Characterization of events during the late stages of HPV16 infection in vivo using high-affinity synthetic Fabs to E4

Virology

Volumn 238, Issue 1, 1997, Pages 40-52

  Doorbar, John ^a,b   Foo, Charmaine ^c   Coleman, Nick ^c   Medcalf, Liz ^c   Hartley, Oliver ^d   Prospero, Terence ^d   Napthine, Sawsan ^c   Sterling, Jane ^c   Winter, Greg ^d   Griffin, Heather ^d  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

Antibodies; Epithelial differentiation; HPV E4; Late gene expression; Phage display; Vegetative viral DNA replication

Indexed keywords

MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; GENE EXPRESSION REGULATION; PHAGE DISPLAY; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS REPLICATION; WART VIRUS;

DNA VIRUSES; HUMAN PAPILLOMAVIRUS TYPES;

EID: 0031564066     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8768     Document Type: Article

References (50)

1. Beyer-Finkler, E., Stoler, M. H., Giradi, F., and Pfister, H. (1990). Cell-differentiation-related gene expression of human papillomavirus 33. Med. Microbiol. Immunol. 179, 185-192.
2. Breitburd, F., Croissant, O., and Orth, G. (1987). Expression of human papillomavirus type-1 E4 gene products in warts. In "Cancer Cells 5" (B. M. Steinberg, J. L. Brandsma, and L. B. Taichman, Eds.), pp. 115-122. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. Brown, D. R., Fan, L., Jones, J., and Bryan, J. (1994). Colocalization of human papillomavirus type 11 E1 ∧ E4 and L1 proteins in human foreskin implants grown in athymic mice. Virology 201, 46-54.
4. Chow, L. T., and Broker, T. R. (1994). Papillomavirus DNA replication. Intervirology 37, 150-158.
5. Croissant, O., Breitburd, F., and Orth, G. (1985). Specificity of the cytopathic effect of cutaneous human papillomaviruses. Clin. Dermatol. 3(4), 43-55.
6. Crum, C. P., Barber, S., Symbula, M., Snyder, K., Saleh, A. M., and Roche, J. K. (1990). Coexpression of the human papillomavirus type 16 E4 and L1 open reading frames in early cervical neoplasia. Virology 178, 238-246.
7. de Villers, E. M. (1994). Human pathogenic papillomavirus types: An update. In "Human Pathogenic Papillomaviruses" (H. Zur Hausen, Ed.), pp. 1-12. Springer-Verlag, Heidelberg.
8. Doorbar, J. (1996). The E4 proteins and their role in the viral life cycle. In "Papillomavirus Reviews: Current Research on Papillomaviruses" (C. Lacey, Ed.), pp. 31-38. Leeds Medical Information, Leeds Univ. Press, Leeds.
9. Doorbar, J., Campbell, D., Grand, R. J. A., and Gallimore, P. H. (1986). Identification of the human papillomavirus-1a E4 gene products. EMBO J. 5(2), 355-362.
10. Doorbar, J., Coneron, I., and Gallimore, P. H. (1989). Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses. Virology 172, 51-62.
11. Doorbar, J., Ely, S., Coleman, N., Hibma, M., Davies, D. H., and Crawford, L. (1992). Epitope mapped monoclonal antibodies against the HPV16 E1 ∧ E4 protein. Virology 187, 353-359.
12. Doorbar, J., Ely, S., Sterling, J., McLean, C., and Crawford, L. (1991). Specific interaction between HPV16 E1 ∧ E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network. Nature 352, 824-827.
13. Doorbar, J., Evans, H. S., Coneron, I., Crawford, L. V., and Gallimore, P. H. (1988). Analysis of HPV1 E4 gene expression using epitope-defined antibodies. EMBO J. 7(3), 825-833.
14. Doorbar, J., and Gallimore, P. H. (1987). Identification of proteins encoded by the L1 and L2 open reading frames of human papillomavirus type 1a. J. Virol. 61, 2793-2799.
15. Doorbar, J., Medcalf, M., and Napthine, S. (1996). Analysis of HPV1 E4 complexes and their association with keratins in vivo. Virology 218, 114-126.
16. Doorbar, J., and Myers, G. (1996). The E4 protein. In "Human Papillomaviruses 1996" (G. Myers, H. Delius, J. lcenogel, H.-U. Bernard, C. Baker, A. Halpern, and C. Wheeler, Eds.), Vol. III, pp. 58-80. Los Alamos National Laboratory, Los Alamos, NM.
17. Egawa, K. (1994). New types of human papillomaviruses and intracytoplasmic inclusion bodies: A classification of inclusion warts according to clinical features, histology and associated HPV types. Br. J. Dermatol. 130, 158-166.
18. Egawa, K., Delius, H., Matsukura, T., Kawashima, M., and Villiers de, E.-M. (1993a). Two novel types of human papillomavirus, HPV63 and HPV65: Comparison of their clinical and histological features and DNA sequences to other HPV types. Virology 194, 51-62.
19. Egawa, K., Inaba, Y., Yoshimura, K., and Ono, T. (1993b). Varied clinical morphology of HPV-1-induced warts, depending on anatomical factors. Br. J. Dermatol. 128, 271-276.
20. Frattini, M. G., Lim, H. B., and Laimins, L. A. (1996). In-vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late gene expression. Proc. Natl. Acad. Sci. USA 93(7), 3062-3067.
21. Grand, R. J. A., Doorbar, J., Smith, K. J., Coneron, I., and Gallimore, P. H. (1989). Phosphorylation of the human papillomavirus type 1 E4 proteins in vivo and in vitro. Virology 170, 201-213.
22. Green, N., Alexander, H., Olson, A., Alexander, S., Shinnick, T. M., Sutcliffe, J. G., and Lerner, R. A. (1982). Immunogenic structure of the influenza virus hemagglutinin. Cell 28, 477-487.
23. Griffiths, A. D., Williams, S. C., Hartley, O., Tomlinson, I., Waterhouse, P., Crosby, W. L., Kontermann, R. E., Jones, P. T., Low, N. M., Allison, T. J., Prospero, T. D., Hoogenboom, H. R., Nissim, A., Cox, J. P. L., Harrison, J. L., Zaccolo, M., Gherardi, E., and Winter, G. (1994). Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245-3260.
24. Hawkins, R. E., Russell, S. J., and Winter, G. (1992). Selection of phage antibodies by binding affinity. J. Mol. Biol. 226, 889-896.
25. Hudson, D. L., Weiland, K. L., Dooley, T. P., Simon, M., and Watt, F. M. (1992). Characterization of eight monoclonal antibodies to involucrin. Hybridoma 11(3), 367-378.
26. Jareborg, N., and Burnett, S. (1991). Immunofluorescent detection of bovine papillomavirus E4 antigen in the cytoplasm of cells permissive in vitro for viral DNA amplification. J. Gen. Virol. 72, 2269-2274.
27. Johnson, B., Lofas, S., and Lindquist, G. (1991). Imobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198, 268-277.
28. Laimins, L. A. (1993). The biology of human papillomaviruses: From warts to cancer. Infectious Agents Dis. 2, 74-86.
29. Lambert, P. F. (1991). Papillomavirus DNA replication. J. Virol. 65, 3417-3420.
30. Low, N. M., Holliger, P., and Winter, G. (1996). Mimicking somatic hypermutation - Affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. J. Mol. Biol. 260(3), 359-368.
31. Marks, J. D., Griffiths, A. D., Malmqvist, M., Clackson, T., Bye, J. M., and Winter, G. (1992). Bypassing immunization - Building high affinity human antibodies by chain shuffling. Biotechnology 10(7), 779-783.
32. McClean, C. S., Churcher, M. J., Meinke, J., Smith, G. L., Higgins, G., Stanley, M. A., and Minson, M. C. (1990). Production and characterisation of a monoclonal antibody to human papillomavirus type 16 using a recombinant vaccinia virus. J. Clin. Pathol. 43, 488-492.
33. Meyers, C., Frattini, M. G., Hudson, J. B., and Laimonis, L. A. (1992). Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation. Science 257, 971-973.
34. Nissim, A., Hoogenboom, H. R., Tomlinson, I. M., Flynn, G., Midgley, C., Lane, D., and Winter, G. (1994). Antibody fragments from a 'single pot' phage display library as immunochemical reagents. EMBO J. 13, 692-698.
35. Palefsky, J. M., Winkler, B., Rabanus, J.-P., Clark, C., Chan, S., Nizet, V., and Schoolnik, G. K. (1991). Characterisation of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues. J. Clin. Invest. 87, 2132-2141.
36. Pope, A., Pritchard, K., Williams, A., Roberts, A., Hackett, J. R., Mandecki, W., and Johnson, K. S. (1996). In-vitro selection of a high-affinity antibody to estradiol using a phage display human-antibody library. Immunotechnology 2(3), 209-217.
37. Pray, T. R., and Laimins, L. A. (1995). Differentiation-dependent expression of E1 ∧ E4 proteins in cell lines maintaining episomes of human papillomavirus type 31b. Virology 206, 679-685.
38. Roberts, J. M., and Weintraub, H. (1986). Negative control of DNA replication in composite SV40-bovine papillomavirus plasmids. Cell 46, 741 -752.
39. Roberts, S., Ashmole, I., Gibson, L., Rookes, S. M., Barton, G. J., and Gallimore, P. H. (1994). Mutational analysis of human papillomavirus E4 proteins: Identification of structural features important in the formation of cytoplasmic E4/cytokeratin networks in epithelial cells. J. Virol. 68(10), 6432-6455.
40. Roberts, S., Ashmole, I., Johnson, G. D., Kreider, J. W., and Gallimore, P. H. (1993). Cutaneous and mucosal human papillomavirus E4 proteins form intermediate filament-like structures in epithelial cells. Virology 197, 176-187.
41. Rogel-Gaillard, C., Breitburd, F., and Orth, G. (1992). Human papillomavirus type 1 E4 proteins differing by their N-terminal ends have distinct cellular locations when transiently expressed in vitro. J. Virol. 66(2), 816-823.
42. Rogel-Gaillard, C., Pehau-Arnaudet, G., Breitburd, F., and Orth, G. (1993). Cytopathic effect in human papillomavirus type 1-induced inclusion warts: In vitro analysis of the contribution of two forms of the viral E4 protein. J. Invest. Dermatol. 101, 843-851.
43. Schier, R., McCall, A., Adams, G. P., Marshall, K. W., Merritt, H., and Yim, M. (1996). Isolation of picomolar affinity anti-c-erbb-2 single chain FV by molecular evolution of the complimentary-determining regions in the centre of the antibody-binding site. J. Mol. Biol. 263(4), 551-567.
44. Schneider, A. (1994). Natural history of genital papillomavirus infections. Intervirology 37(3-4), 201-214.
45. Sherman, L., and Schlegel, R. (1996). Serum-induced and calcium-induced differentiation of human keratinocytes is inhibited by the E6 protein of human papillomaviruses. J. Virol. 70, 3269-3279.
46. Stoler, M. H., Whitbeck, S. M., Wolinsky, S. M., Broker, T. R., Chow, L. T., Howett, M. K., and Kreider, J. W. (1990). Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice. J. Virol. 64, 3310-3318.
47. Stoppler, M. C., Ching, K., Stoppler, H., Clancey, K., Schlegel, R., and Icenogle, J. (1996). Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J. Virol. 70, 6987-6993.
48. Wiley, S. R., Kraus, R. J., Zuo, R. G., Murray, E. E., Loritz, K., and Mertz, J. E. (1993). SV40 early to late switch involves titration of cellular transcription repressers. Genes Dev. 7, 2206-2219.
49. Wright, T. C., Kurman, R. J., and Ferenczy, A. (1994). Precancerous lesions of the cervix. In "Blaustein's Pathology of the Female Genital Tract" (R. J. Kurman, Ed.), pp. 229-277. Springer-Verlag, New York.
50. Zheng, Z.-M., He, P., and Baker, C. C. (1996). Selection of the bovine papillomavirus type 1 nucleotide 3225 3′ splice site is regulated through an exonic splicing enhancer. J. Virol. 70, 4691-4699.