Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin

Journal of Virology

Volumn 77, Issue 15, 2003, Pages 8378-8385

  Matthews, Kate ^a   Leong, Cheng Mee ^a   Baxter, Lindsay ^a   Inglis, Emma ^a   Yun, Kankatsu ^a   Bäckström, B Thomas ^a   Doorbar, John ^b   Hibma, Merilyn ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN; VIRUS ANTIGEN; VIRUS PROTEIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL ADHESION; CELL COUNT; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; DEPLETION; DOWN REGULATION; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; IMMUNE RESPONSE; KERATINOCYTE; LANGERHANS CELL; MAJOR CLINICAL STUDY; NONHUMAN; ONCOVIRINAE; PERSISTENT INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; VIRAL SKIN DISEASE; VIRUS INFECTION; VIRUS SURVIVAL; WART VIRUS;

CADHERINS; CELL ADHESION; CELL LINE; CERVIX UTERI; DOWN-REGULATION; FEMALE; HUMANS; KERATINOCYTES; LANGERHANS CELLS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; REPRESSOR PROTEINS; SKIN; UTERINE CERVICAL DISEASES;

EID: 0038107894     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.15.8378-8385.2003     Document Type: Article

References (54)

1. Aiba, S., and S. I. Katz. 1990. Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J. Immunol. 145:2791-2796.
2. Angeli, V., C. Faveeuw, O. Roye, J. Fontaine, E. Teissier, A. Capron, I. Wolowczuk, M. Capron, and F. Trottein. 2001. Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J. Exp. Med. 193:1135-1147.
3. Becker, Y., and E. Sprecher. 1989. Langerhans cells in vaccinia virus infection in mouse skin. Arch. Virol. 107:307-313.
4. Bedell, M. A., J. B. Hudson, T. R. Golub, M. E. Turyk, M. Hosken, G. D. Wilbanks, and L. A. Laimins. 1991. Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation. J. Virol. 65:2254-2260.
5. Birchmeier, W., and J. Behrens. 1994. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1198:11-26.
6. Borkowski, T. A., B. J. Van Dyke, K. Schwarzenberger, V. W. McFarland, A. G. Farr, and M. C. Udey. 1994. Expression of E-cadherin by murine dendritic cells: E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells. Eur. J. Immunol. 24:2767-2774.
7. Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106:761-771.
8. Bukholm, I. K., J. M. Nesland, R. Karesen, U. Jacobsen, and A. L. Borresen-Dale. 1997. Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas. Virchows Arch. 431:317-321.
9. Charbonnier, A. S., N. Kohrgruber, E. Kriehuber, G. Stingl, A. Rot, and D. Maurer. 1999. Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal Langerhans cells. J. Exp. Med. 190:1755-1768.
10. Ciccolini, F., G. Di Pasquale, F. Carlotti, L. Crawford, and M. Tommasino. 1994. Functional studies of E7 proteins from different HPV types. Oncogene 9:2633-2638.
11. Cumberbatch, M., R. J. Dearman, and I. Kimber. 1996. Adhesion molecule expression by epidermal Langerhans cells and lymph node dendritic cells: a comparison. Arch. Dermatol. Res. 288:739-744.
12. Cumberbatch, M., R. J. Dearman, and I. Kimber. 1997. Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration. Immunology 92:388-395.
13. Dittmar, M. T., G. Simmons, S. Hibbitts, M. O'Hare, S. Louisirirotchanakul, S. Beddows, J. Weber, P. R. Clapham, and R. A. Weiss. 1997. Langerhans cell tropism of human immunodeficiency virus type 1 subtype A through F isolates derived from different transmission groups. J. Virol. 71: 8008-8013.
14. Doorbar, J., C. Foo, N. Coleman, L. Medcalf, O. Hartley, T. Prospero, S. Napthine, J. Sterling, G. Winter, and H. Griffin. 1997. Characterization of events during the late stages of HPV16 infection in vivo using high-affinity synthetic Fabs to E4. Virology 238:40-52.
15. Durst, M., L. Gissmann, H. Ikenberg, and H. zur Hausen. 1983. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80: 3812-3815.
16. El-Sherif, A. M., R. Seth, P. J. Tighe, and D. Jenkins. 2000. Decreased synthesis and expression of TGF-β1, β2, and β3 in epithelium of HPV 16-positive cervical precancer: a study by microdissection, quantitative RTPCR, and immunocytochemistry. J. Pathol. 192:494-501.
17. Ghaznawie, M., J. M. Papadimitriou, and P. J. Heenan. 1999. The staedy-state turnover of murine epidermal Langerhans cells. Br. J. Dermatol. 141: 57-61.
18. Gupta, D., J. Holden, and L. Layfield. 2001. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Appl. Immunohistochem. Mol. Morphol. 9:86-91.
19. Hernando, R. A., J. C. Ruby, and G. M. Halliday. 1994. Changes in epidermal Langerhans cells, gamma delta T cells and CD4 T cells after intradermal infection with recombinant vaccinia virus expressing cytokine genes. Immunol. Cell Biol. 72:383-389.
20. Hibma, M. H., K. Raj, S. J. Ely, M. Stanley, and L. Crawford. 1995. The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2. Eur. J. Biochem. 229:517-525.
21. Jakob, T., M. J. Brown, and M. C. Udey. 1999. Characterization of E-cadherin-containing junctions involving skin-derived dendritic cells. J. Investig. Dermatol. 112:102-108.
22. Jakob, T., and M. C. Udey. 1998. Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J. Immunol. 160:4067-4073.
23. Johnston, L. J., G. M. Halliday, and N. J. King. 2000. Langerhans cells migrate to local lymph nodes following cutaneous infection with an arbovirus. J. Investig. Dermatol. 114:560-568.
24. Keen, N., R. Elston, and L. Crawford. 1994. Interaction of the E6 protein of human papillomavirus with cellular proteins. Oncogene 9:1493-1499.
25. + cells differentiate into Langerhans cells. Nat. Immunol. 2:1151-1158.
26. Larsen, C. P., S. C. Ritchie, T. C. Pearson, P. S. Linsley, and R. P. Lowry. 1992. Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. J. Exp. Med. 176:1215-1220.
27. Magal, S. S., A. Jackman, X. F. Pei, R. Schlegel, and L. Sherman. 1998. Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins. Int. J. Cancer 75:96-104.
28. Mahajan, N. P., K. Linder, G. Berry, G. W. Gordon, R. Heim, and B. Herman. 1998. Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer. Nat. Biotechnol. 16:547-552.
29. Miyagi, J., T. Kinjo, K. Tsuhako, M. Higa, T. Iwamasa, Y. Kamada, and T. Hirayasu. 2001. Extremely high Langerhans cell infiltration contributes to the favorable prognosis of HPV-infected squamous cell carcinoma and adenocarcinoma of the lung. Histopathology 38:355-367.
30. Morelli, A. E., C. Sananes, G. Di Paola, A. Paredes, and L. Fainboim. 1993. Relationship between types of human papillomavirus and Langerhans' cells in cervical condyloma and intraepithelial neoplasia. Am. J. Clin. Pathol. 99: 200-206.
31. Morris, H. H., K. C. Gatter, G. Sykes, V. Casemore, and D. Y. Mason. 1983. Langerhans' cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia. Br. J. Obstet. Gynaecol. 90:412-420.
32. Mueller, S., E. Cadenas, and A. H. Schonthal. 2000. p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression. Cancer Res. 60:156-163.
33. Park, T. W., H. Fujiwara, and T. C. Wright. 1995. Molecular biology of cervical cancer and its precursors. Cancer 76:1902-1913.
34. Romani,N., S. Koide, M. Crowley, M. Witmer-Pack, A. M. Livingstone, C. G. Fathman, K. Inaba, and R. M. Steinman. 1989. Presentation of exogenous protein antigens by dendritic cells to T-cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169:1169-1178.
35. Schwarzenberger, K., and M. C. Udey. 1996. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J. Investig. Dermatol. 106:553-558.
36. Sprecher, E., and Y. Becker. 1987. Herpes simplex virus type 1 pathogenicity in footpad and ear skin of mice depends on Langerhans cell density, mouse genetics, and virus strain. J. Virol. 61:2515-2522.
37. Sprecher, E., and Y. Becker. 1989. Langerhans cell density and activity in mouse skin and lymph nodes affect herpes simplex type 1 (HSV-1) pathogenicity. Arch. Virol. 107:191-205.
38. Stanley, M. A., H. M. Browne, M. Appleby, and A. C. Minson. 1989. Properties of a non-tumorigenic human cervical keratinocyte cell line. Int. J. Cancer 43:672-676.
39. Stingl, G., S. I. Katz, L. Clement, I. Green, and E. M. Shevach. 1978. Immunologic functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121:2005-2013.
40. Tang, A., M. Amagai, L. G. Granger, J. R. Stanley, and M. C. Udey. 1993. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361:82-85.
41. Tay, S. K., D. Jenkins, P. Maddox, M. Campion, and A. Singer. 1987. Subpopulations of Langerhans' cells in cervical neoplasia. Br. J. Obstet. Gynaecol. 94:10-15.
42. Thomas, R. M., D. V. Belsito, C. Huang, L. Z. Chen Lz, I. Ormsby, W. J. Simmons, P. Cowin, J. Shaw, T. Doetschman, and G. J. Thorbecke. 2001. Appearance of Langerhans cells in the epidermis of Tgfb1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-β1 and -β2(1). J. Investig. Dermatol. 117:1574-1580.
43. Tindle, R. W. 2002. Immune evasion in human papillomavirus-associated cervical cancer. Nat. Rev. Cancer 2:59-65.
44. Tsukahara, T., and Y. Horiuchi. 1996. Immunohistochemical study of cellular events in lesional skin during common virus infections. J. Dermatol. 23: 22-32.
45. Vermeulen, S., V. Van Marck, L. Van Hoorde, F. Van Roy, M. Bracke, and M. Mareel. 1996. Regulation of the invasion suppressor function of the cadherin/catenin complex. Pathol. Res. Pract. 192:694-707.
46. Vessey, C. J., J. Wilding, N. Folarin, S. Hirano, M. Takeichi, P. Soutter, G. W. Stamp, and M. Pignatelli. 1995. Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. J. Pathol. 176:151-159.
47. Vousden, K. H. 1994. Interactions between papillomavirus proteins and tumor suppressor gene products. Adv. Cancer Res. 64:1-24.
48. Walboomers, J. M., M. V. Jacobs, M. M. Manos, F. X. Bosch, J. A. Kummer, K. V. Shah, P. J. Snijders, J. Peto, C. J. Meijer, and N. Munoz. 1999. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 189:12-19.
49. Wang, B., S. Kondo, G. M. Shivji, H. Fujisawa, T. W. Mak, and D. N. Sauder. 1996. Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells. Immunology 88:284-288.
50. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
51. Wyllie, F. S., M. F. Haughton, J. M. Rowson, and D. Wynford-Thomas. 1999. Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53. Br. J. Cancer 79:1111-1120.
52. Yoo, J., S. Park, C. S. Kang, S. J. Kang, and B. K. Kim. 2002. Expression of E-cadherin and p53 proteins in human soft tissue sarcomas. Arch. Pathol. Lab. Med. 126:33-38.
53. Zimmer, M. I., A. T. Larregina, C. M. Castillo, S. Capuano III, L. D. Falo, Jr., M. Murphey-Corb, T. A. Reinhart, and S. M. Barratt-Boyes. 2002. Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood 99:2859-2868.
54. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.