The spatial distribution of human immunoglobulin genes within the nucleus: Evidence for gene topography independent of cell type and transcriptional activity

Human Genetics

Volumn 100, Issue 5-6, 1997, Pages 588-594

  Parreira, Leonor ^a   Telhada, Margarida ^a   Ramos, Carlos ^a   Hernandez, Rosa ^a   Neves, Hélia ^a   Carmo Fonseca, Maria ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ARTICLE; B LYMPHOCYTE; CELL NUCLEUS; CELL TYPE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCATION; GENE STRUCTURE; GENETIC ORGANIZATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IN SITU HYBRIDIZATION; LYMPHOID CELL; PRIORITY JOURNAL; TOPOGRAPHY;

B-LYMPHOCYTES; CELL NUCLEUS; CENTROMERE; CHROMOSOMES, HUMAN, PAIR 2; DNA; GENES; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROSCOPY, CONFOCAL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCR; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031431812     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050558     Document Type: Article

References (36)

1. Bartholdi MF (1991) Nuclear distribution of centromeres during the cell cycle of human diploid fibroblasts. J Cell Sci 99:255-263
2. Carter KC, Lawrence JB (1991) DNA and RNA within the nucleus: how much sequence-specific spatial organization. J Cell Biochem 47:124-129
3. Carvalho C, Telhada M, Carmo-Fonseca M, Parreira L (1995) In situ visualization of immunoglobulin genes in normal and malignant lymphoid cells. J Clin Pathol: Mol Pathol 48:M158-M164
4. Chen J, Alt FW (1993) Gene rearrangement and B-cell development. Curr Opin Immunol 5:194-200
5. Conover WJ (1980) In: Practical non-parametric statistics. John Wiley and Sons, New York
6. Cremer T, Kurz A, Zirbel R, Dietzel S, Rinke B, Schrock E, Speicher MR, Mathieu U, Jauch A, Emmerich P, Scherthan H, Ried T, Cremer C, Lichter P (1993) Role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp Quant Biol 58:777-792
7. Croce CM, Huebner K, Isobe M, Fainstein E, Lifshitz B, Shtivelman E, Canaani E (1987) Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogeneous leukemia breakpoints. Proc Natl Acad Sci USA 84:7174-7178
8. Diamond J, Goldman JM, Melo JV (1995) BCR-ABL, ABL-BCR, BCR and ABL genes are all expressed in individual granulocyte-macrophage colony-forming unit (CFU-GM) colonies from blood of patients with chronic myeloid leukemia. Blood 85:2171-2175
9. Dietzel S, Weiland E, Eils R, Christian M, Cremer C, Cremer T (1995) Three-dimensional distribution of centromeric or paracentromeric heterochromatin of chromosomes 1, 7, 15 and 17 in human lymphocyte nuclei studied with light microscopic axial tomography. Bioimaging 3:121-133
10. Ferguson M, Ward DC (1992) Cell cycle dependent chromosomal movement in premitotic human T-lymphocyte nuclei. Chromosoma 101:557-565
11. Haaf T, Schmid M (1989) Centromeric association and non-random distribution of centromeres in human tumour cells. Hum Genet 81:137-143
12. Haaf T, Schmid M (1991) Chromosome topology in mammalian interphase nuclei. Exp Cell Res 192:325-332
13. Hagman J, Grosschedl R (1994) Regulation of gene expression at early stages of B-cell differentiation. Curr Opin Immunol 16: 222-230
14. Hilliker AJ, Appels R (1989) The arrangement of interphase chromosomes: structural and functional aspects. Exp Cell Res 185: 297-318
15. Hulspas R, Houtsmuller A, Krijtenburg P-J, Bauman JGJ, Nanninga N (1994) The nuclear position of pericentromeric DNA of chromosome 11 appears to be random in GO and non-random in G1 human lymphocytes. Chromosoma 103:286-292
16. Jackson DA (1991) Structure-function relationships in eukaryotic nuclei. Bioessays 13:1-10
17. Klaus GG (1987) In: Lymphocytes. A practical approach. IRL Press, Oxford, pp 26-28
18. Lawrence JB, Villnave CA, Singer RH (1988) Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma cell line. Cell 52:51-61
19. Lawrence JB, Carter KC, Xing Y (1993) Probing functional organization within the nucleus: is genome structure integrated with RNA metabolism? Cold Spring Harbor Symp Quant Biol 58: 807-818
20. Manuelidis L (1984) Different central nervous system cell types display distinct and non random arrangements of satellite DNA sequences. Proc Natl Acad Sci USA 81:3123-3127
21. Manuelidis L (1985) Individual interphase chromosome domains revealed by in situ hybridization. Hum Genet 71:288-293
22. Manuelidis L (1990) A view of interphase chromosomes. Science 250:1533-1539
23. Manuelidis L, Borden J (1988) Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction. Chromosoma 96:397-410
24. Marshall WF, Dernburg AF, Harmon B, Agard DA, Sedat JW (1996) Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell 7:825-842
25. Melo JV, Brito-Babapulle V, Foroni L, Robinson DSF, Luzzatto L, Catovsky D (1986) Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement. Int J Cancer 38:531-538
26. Münkel C, Eils R, Imhoff J, Dietzel S, Cremer C, Cremer T (1995) Simulation of the distribution of chromosome targets in cell nuclei under topological constraints. Bioimaging 3:108-120
27. Nelson B, Sen R (1992) Regulation of immunoglobulin gene transcription. Int Rev Cytol 133:121-149
28. Pombo A, Ferreira J, Bridge E, Carmo-Fonseca M (1994) Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells. EMBO J 13:5075-5085
29. Rabbitts TH, Forster A, Milstein CP (1981) Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences. Nucleic Acids Res 9:4509-4524
30. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
31. Scheer U, Thiry M, Goessens G (1993) Structure, function and assembly of the nucleolus. Trends Cell Biol 3:237-241
32. Staudt LM, Lenardo MJ (1991) Immunoglobulin gene transcription. Annu Rev Immunol 9:373-398
33. Telhada M, Carvalho C, Carmo-Fonseca M, Parreira L (1995) Influence of transcription and replication on the in situ resolution of immunoglobulin heavy-chain constant region genes: an interphase cytogenetics analysis. Hum Genet 96:552-561
34. Weimer R, Haaf T, Kruger J, Foot M, Schmid M (1992) Characterization of centromere arrangements and test for random distribution in G0, G1, S, G2, G1' and early S' phase in human lymphocytes. Hum Genet 88:673-682
35. Xing Y, Johnson CV, Dobner PR, Lawrence JB (1993) Higher level organization of individual gene transcription and RNA splicing. Science 259:1326-1330
36. Zirbel RM, Mathieu UR, Kurz A, Cremer T, Lichter P (1993) Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chromosome Res 1:93-106