Transcriptional profiling during the early differentiation of granulocyte and monocyte progenitors controlled by conditional versions of the E2a-Pbx1 oncoprotein

Leukemia and Lymphoma

Volumn 44, Issue 7, 2003, Pages 1187-1199

  Sykes, David B ^a   Scheele, Jurgen ^a   Pasillas, Martina ^a   Kamps, Mark P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

E2a Pbx1 oncoprotein; Early differentiation of precursors; Granulocyte and monocyte progenitors; Transcriptional profiling

Indexed keywords

BACTENECIN; ESTROGEN; GLYCOPROTEIN; INTERFERON; LACTOFERRIN; LIPOCORTIN; MULTIDRUG RESISTANCE PROTEIN; MYC PROTEIN; ONCOPROTEIN; SPERMIDINE SYNTHASE; STEFIN; TRANSCRIPTION FACTOR;

ARTICLE; B CELL LEUKEMIA; CARCINOGENESIS; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GRANULOCYTE; HOMEOBOX; HUMAN; HUMAN CELL; MONOCYTE; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; STEM CELL; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE; UPREGULATION;

BIOLOGICAL MARKERS; BLOTTING, NORTHERN; CELL DIFFERENTIATION; CELL LINE; ESTROGENS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTES; HOMEODOMAIN PROTEINS; HUMANS; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS, FUSION; RNA, MESSENGER; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 0037986554     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819031000090273     Document Type: Article

References (43)

1. Kamps, M.P., Murre, C., Sun, X.H. and Baltimore, D. (1990) "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL", Cell 60, 547-555.
2. Dedera, D.A., Waller, E.K., LeBrun, D.P., Sen-Majumdar, A., Stevens, M.E., Barsh, G.S. and Cleary, M.L. (1993) "Chimeric homeobox gene E2A - PBX1 induces proliferation, apoptosis and malignant lymphomas in transgenic mice [published erratum appears in Cell 1993 Nov 19;75(4):826]", Cell 75, 833-843.
3. Kamps, M.P. (1997) "E2A-Pbx1 induces growth, blocks differentiation and interacts with other homeodomain proteins regulating normal differentiation", Curr. Top Microbiol. Immunol. 220, 25-43.
4. Lu, Q., Knoepfler, P.S., Scheele, J., Wright, D.D. and Kamps, M.P. (1995) "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCA-ATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes", Mol. Cell Biol. 15, 3786-3795.
5. Knoepfler, P.S., Calvo, K.R., Chen, H., Antonarakis, S.E. and Kamps, M.P. (1997) "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a - Pbx1", Proc. Natl Acad. Sci. USA 94, 14553-14558.
6. Mann, R.S. and Affloter, M. (1998) "Hox proteins meet more partners", Curr. Opin. Genet Dev. 8, 423-429.
7. Calvo, K.R., Knoepfler, P., McGrath, S. and Kamps, M.P. (1999) "An inhibitory switch depressed by pbx, hox and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a - pbx1 and is dispensable for myeloid immortalization by E2a - pbx1 [In Process Citation]", Oncogene 18, 8033-8043.
8. Kamps, M.P., Look, A.T. and Baltimore, D. (1991) "The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A - Pbx1 fusion proteins with differing transforming potentials", Genes Dev. 5, 358-368.
9. Kamps, M.P. and Wright, D.D. (1994) "Oncoprotein E2A - Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence", Oncogene 9, 3159-3166.
10. Sykes, D.B. and Kamps, M.P. (2001) "Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins", Blood 98, 2308-2318.
11. Diatchenko, L., Lukyanov, S., Lau, Y.F. and Siebert, P.D. (1999) "Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes", Methods Enzymol. 303, 349-380.
12. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R.A., Pestonjamasp, V., Piraino, J., Huttner, K. and Gallo, R.L. (2001) "Innate antimicrobial peptide protects the skin from invasive bacterial infection", Nature 414, 454-457.
13. Friedrich, C.L., Moyles, D., Beveridge, T.J. and Hancock, R.E. (2000) "Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria", Antimicrob. Agents Chemother. 44, 2086-2092.
14. Kos, J. and Lah, T.T. (1998) "Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)", Oncol. Rep. 5, 1349-1361.
15. Owhashi, M., Arita, H. and Hayai, N. (2000) "Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein", J. Biol. Chem. 275, 1279-1286.
16. Stroneck, D. (2002) "Neutrophil alloantigens", Transfus. Med. Rev. 16, 67-75.
17. Kerkhoff, C., Eue, I. and Sorg, C. (1999) "The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes", Pathobiology 67, 230-232.
18. Perretti, M. (1998) "Lipocortin 1 and chemokine modulation of granulocyte and monocyte accumulation in experimental inflammation", Gen. Pharmacol. 31, 545-552.
19. Fleming, T.J., Fleming, M.L. and Malek, T.R. (1993) "Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family", J. Immunol. 151, 2399-2408.
20. Khanna-Gupta, A., Zibello, T. and Berliner, N. (1996) "Coordinate regulation of neutrophil secondary granule protein gene expression", Curr. Top Microbiol. Immunol. 211, 165-171.
21. Iwama, A., Zhang, P., Darlington, G.J., McKercher, S.R., Maki, R. and Tenen, D.G. (1998) "Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha", Nucleic Acids Res. 26, 3034-3043.
22. Bachrach, U., Wang, Y.C. and Tabib, A. (2001) "Polyamines: new cues in cellular signal transduction", News Physiol. Sci. 16, 106-109.
23. Okuwaki, M., Matsumoto, K., Tsujimoto, M. and Nagata, K. (2001) "Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone", FEBS Lett. 506, 272-276.
24. Okuwaki, M., Iwamatsu, A., Tsujimoto, M. and Nagata, K. (2001) "Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor in vitro replication of adenovirus DNA complexed with viral basic core proteins", J. Mol. Biol. 311, 41-55.
25. Okuda, M. (2002) "The role of nucleophosmin in centrosome duplication", Oncogene 21, 6170-6174.
26. Hsu, C.Y. and Yung, B.Y. (1998) "Down-regulation of nucleophosmin/B23 during retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells", Oncogene 16, 915-923.
27. Zeller, K.I., Haggerty, T.J., Barrett, J.F., Guo, Q., Wonsey, D.R. and Dang, C.V. (2001) "Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation", J. Biol. Chem. 276, 48285-48291.
28. Leary, D.J. and Huang, S. (2001) "Regulation of ribosome biogenesis within the nucleolus", FEBS Lett. 509, 145-150.
29. Irevolino, A., Santilli, G., Trotta, R., Guerzoni, C., Cesi, V., Bergamaschi, A., Gambacorti-Passerini, C., Calabretta, B. and Perrotti, D. (2002) "hnRNPA1 necleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis", Mol. Cell Biol. 22, 2255-2266.
30. Hoffman, B., Amanullah, A., Shafarenko, M. and Liebermann, D.A. (2002) "The proto-oncogene c-myc in hematopoietic development and leukemogenesis", Oncogene 21, 3414-3421.
31. Gewirtz, A.M. (2000) "Oligonucleotide therapeutics: a step forward", J. Clin. Oncol. 18, 1809-1811.
32. Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Moroy, T., Bartek, J., Massague, J., Hanel, F. and Eilers, M. (2001) "Repression of p15INK4b expression by Myc through association with Miz-1", Nat. Cell Biol. 3, 392-399.
33. Tao, W., Pennica, D., Xu, L., Kalejta, R.F. and Levine, A.J. (2001) "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1, Genes Dev. 15, 1796-1807.
34. Ikematsu, N., Yoshida, Y., Kawamura-Tsuzuku, J., Ohsugi, M., Onda, M., Hirai, M., Fujimoto, J. and Yamamoto, T. (1999) "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases", Oncogene 18, 7432-7441.
35. Millar, A.L., Pavios, N.J., Xu, J. and Zheng, M.H. (2002) "Rab3D: a regulator of exocytosis in non-neuronal cells", Histol. Histopathol. 17, 929-936.
36. Beites, C.L., Xie, H., Bowser, R. and Trimble, W.S. (1999) "The septin CDCrel-1 binds syntaxin and inhibits exocytosis", Nat. Neurosci. 2, 434-439.
37. Rainer, T.H., Lam, N. and Cocks, R.A. (1999) "Adrenaline upregulates monocyte L-selectin in vitro", Resuscitation 43, 47-55.
38. Drysdale, B.E., Howard, D.L. and Johnson, R.J. (1996) "Identification of a lipopolysaccharide inducible transcription factor in murine macrophages", Mol. Immunol. 33, 989-998.
39. Novak, A. and Dedhar, S. (1999) "Signaling through beta-catenin and Lef/Tcf", Cell Mol. Life Sci. 56, 523-537.
40. Imai, Y., Kurokawa, M., Tanaka, K., Friedman, A.D., Ogawa, S., Mitani, K., Yazaki, Y. and Hirai, H. (1998) "TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation", Biochem. Biophys. Res. Commun. 252, 582-589.
41. Seol, W., Choi, H.S. and Moore, D.D. (1995) "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors", Mol. Endocrinol. 9, 72-85.
42. Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T. and Ozato, K. (2000) "ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages", Immunity 13, 155-165.
43. Dang, J., Inukai, T., Kurosawa, H., Goi, K., Inaba, T., Lenny, N.T., Downing, J.R., Stifani, S. and Look, A.T. (2001) "The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1", Mol. Cell Biol. 21, 5935-5945.