메뉴 건너뛰기




Volumn 40, Issue 3, 2003, Pages 227-236

In situ zymography: A molecular pathology technique to localize endogenous protease activity in tissue sections

Author keywords

Collagenase; Gelatinase; In situ zymography; Matrix metalloproteinases; Protease

Indexed keywords

ASPARTIC PROTEINASE; METALLOPROTEINASE; PROTEINASE; SERINE PROTEINASE;

EID: 0038148278     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.40-3-227     Document Type: Short Survey
Times cited : (54)

References (53)
  • 2
    • 85067533357 scopus 로고    scopus 로고
    • Identification of new molecular targets for the treatment of breast cancer
    • Blomme EAG, Del Piero F, Kolaja KL: Identification of new molecular targets for the treatment of breast cancer. Acta Clin Croat 41:138-144, 2002
    • (2002) Acta Clin Croat , vol.41 , pp. 138-144
    • Blomme, E.A.G.1    Del Piero, F.2    Kolaja, K.L.3
  • 3
    • 0034887285 scopus 로고    scopus 로고
    • Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat
    • Curry TE Jr, Song L, Wheeler SE: Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat. Biol Reprod 65:855-865, 2001
    • (2001) Biol Reprod , vol.65 , pp. 855-865
    • Curry Jr., T.E.1    Song, L.2    Wheeler, S.E.3
  • 4
    • 0036500250 scopus 로고    scopus 로고
    • Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion
    • Di Nezza LA, Misajon A, Zhang J, Jobling T, Quinn MA, Ostor AG, Nie G, Lopata A, Salamonsen LA: Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion. Cancer 94:1466-1475, 2002
    • (2002) Cancer , vol.94 , pp. 1466-1475
    • Di Nezza, L.A.1    Misajon, A.2    Zhang, J.3    Jobling, T.4    Quinn, M.A.5    Ostor, A.G.6    Nie, G.7    Lopata, A.8    Salamonsen, L.A.9
  • 6
    • 0035036509 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Potential therapeutic target in spinal cord injury
    • Duchossoy Y, Arnaud S, Feldblum S: Matrix metalloproteinases: potential therapeutic target in spinal cord injury. Clin Chem Lab Med 39:362-367, 2001
    • (2001) Clin Chem Lab Med , vol.39 , pp. 362-367
    • Duchossoy, Y.1    Arnaud, S.2    Feldblum, S.3
  • 7
    • 0034959474 scopus 로고    scopus 로고
    • MMP-related gelatinase activity is strongly induced in scar tissue of injured adult spinal cord and forms pathways for ingrowing neurites
    • Duchossoy Y, Horvat JC, Stettler O: MMP-related gelatinase activity is strongly induced in scar tissue of injured adult spinal cord and forms pathways for ingrowing neurites. Mol Cell Neurosci 17:945-956, 2001
    • (2001) Mol Cell Neurosci , vol.17 , pp. 945-956
    • Duchossoy, Y.1    Horvat, J.C.2    Stettler, O.3
  • 8
    • 0036178388 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: Correlation with in-situ zymography
    • Faia KL, Davis WP, Marone AJ, Foxall TL: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: correlation with in-situ zymography. Atherosclerosis 160:325-337, 2002
    • (2002) Atherosclerosis , vol.160 , pp. 325-337
    • Faia, K.L.1    Davis, W.P.2    Marone, A.J.3    Foxall, T.L.4
  • 10
    • 0033001430 scopus 로고    scopus 로고
    • In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage
    • Freemont AJ, Byers RJ, Taiwo YO, Hoyland JA: In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage. Ann Rheum Dis 58:357-365, 1999
    • (1999) Ann Rheum Dis , vol.58 , pp. 357-365
    • Freemont, A.J.1    Byers, R.J.2    Taiwo, Y.O.3    Hoyland, J.A.4
  • 12
    • 0033838376 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and related tissue inhibitors in the cyst fluids of ovarian mucinous neoplasms
    • Furuya M, Ishikura H, Kawarada Y, Ogawa Y, Sakuragi N, Fujimoto S, Yoshiki T: Expression of matrix metalloproteinases and related tissue inhibitors in the cyst fluids of ovarian mucinous neoplasms. Gynecol Oncol 78: 106-112, 2000
    • (2000) Gynecol Oncol , vol.78 , pp. 106-112
    • Furuya, M.1    Ishikura, H.2    Kawarada, Y.3    Ogawa, Y.4    Sakuragi, N.5    Fujimoto, S.6    Yoshiki, T.7
  • 13
    • 0035124046 scopus 로고    scopus 로고
    • Clarification of the active gelatinolytic sites in human ovarian neoplasms using in situ zymography
    • Furuya M, Ishikura H, Nemori R, Shibata M, Fujimoto S, Yoshiki T: Clarification of the active gelatinolytic sites in human ovarian neoplasms using in situ zymography. Hum Pathol 32:163-168, 2001
    • (2001) Hum Pathol , vol.32 , pp. 163-168
    • Furuya, M.1    Ishikura, H.2    Nemori, R.3    Shibata, M.4    Fujimoto, S.5    Yoshiki, T.6
  • 14
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94:2493-2503, 1994
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 15
    • 0029129597 scopus 로고
    • Microscopic localization of active proteases by in situ zymography: Detection of matrix metalloproteinase activity in vascular tissue
    • Galis ZS, Sukhova GK, Libby P: Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue. FASEB J 9:974-980, 1995
    • (1995) FASEB J , vol.9 , pp. 974-980
    • Galis, Z.S.1    Sukhova, G.K.2    Libby, P.3
  • 16
    • 0031771145 scopus 로고    scopus 로고
    • Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins
    • George SJ, Baker AH, Angelini GD, Newby AC: Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins. Gene Ther 5:1552-1560, 1998
    • (1998) Gene Ther , vol.5 , pp. 1552-1560
    • George, S.J.1    Baker, A.H.2    Angelini, G.D.3    Newby, A.C.4
  • 18
    • 0032502944 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein
    • George SJ, Johnson JL, Angelini GD, Newby AC, Baker AH: Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein. Hum Gene Ther 9:867-877, 1998
    • (1998) Hum Gene Ther , vol.9 , pp. 867-877
    • George, S.J.1    Johnson, J.L.2    Angelini, G.D.3    Newby, A.C.4    Baker, A.H.5
  • 19
    • 0035902584 scopus 로고    scopus 로고
    • Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms
    • Goodall S, Crowther M, Hemingway DM, Bell PR, Thompson MM: Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation 104:304-309, 2001
    • (2001) Circulation , vol.104 , pp. 304-309
    • Goodall, S.1    Crowther, M.2    Hemingway, D.M.3    Bell, P.R.4    Thompson, M.M.5
  • 20
    • 0345935809 scopus 로고
    • Collagenolytic activity in amphibian tissues: A tissue culture assay
    • Gross J, Lapiere CM: Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Sci USA 48: 1014-1022, 1962
    • (1962) Proc Natl Sci USA , vol.48 , pp. 1014-1022
    • Gross, J.1    Lapiere, C.M.2
  • 21
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100:57-70, 2000
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 22
    • 0036203856 scopus 로고    scopus 로고
    • Activity of type IV collagenases (MMP-2 and MMP-9) in primary pulmonary carcinomas: A quantitative analysis
    • Hrabec E, Strek M, Nowak D, Greger J, Suwalski M, Hrabec Z: Activity of type IV collagenases (MMP-2 and MMP-9) in primary pulmonary carcinomas: a quantitative analysis. J Cancer Res Clin Oncol 128:197-204, 2002
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 197-204
    • Hrabec, E.1    Strek, M.2    Nowak, D.3    Greger, J.4    Suwalski, M.5    Hrabec, Z.6
  • 23
    • 0034938365 scopus 로고    scopus 로고
    • Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer
    • Hrabec E, Strek M, Nowak D, Hrabec Z: Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer. Respir Med 95:1-4, 2001
    • (2001) Respir Med , vol.95 , pp. 1-4
    • Hrabec, E.1    Strek, M.2    Nowak, D.3    Hrabec, Z.4
  • 24
    • 0033884067 scopus 로고    scopus 로고
    • Inhibition of gelatinolytic activity in tumor tissues by synthetic matrix metalloproteinase inhibitor: Application of film in situ zymography
    • Ikeda M, Maekawa R, Tanaka H, Matsumoto M, Takeda Y, Tamura Y, Nemori R, Yoshioka T: Inhibition of gelatinolytic activity in tumor tissues by synthetic matrix metalloproteinase inhibitor: application of film in situ zymography. Clin Cancer Res 6:3290-3296, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 3290-3296
    • Ikeda, M.1    Maekawa, R.2    Tanaka, H.3    Matsumoto, M.4    Takeda, Y.5    Tamura, Y.6    Nemori, R.7    Yoshioka, T.8
  • 26
    • 0031773610 scopus 로고    scopus 로고
    • Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques
    • Johnson JL, Jackson CL, Angelini GD, George SJ: Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 18:1707-1715, 1998
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1707-1715
    • Johnson, J.L.1    Jackson, C.L.2    Angelini, G.D.3    George, S.J.4
  • 27
    • 0035721934 scopus 로고    scopus 로고
    • Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein
    • Johnson JL, van Eys GJ, Angelini GD, George SJ: Injury induces dedifferentiation of smooth muscle cells and increased matrix-degrading metalloproteinase activity in human saphenous vein. Arterioscler Thromb Vasc Biol 21:1146-1151, 2001
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1146-1151
    • Johnson, J.L.1    Van Eys, G.J.2    Angelini, G.D.3    George, S.J.4
  • 29
    • 0036262509 scopus 로고    scopus 로고
    • Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography
    • Kurschat P, Wickenhauser C, Groth W, Krieg T, Mauch C: Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography. J Pathol 197:179-187, 2002
    • (2002) J Pathol , vol.197 , pp. 179-187
    • Kurschat, P.1    Wickenhauser, C.2    Groth, W.3    Krieg, T.4    Mauch, C.5
  • 32
    • 0034303643 scopus 로고    scopus 로고
    • Molecular profiling of human cancer
    • Liotta L, Petricoin E: Molecular profiling of human cancer. Nat Rev Genet 1:48-56, 2000
    • (2000) Nat Rev Genet , vol.1 , pp. 48-56
    • Liotta, L.1    Petricoin, E.2
  • 33
    • 0036302814 scopus 로고    scopus 로고
    • Protease degradomics: A new challenge for proteomics
    • Lopez-Otin C, Overall CM: Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol 3:509-519, 2002
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 509-519
    • Lopez-Otin, C.1    Overall, C.M.2
  • 36
    • 0033509855 scopus 로고    scopus 로고
    • Zymographic analysis of equine laminitis
    • Mungall BA, Pollitt CC: Zymographic analysis of equine laminitis. Histochem Cell Biol 112:467-472, 1999
    • (1999) Histochem Cell Biol , vol.112 , pp. 467-472
    • Mungall, B.A.1    Pollitt, C.C.2
  • 37
    • 0035952343 scopus 로고    scopus 로고
    • In situ zymography: Topographical considerations
    • Mungall BA, Pollitt CC: In situ zymography: topographical considerations. J Biochem Biophys Methods 47: 169-176, 2001
    • (2001) J Biochem Biophys Methods , vol.47 , pp. 169-176
    • Mungall, B.A.1    Pollitt, C.C.2
  • 38
    • 0031724139 scopus 로고    scopus 로고
    • Localisation of gelatinase activity in epidermal hoof lamellae by in situ zymography
    • Mungall BA, Pollitt CC, Collins R: Localisation of gelatinase activity in epidermal hoof lamellae by in situ zymography. Histochem Cell Biol 110:535-540, 1998
    • (1998) Histochem Cell Biol , vol.110 , pp. 535-540
    • Mungall, B.A.1    Pollitt, C.C.2    Collins, R.3
  • 39
    • 0036181880 scopus 로고    scopus 로고
    • Immunohistochemical study of membrane type-matrix metalloproteinases (MT-MMPs) and matrix metalloproteinase-2 (MMP-2) in dermatofibroma and malignant fibrous histiocytoma
    • Ohnishi Y, Ito Y, Tajima S, Ishibashi A, Arai K: Immunohistochemical study of membrane type-matrix metalloproteinases (MT-MMPs) and matrix metalloproteinase-2 (MMP-2) in dermatofibroma and malignant fibrous histiocytoma. J Dermatol Sci 28:119-125, 2002
    • (2002) J Dermatol Sci , vol.28 , pp. 119-125
    • Ohnishi, Y.1    Ito, Y.2    Tajima, S.3    Ishibashi, A.4    Arai, K.5
  • 40
    • 0035014695 scopus 로고    scopus 로고
    • Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors
    • Pagenstecher A, Wussler EM, Opdenakker G, Volk B, Campbell IL: Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors. J Neuropathol Exp Neurol 60:598-612, 2001
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 598-612
    • Pagenstecher, A.1    Wussler, E.M.2    Opdenakker, G.3    Volk, B.4    Campbell, I.L.5
  • 41
    • 0035722954 scopus 로고    scopus 로고
    • Matrix metalloproteinases in lung biology
    • Parks WC, Shapiro SD: Matrix metalloproteinases in lung biology. Respir Res 2:10-19, 2001
    • (2001) Respir Res , vol.2 , pp. 10-19
    • Parks, W.C.1    Shapiro, S.D.2
  • 43
    • 0034752257 scopus 로고    scopus 로고
    • Zymographic analysis of circulating and tissue forms of colon carcinoma gelatinase a (MMP-2) and B (MMP-9) separated by mono-and two-dimensional electrophoresis
    • Pucci-Minafra I, Minafra S, La Rocca G, Barranca M, Fontana S, Alaimo G, Okada Y: Zymographic analysis of circulating and tissue forms of colon carcinoma gelatinase A (MMP-2) and B (MMP-9) separated by mono-and two-dimensional electrophoresis. Matrix Biol 20: 419-427, 2001
    • (2001) Matrix Biol , vol.20 , pp. 419-427
    • Pucci-Minafra, I.1    Minafra, S.2    La Rocca, G.3    Barranca, M.4    Fontana, S.5    Alaimo, G.6    Okada, Y.7
  • 44
    • 0036187830 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression and activity following prostaglandin F(2 alpha)-induced luteolysis
    • Ricke WA, Smith GW, Smith MF: Matrix metalloproteinase expression and activity following prostaglandin F(2 alpha)-induced luteolysis. Biol Reprod 66:685-691, 2002
    • (2002) Biol Reprod , vol.66 , pp. 685-691
    • Ricke, W.A.1    Smith, G.W.2    Smith, M.F.3
  • 45
    • 0035110953 scopus 로고    scopus 로고
    • Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity
    • Stephens P, Davies KJ, Occleston N, Pleass RD, Kon C, Daniels J, Khaw PT, Thomas DW: Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. Br J Dermatol 144:229-237, 2001
    • (2001) Br J Dermatol , vol.144 , pp. 229-237
    • Stephens, P.1    Davies, K.J.2    Occleston, N.3    Pleass, R.D.4    Kon, C.5    Daniels, J.6    Khaw, P.T.7    Thomas, D.W.8
  • 46
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • Sternlicht MD, Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17:463-516, 2001
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 47
    • 0035000670 scopus 로고    scopus 로고
    • Proteases in invasion: Matrix metalloproteinases
    • Stetler-Stevenson WG, Yu AE: Proteases in invasion: matrix metalloproteinases. Semin Cancer Biol 11:143-152, 2001
    • (2001) Semin Cancer Biol , vol.11 , pp. 143-152
    • Stetler-Stevenson, W.G.1    Yu, A.E.2
  • 48
    • 0742278713 scopus 로고    scopus 로고
    • Localization of gelatinase activities in glioma tissues by film in situ zymography
    • Takano S, Tsuboi K, Matsumura A, Sato H, Nose T: Localization of gelatinase activities in glioma tissues by film in situ zymography. Brain Tumor Pathol 18:145-150, 2001
    • (2001) Brain Tumor Pathol , vol.18 , pp. 145-150
    • Takano, S.1    Tsuboi, K.2    Matsumura, A.3    Sato, H.4    Nose, T.5
  • 49
    • 0035184313 scopus 로고    scopus 로고
    • Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice
    • Teesalu T, Hinkkanen AE, Vaheri A: Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Am J Pathol 159:2227-2237, 2001
    • (2001) Am J Pathol , vol.159 , pp. 2227-2237
    • Teesalu, T.1    Hinkkanen, A.E.2    Vaheri, A.3
  • 51
    • 0036235417 scopus 로고    scopus 로고
    • Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging
    • Wang M, Lakatta EG: Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. Hypertension 39:865-873, 2002
    • (2002) Hypertension , vol.39 , pp. 865-873
    • Wang, M.1    Lakatta, E.G.2
  • 52
    • 0036090224 scopus 로고    scopus 로고
    • In vivo evidence for active matrix metalloproteinases in human endometrium supports their role in tissue breakdown at menstruation
    • Zhang J, Salamonsen LA: In vivo evidence for active matrix metalloproteinases in human endometrium supports their role in tissue breakdown at menstruation. J Clin Endocrinol Metab 87:2346-2351, 2002
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2346-2351
    • Zhang, J.1    Salamonsen, L.A.2
  • 53
    • 0036309731 scopus 로고    scopus 로고
    • A quantitative evaluation of active gelatinolytic sites in uterine endometrioid adenocarcinoma using film in situ zymography: Association of stronger gelatinolysis with myometrial invasion
    • Zheng K, Nagai Y, Kishimoto T, Yamazawa K, Tate S, Nemori R, Hirai Y, Sekiya S, Ishikura H: A quantitative evaluation of active gelatinolytic sites in uterine endometrioid adenocarcinoma using film in situ zymography: association of stronger gelatinolysis with myometrial invasion. Jpn J Cancer Res 93:516-522, 2002
    • (2002) Jpn J Cancer Res , vol.93 , pp. 516-522
    • Zheng, K.1    Nagai, Y.2    Kishimoto, T.3    Yamazawa, K.4    Tate, S.5    Nemori, R.6    Hirai, Y.7    Sekiya, S.8    Ishikura, H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.