Plasminogen activation in experimental permanent focal cerebral ischemia

Brain Research

Volumn 882, Issue 1-2, 2000, Pages 19-25

  Pfefferkorn, Thomas ^a   Wiessner, Christoph ^b   Allegrini, Peter R ^b   Staufer, Brigitte ^a   Vosko, Milan R ^a   Liebetrau, Martin ^a   Bueltemeier, Gundula ^a   Kloss, Christian U A ^a   Hamann, Gerhard F ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cerebral ischemia; In situ zymography; Plasminogen activation

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; PLASMINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN REGION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; RAT; ZYMOGRAPHY;

ANIMALS; BASAL GANGLIA; BRAIN ISCHEMIA; CEREBRAL CORTEX; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PLASMINOGEN; RATS; RATS, INBRED F344;

EID: 0034602091     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02769-4     Document Type: Article

References (27)

1. Application of magnetic resonance imaging to the measurement of neurodegeneration in the rat brain: MRI data correlate strongly with histology and enzymatic analysis
2. Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation
3. Matrix metalloproteinases (MMPs) and IL-8 CSF levels are correlated with brain edema following stroke
4. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
5. Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia
6. Ischaemic damage of brain microvessels: Inherent risk for thrombolytic treatment in stroke
7. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)
8. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion
9. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion
10. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia
11. Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice
12. Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia
13. Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system
14. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basal membrane
15. Cleavage of laminin by thrombin and plasmin: Alpha thrombin selectively cleaves the beta chain of laminin
16. Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats
17. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties
18. Plasminogen activation in focal cerebral ischemia and reperfusion
19. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat
20. Extracellular proteolysis in the adult murine brain
21. Characterization of the cerebroprotective effect of the competitive NMDA receptor antagonist CGP 40116 in a rat model of focal cerebral ischemia: An in vivo magnetic resonance study
22. Suppression of plasminogen activator inhibitor-1 release from human cerebral endothelium by plasminogen activators. A factor potentially predisposing to intracranial bleeding
23. Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
24. Tissue plasminogen activator for acute ischemic stroke
25. Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator
26. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice