Decreased expression of N-methyl-D-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freund's adjuvant-induced inflammation: An immunocytochemical study for NMDA NR1 subunit

Neuroscience Letters

Volumn 265, Issue 3, 1999, Pages 195-198

  Wang, Hang ^a   Zhang, Rui Xing ^a   Wang, Rui ^a   Qiao, Jian Tian ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Complete Freund's adjuvant; Dorsal root ganglion; Immunocytochemistry; N methyl D aspartate receptor; Nociception; Rats

Indexed keywords

FREUND ADJUVANT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT;

ANIMAL MODEL; ARTICLE; CELL COUNT; CONTROLLED STUDY; DESENSITIZATION; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MALE; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL PLASTICITY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR DOWN REGULATION; SPINAL GANGLION; TISSUE DISTRIBUTION;

ANIMALS; CELL SIZE; DOWN-REGULATION; FREUND'S ADJUVANT; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MALE; NEURITIS; NEURONS, AFFERENT; NOCICEPTORS; PAIN; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033597197     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00246-3     Document Type: Article

References (24)

1. Aanonsen L.M., Lei S., Wilcox G.L. Excitatory amino acid receptor and nociceptive neurotransmission in rat spinal cord. Pain. 41:1990;309-321.
2. Carlton S.M., Hargett G.L., Coggeshall R.E. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci. Lett. 197:1995;25-28.
3. Davies S.N., Lodge D. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res. 424:1987;402-406.
4. Dickenson A.H., Sullivan A.F. Evidence for a role of the NMDA receptor in the frequency dependent potentation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology. 26:1987;1235-1238.
5. Dubner R., Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15:1992;96-103.
6. Iadarola M.J., Douglass J., Civelli O., Narango J.R. Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization. Brain Res. 455:1988;205-212.
7. Iadarola M.J., Kim D.J., Caudle R.M. Analysis of c-terminal splice variants of the NMDA NR1 subunit in spinal cord using sequence specific antisera. Soc. Neurosci. Abstr. 22:1996;782.13.
8. Ju G., Höfelt T., Brodin E., Fabrenkrug J., Fischer J.A., Frey P., Elde R.P., Brown J.C. Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin- vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res. 247:1987;417-431.
9. Kolhekar R., Meller S.T., Gebhart G.F. Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat. Neuroscience. 57:1993;385-395.
10. 125I] MK-801 binding decrease in rat spinal cord after unilateral hind paw inflammation. Neuroscience. 68:1995;159-165.
11. Liu H., Wang H., Sheng M., Jan L.Y., Jan Y.N., Basbaum A.I. Evidence of presynaptic N-methyl-D-asparatate autoreceptors in the spinal dorsal horn. Proc. Natl. Acad. Sci. USA. 91:1994;8383-8387.
12. Lovinger D.M., Weight F.F. Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors. Neurosci. Lett. 94:1988;314-320.
13. Monaghan D.T., Bridges R.J., Cotman C.W. The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:1989;365-402.
14. Monyer H., Seeburg P.H., Wisden W. Glutamate-operated channels: developmentally early and mature form arise by alternative splicing. Neuron. 6:1991;799-810.
15. Mori H., Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology. 34:1995;1219-1237.
16. Moriyoski K., Masu M., Ishii T., Shigemeoto R., Mizuno N., Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature. 354:1991;31-37.
17. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
18. Ramgourg A., Clermont Y., Beaudet A. Ultrastructural features of six types of neurons in rat dorsal root ganglia. J. Neurocytol. 12:1983;47-66.
19. Ren K., Dubner R. NMDA receptor antagonist attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw. Neurosci. Lett. 163:1993;22-26.
20. Ren K., Hylden J.L., Williams G.M., Ruda M.A., Dubner R. The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain. 50:1992;331-344.
21. Ruda M.A., Iadarola M.J., Cohen L.V., Young W.S. III. In situ hybridization histochemistry and immunohistochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia. Proc. Natl. Acad. Sci. USA. 85:1988;622-626.
22. Sato K., Kiyama H., Park H.P., Tohyma M. AMPA, KA and NMDA receptors are expressed in the rat DRG neurons. NeuroReport. 4:1993;1263-1265.
23. Wang H., Liu R.J., Zhang R.X., Qiao J.T. Peripheral NMDA receptors contribute to activation of nociceptors: a c-fos expression study in rats. Neurosci. Lett. 201:1997;221-224.
24. Willis W.D. Jr., Coggeshall R.E. Sensory Mechanism of the Spinal Cord. 1991;Plenum, New York.