Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells

Immunology

Volumn 101, Issue 3, 2000, Pages 316-324

  Gong, J ^a,e   Apostolopoulos, V ^b,c   Chen, D ^a   Chen, H ^a   Koido, S ^a   Gendler, S J ^d   Mckenzie, I F ^b   Kufe, D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b AUSTIN RESEARCH INSTITUTE   (Australia)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d MAYO CLINIC   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL FUSION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GENETIC SELECTION; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL FUSION; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; IMMUNIZATION; LUNG NEOPLASMS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TUMOR CELLS, CULTURED;

EID: 0033661660     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00101.x     Document Type: Article

References (50)

1. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
2. Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors
3. Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoprotein expressed by human mammary epithelium
4. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen
5. The human tumor associated epithelial mucins are coded by an expressed hypervariable gene locus PUM
6. Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas
7. Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line
8. Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen
9. Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin
10. Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development
11. Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity
12. Suppression of cellular aggregation by high levels of episialin
13. Episialin (MUC1) overexpression inhibitions integrin-mediated cell adhesion to extracellular matrix components
14. A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1
15. Humoral immunity against a tandem repeat epitope of human mucin MUC1 in sera from breast, pancreatic and colon cancer patients
16. Human B-cell immune response to the polymorphic epithelial mucin
17. Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein
18. Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells
19. Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells
20. Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides
21. In vitro induction of MUC-1 peptide specific type-1 lymphocyte and CTL responses from healthy multiparous donors
22. CTL in mice immunized with human mucin 1 are MHC-restricted
23. Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell costimulatory molecule B7
24. Vaccinia virus MUC1 immunization of mice: Immune response and protection against the growth of murine tumors bearing the MUC1 antigen
25. Vaccination against tumor cells expressing breast cancer epithelial tumor antigen
26. Induction of antigen-specific antitumor immunity with adenoviral-transduced dendritic cells
27. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
28. Cyclophosphamide enhances the CTL precursor frequency in mice immunized with MUC1-mannan fusion protein (M-FP)
29. Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model
30. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells
31. Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice
32. Circulating DF3 and CA125 antigen levels in serum from patients with epithelial ovarian cancer
33. MUC1 peptide epitopes associated with five different H-2 class I molecules
34. Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules
35. A fail-safe mechanism for maintaining self-tolerance
36. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
37. Help for cytotoxic-T-cell responses is mediated by CD40 signaling
38. A conditional dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
39. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
40. Ligation of CD40 on dendritic cells triggers production of high level of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
41. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
42. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice
43. CD40 ligand-transduced costimulation of T cells in the development of helper function
44. Conversion of tumor-specific CD4+ T cell tolerance to T cell priming through in vivo ligation of CD40
45. Generation, translocation, and presentation of MHC class I-restricted peptides
46. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
47. A mechanism for the specific immunogenicity of heat shock-chaperoned peptides
48. Capture and processing of exogenous antigens for presentation on MHC molecules
49. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
50. + T cell help