPTOSOMES;

EID: 0030293014     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(96)00093-1     Document Type: Conference Paper

References (19)

1. Akerman, K. and Nicholls, D. G. (1981) Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane. Biochim. biophys. Acta 645, 41-48.
2. Becerril, B., Corona, M., Coronas, F, I. V., Zamudio, F., Calderon-Aranda, E. S., Fletcher, P. L. Jr, Martin, B. M. and Possani, L. D. (1996) Toxic peptides and genes encoding gamma toxin of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus. Biochem. J. 313, 753-760.
3. Brauner, T., Hulser, D. F. and Strasser, R. J. (1984) Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes. Biochim. biophys. Acta 771, 208-216.
4. + channels by a novel scorpion toxin. Nature 296, 5852, 90-91.
5. Edwardson, J. M. and Marciniak, S. J. (1995) Molecular mechanisms in exocytosis. J. membr. Biol. 146, 113-122.
6. Fletcher, P. L. Jr, Fletcher, M. D. and Possani, L. D. (1992) Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion Tityus serrulatus. Eur. J. Cell Biol. 58, 259-270.
7. Fletcher, M. D., Possani, L. D. and Fletcher, P. L. Jr (1994) Morphological studies by light and electron microscopy of pancreatic acinar cells under the effect of Tityus serrulatus venom. Cell Tissue Res. 278, 255-264.
8. Gaisano, H. Y., Sheu, L., Foskett, J. K. and Trimble, W. S. (1994) Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. J. biol. Chem. 269, 17062-17066.
9. Hille, B. (1992) Ionic Channels of Excitable Membranes, 2nd Edn. Sunderland, MA: Sinaur.
10. Possani, L. D., Martin, B. M., Fletcher, M. D. and Fletcher, P. L. Jr (1991) Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom. J. biol. Chem. 266, 3178-3185.
11. + channels blocked by α-dendrotoxin in synaptosomes. Proc. ntn. Acad. Sci. U.S.A. 91, 1475-1479.
12. + entry through tetrodotoxin-sensitive channels. Biochem. J. 304, 353-357.
13. 2+-dependent glutamate release from synaptosomes. Neurosci. Lett. 169, 90-92.
14. 2+ channels. J. Neurochem. 61, 1220-1230.
15. Sollner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P. and Rothman, J. E. (1993) SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324.
16. Stojilkovic, S. S., Izumi, S.-I. and Catt, K. J. (1988) Participation of voltage-sensitive calcium channels in pituitary hormone release. J. biol. Chem. 263, 26, 13054-13061.
17. Terrian, D. M., Johnston, D., Claiborne, B. J., Ansah-Yiadom, R., Strittmatter, W. J. and Rea, M. A. (1988) Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes. Brain Res. Bull. 21, 343-351.
18. Terrian, D. M., Damron, D. S., Dorman, R. V. and Gannon, R. L. (1989) Effects of calcium antagonists on the evoked release of dynorphin A(1-8) and availability of intraterminal calcium in rat hippocampal mossy fiber synaptosomes. Neurosci. Lett. 106, 322-327.
19. Terrian, D. M., Dorman, R. V. and Gannon, R. L. (1990) Characterization of the presynaptic calcium channels involved in glutamate exocytosis from rat hippocampal mossy fiber synaptosomes. Neurosci. Lett. 119, 211-214.