Telomerase activity and telomere length in malignant cells of children with acute lymphoblastic leukemia

Experimental Oncology

Volumn 25, Issue 1, 2003, Pages 69-73

  Kustanovich, A M ^a   Savitskaya, T V ^a   Potapnev, M P ^a  

^a Belarusian Research Center for Pediatric Oncology and Hematology   (Belarus)

Author keywords

Acute lymphoblastic leukemia; Children; HTERT; Telomerase; Telomeres

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; MESSENGER RNA; RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW CELL; CATALYSIS; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; REMISSION; SOMATIC CELL; TELOMERE; BONE MARROW; CANCER CELL; CANCER REGRESSION; CATALYST; CLINICAL ARTICLE; LEUKOCYTE; PROTEIN EXPRESSION;

EID: 0038032928     PISSN: 02043564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Egorov EE. Around the telomerase. Mol Biol 1999; 33: 385-92 (in Russian).
2. Aisner DL, Wright WE, Shay JW. Telomerase regulation: not just flipping the switch. Curr Opinion Gen Dev 2002; 12: 80-5.
3. Aldous W, Marean A, DeHart J, Matej L, Moore K. Effects of tamoxifen on telomerase activity in breast carcinoma cell lines. Cancer 1999; 85: 1523-9.
4. Avilion AA, Piatyszek MA, Gupta J, Shay JW, Bacchetti S, Greider CW. Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 1996; 56: 645-50.
5. Belair CD, Yeager TR, Patricia M, Lopez PM, Reznikoff CA. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci USA 1997; 94: 13677-82.
6. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
7. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987; 162: 156-62.
8. Collins K, Mitchell JR. Telomerase in the human organism. Oncogene 2002; 21: 564-79.
9. Counter CM, Meyerson M, Eaton EN, Ellisen LW, Caddle SD, Haber DA, Weinberg RA. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998; 16: 1217-22.
10. Engelhardt M, Ozkaynak MF, Drullinsky P, Sandoval C, Tugal O, Jayabose S, Moore MA. Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy. Leukemia 1998; 12: 13-24.
11. Hamad NM, Banik SS, Counter CM. Mutational analysis defines a minimum level of telomerase activity required for tnmourigenic growth of human cells. Oncogene 2002; 21: 7121-5.
12. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
13. Harley CB, Morin GB. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997; 17: 498-502.
14. Hodes RJ, Hathcock KS, Weng NP. Telomeres in T and B cells. Nat Rev Immunol 2002; 2: 699-706.
15. Hu BT, Insel RA. Up-regulation of telomerase in human B-lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit. Eur J Immunol 1999; 29: 3745-53.
16. Igarashi H, Sakaguchi N. Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes. Biochem Biophys Res Commun 1996; 219: 649-55.
17. Jiang X-R, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tisty TD, Chiu CP. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999; 21: 111-4.
18. Kim N, Wu F. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res 1997; 25: 2595-7.
19. Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392: 569-74.
20. Meyerson M. Role of telomerase in normal and cancer cells. J Cell Oncol 2000; 18: 2626-34.
21. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997; 90: 785-95.
22. Norrback KF, Dahlenborg K, Carlsson R, Roos G. Telomerase activation in normal B lymphocytes and nonHodgkin's lymphomas. Blood 1996; 88: 222-9.
23. Ohki R, Tsurimoto T, Ishikawa F. In vitro reconstitution of the end replication problem. Mol Cell Biol 2001; 21: 5753-66.
24. Ohyashiki JH, Sashida G, Tauchi T, Ohyashiki K. Telomeres and telomerase in hematologic neoplasia. Oncogene 2002; 21: 680-7.
25. Raff T, van der Gief, Endemann D, Wiederholt T, Paul M. Design and testing of β-actin primers that do not coamplify processed pseudogenes. BioTechniques 1997; 23: 456-60.
26. Reddel RR, Bryan TM, Murnane JP. Immortalized cells with no detectable telomerase activity. Biochemistry (Mosc) 1997; 62: 1254-62.
27. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 1998; 58: 4168-72.
28. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998; 8: 279-82.
29. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Weng NP, Palmer LD, Levine BL, Lane HC, June CH, Hodes RJ. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev 1997; 160: 43-54.
30. Yi X, Shay JW, Wright WE. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res 2001; 29: 4818-25.
31. Yamada K, Yajima T, Yagihashi A, Kobayashi D, Koyanagi Y, Asanuma K, Yamada M, Moriai R, Kameshima H, Watanabe N. Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic cells. Jpn J Cancer Res 2000; 91: 1278-84.
32. Yokoyama Y, Wan X, Takahashi Y, Shinohara A, Tamaya T. Alternatively spliced variant deleting exons 7 and 8 of the hTERT is dominantly expressed in uterus. Mol Human Reproduction 2001; 7: 853-7.